dsp 4 and Aging
dsp 4 has been researched along with Aging in 14 studies
DSP 4: RN given refers to parent cpd
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroinflammation is potentiated by early degeneration of the locus coeruleus noradrenergic pathway (LC-NE) commonly seen in aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease." | 1.46 | A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. ( Bharani, KL; Derex, R; Granholm, AC; Ledreux, A, 2017) |
| "The present study was performed to determine if chronic administration of a high salt diet induces hypertension similarly in young and adult rats and if treatment with DSP-4 alters the development of the hypertension." | 1.28 | Age-dependent salt-induced hypertension in the rat: prevention with DSP-4, a selective noradrenergic neurotoxin. ( Newman, PS; Soltis, EE, 1991) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bharani, KL | 1 |
| Derex, R | 1 |
| Granholm, AC | 1 |
| Ledreux, A | 1 |
| Song, S | 1 |
| Wang, Q | 1 |
| Jiang, L | 1 |
| Oyarzabal, E | 1 |
| Riddick, NV | 1 |
| Wilson, B | 1 |
| Moy, SS | 1 |
| Shih, YI | 1 |
| Hong, JS | 1 |
| Jardanhazi-Kurutz, D | 1 |
| Kummer, MP | 1 |
| Terwel, D | 1 |
| Vogel, K | 1 |
| Dyrks, T | 1 |
| Thiele, A | 1 |
| Heneka, MT | 1 |
| Ranson, RN | 1 |
| Gaunt, K | 1 |
| Santer, RM | 1 |
| Watson, AH | 1 |
| Matsukawa, M | 1 |
| Nakadate, K | 1 |
| Ishihara, I | 1 |
| Okado, N | 1 |
| Nakai, S | 1 |
| Matsunaga, W | 1 |
| Isobe, K | 1 |
| Shirokawa, T | 1 |
| Ponzio, F | 1 |
| Hallman, H | 1 |
| Jonsson, G | 1 |
| Chen, WJ | 1 |
| Spear, LP | 1 |
| Spear, NE | 1 |
| Sirviö, J | 4 |
| Lahtinen, H | 1 |
| Riekkinen, P | 6 |
| Riekkinen, PJ | 2 |
| Riekkinen, M | 2 |
| Valjakka, A | 2 |
| Jäkälä, P | 1 |
| Lammintausta, R | 1 |
| Jolkkonen, J | 1 |
| Soltis, EE | 1 |
| Newman, PS | 1 |
| Jacobson, W | 1 |
| Wilkinson, M | 1 |
| Gibson, CJ | 1 |
Other Studies
14 other studies available for dsp 4 and Aging
| Article | Year |
|---|---|
A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats.
Topics: Aging; Analysis of Variance; Animals; Astrocytes; Benzylamines; Brain-Derived Neurotrophic Factor; C | 2017 |
Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions.
Topics: Adrenergic Neurons; Aging; Animals; Benzylamines; Brain; Disease Models, Animal; Dopaminergic Neuron | 2019 |
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
Topics: Aging; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavior, Animal; Benzylamines; Cogniti | 2010 |
The effects of ageing and of DSP-4 administration on the micturition characteristics of male Wistar rats.
Topics: Aging; Animals; Autonomic Fibers, Preganglionic; Benzylamines; Central Nervous System; Circadian Rhy | 2003 |
Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic study.
Topics: Aging; Animals; Animals, Newborn; Benzylamines; Cell Count; Drug Interactions; Fenclonine; Male; Mic | 2003 |
Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Benzylamines; Frontal Lobe; Immunohistochemistry; Male | 2006 |
Noradrenaline and dopamine interaction in rat brain during development.
Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Benzylamines; Brain; Brain Stem; Cerebral Corte | 1981 |
Disruptive influence of norepinephrine depletion on sensory preconditioning, but not first-order conditioning, in preweanling rats.
Topics: Adrenergic Agents; Aging; Animals; Animals, Newborn; Association Learning; Benzylamines; Brain; Brai | 1993 |
Spatial learning and noradrenaline content in the brain and periphery of young and aged rats.
Topics: Aging; Animals; Benzylamines; Brain; Learning; Male; Myocardium; Neurotoxins; Norepinephrine; Rats; | 1994 |
DSP-4, a noradrenergic neurotoxin, produces more severe biochemical and functional deficits in aged than young rats.
Topics: Aging; Animals; Benzylamines; Brain Chemistry; Choline O-Acetyltransferase; Dopamine; Electroencepha | 1992 |
Effects of alpha 2-drugs and pilocarpine on the high-voltage spindle activity of young and aged control and DSP4-lesioned rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Benzylamines; Brain Mapping; Electroencephalography; E | 1991 |
The effects of noradrenergic neurotoxin, DSP-4, on the performance of young and aged rats in spatial navigation task.
Topics: Aging; Animals; Benzylamines; Brain Chemistry; Cognition; Hippocampus; Learning; Male; Norepinephrin | 1991 |
Age-dependent salt-induced hypertension in the rat: prevention with DSP-4, a selective noradrenergic neurotoxin.
Topics: Aging; Animals; Benzylamines; Blood Pressure; Diet; Hypertension; Kidney; Male; Neurotoxins; Norepin | 1991 |
Effects of the noradrenergic neurotoxin DSP4 on growth and the gonadal steroid- and PMSG-induced release of LH in the prepubertal female rat.
Topics: Aging; Animals; Benzylamines; Female; Gonadotropins, Equine; Hypothalamus; Luteinizing Hormone; Nalo | 1988 |