dsb-120 and Colonic-Neoplasms

dsb-120 has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for dsb-120 and Colonic-Neoplasms

Article	Year
Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy. Bioorganic & medicinal chemistry letters, 2006, Jan-15, Volume: 16, Issue:2 The design, synthesis and evaluation of four novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD) prodrugs (1a,b and 2a,b; ) for potential use in carboxypeptidase G2 (CPG2)-based antibody-directed enzyme prodrug therapy (ADEPT) is reported. Although all four prodrugs were shown to be less cytotoxic than the released parent PBDs 3 and 4, the urea prodrugs 1b and 2b were found to be too unstable for use in ADEPT, whereas carbamates 1a and 2a are both stable in an aqueous environment and are good substrates for CPG2. Topics: Antibodies; Antigens, Neoplasm; Antineoplastic Agents; Benzodiazepines; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; gamma-Glutamyl Hydrolase; Humans; Inhibitory Concentration 50; Molecular Structure; Nitrogen Mustard Compounds; Prodrugs; Pyrroles; Structure-Activity Relationship; Time Factors	2006

Article

Year

Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.

Bioorganic & medicinal chemistry letters, 2006, Jan-15, Volume: 16, Issue:2

The design, synthesis and evaluation of four novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD) prodrugs (1a,b and 2a,b; ) for potential use in carboxypeptidase G2 (CPG2)-based antibody-directed enzyme prodrug therapy (ADEPT) is reported. Although all four prodrugs were shown to be less cytotoxic than the released parent PBDs 3 and 4, the urea prodrugs 1b and 2b were found to be too unstable for use in ADEPT, whereas carbamates 1a and 2a are both stable in an aqueous environment and are good substrates for CPG2.

Topics: Antibodies; Antigens, Neoplasm; Antineoplastic Agents; Benzodiazepines; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Design; Drug Screening Assays, Antitumor; gamma-Glutamyl Hydrolase; Humans; Inhibitory Concentration 50; Molecular Structure; Nitrogen Mustard Compounds; Prodrugs; Pyrroles; Structure-Activity Relationship; Time Factors

2006