Page last updated: 2024-10-26

dsp 4 and Aging

dsp 4 has been researched along with Aging in 14 studies

DSP 4: RN given refers to parent cpd

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Neuroinflammation is potentiated by early degeneration of the locus coeruleus noradrenergic pathway (LC-NE) commonly seen in aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease."1.46A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. ( Bharani, KL; Derex, R; Granholm, AC; Ledreux, A, 2017)
"The present study was performed to determine if chronic administration of a high salt diet induces hypertension similarly in young and adult rats and if treatment with DSP-4 alters the development of the hypertension."1.28Age-dependent salt-induced hypertension in the rat: prevention with DSP-4, a selective noradrenergic neurotoxin. ( Newman, PS; Soltis, EE, 1991)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's6 (42.86)18.2507
2000's3 (21.43)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bharani, KL1
Derex, R1
Granholm, AC1
Ledreux, A1
Song, S1
Wang, Q1
Jiang, L1
Oyarzabal, E1
Riddick, NV1
Wilson, B1
Moy, SS1
Shih, YI1
Hong, JS1
Jardanhazi-Kurutz, D1
Kummer, MP1
Terwel, D1
Vogel, K1
Dyrks, T1
Thiele, A1
Heneka, MT1
Ranson, RN1
Gaunt, K1
Santer, RM1
Watson, AH1
Matsukawa, M1
Nakadate, K1
Ishihara, I1
Okado, N1
Nakai, S1
Matsunaga, W1
Isobe, K1
Shirokawa, T1
Ponzio, F1
Hallman, H1
Jonsson, G1
Chen, WJ1
Spear, LP1
Spear, NE1
Sirviö, J4
Lahtinen, H1
Riekkinen, P6
Riekkinen, PJ2
Riekkinen, M2
Valjakka, A2
Jäkälä, P1
Lammintausta, R1
Jolkkonen, J1
Soltis, EE1
Newman, PS1
Jacobson, W1
Wilkinson, M1
Gibson, CJ1

Other Studies

14 other studies available for dsp 4 and Aging

ArticleYear
A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats.
    PloS one, 2017, Volume: 12, Issue:12

    Topics: Aging; Analysis of Variance; Animals; Astrocytes; Benzylamines; Brain-Derived Neurotrophic Factor; C

2017
Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions.
    Brain, behavior, and immunity, 2019, Volume: 81

    Topics: Adrenergic Neurons; Aging; Animals; Benzylamines; Brain; Disease Models, Animal; Dopaminergic Neuron

2019
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
    Neurochemistry international, 2010, Volume: 57, Issue:4

    Topics: Aging; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavior, Animal; Benzylamines; Cogniti

2010
The effects of ageing and of DSP-4 administration on the micturition characteristics of male Wistar rats.
    Brain research, 2003, Oct-24, Volume: 988, Issue:1-2

    Topics: Aging; Animals; Autonomic Fibers, Preganglionic; Benzylamines; Central Nervous System; Circadian Rhy

2003
Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic study.
    Neuroscience, 2003, Volume: 122, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Benzylamines; Cell Count; Drug Interactions; Fenclonine; Male; Mic

2003
Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats.
    Neuroscience research, 2006, Volume: 54, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Benzylamines; Frontal Lobe; Immunohistochemistry; Male

2006
Noradrenaline and dopamine interaction in rat brain during development.
    Medical biology, 1981, Volume: 59, Issue:3

    Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Benzylamines; Brain; Brain Stem; Cerebral Corte

1981
Disruptive influence of norepinephrine depletion on sensory preconditioning, but not first-order conditioning, in preweanling rats.
    Behavioral and neural biology, 1993, Volume: 60, Issue:2

    Topics: Adrenergic Agents; Aging; Animals; Animals, Newborn; Association Learning; Benzylamines; Brain; Brai

1993
Spatial learning and noradrenaline content in the brain and periphery of young and aged rats.
    Experimental neurology, 1994, Volume: 125, Issue:2

    Topics: Aging; Animals; Benzylamines; Brain; Learning; Male; Myocardium; Neurotoxins; Norepinephrine; Rats;

1994
DSP-4, a noradrenergic neurotoxin, produces more severe biochemical and functional deficits in aged than young rats.
    Brain research, 1992, Jan-20, Volume: 570, Issue:1-2

    Topics: Aging; Animals; Benzylamines; Brain Chemistry; Choline O-Acetyltransferase; Dopamine; Electroencepha

1992
Effects of alpha 2-drugs and pilocarpine on the high-voltage spindle activity of young and aged control and DSP4-lesioned rats.
    Physiology & behavior, 1991, Volume: 50, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Benzylamines; Brain Mapping; Electroencephalography; E

1991
The effects of noradrenergic neurotoxin, DSP-4, on the performance of young and aged rats in spatial navigation task.
    Brain research, 1991, Nov-01, Volume: 563, Issue:1-2

    Topics: Aging; Animals; Benzylamines; Brain Chemistry; Cognition; Hippocampus; Learning; Male; Norepinephrin

1991
Age-dependent salt-induced hypertension in the rat: prevention with DSP-4, a selective noradrenergic neurotoxin.
    Clinical and experimental hypertension. Part A, Theory and practice, 1991, Volume: 13, Issue:4

    Topics: Aging; Animals; Benzylamines; Blood Pressure; Diet; Hypertension; Kidney; Male; Neurotoxins; Norepin

1991
Effects of the noradrenergic neurotoxin DSP4 on growth and the gonadal steroid- and PMSG-induced release of LH in the prepubertal female rat.
    Brain research bulletin, 1988, Volume: 20, Issue:5

    Topics: Aging; Animals; Benzylamines; Female; Gonadotropins, Equine; Hypothalamus; Luteinizing Hormone; Nalo

1988