drupacine has been researched along with Colonic-Neoplasms* in 2 studies
2 other study(ies) available for drupacine and Colonic-Neoplasms
| Article | Year |
|---|---|
Preparation of Stereo-Divergent Compounds from the Natural Product Drupacine Based on Complexity-to-Diversity Strategy.
The Complexity-to-Diversity (CtD) strategy was applied to synthesize a 23-member compound collection from the natural product drupacine, including 21 novel compounds. An unusual benzo [d] cyclopenta [b] azepin skeleton was constructed by Von Braun reaction to cleave C-N bond of drupacine. Moreover, compound 10 has potential cytotoxicity to human colon cancer cells with low toxicity to the normal human colon mucosal epithelial cell lines. Topics: Biological Products; Cell Line; Colonic Neoplasms; Harringtonines; Humans | 2023 |
[Synthesis and antitumor activity of the derivatives of cephalotaxine and drupacine].
To make full use of cephalotaxus plant resources and search for antitumor agents with higher activities and lower side effects.. The C3 hydroxy groups of the cephlotaxine and drupacine were acylated by taxol side chain and its isomers to give a series of derivatives of cephlotaxine and drupacine.. Six novel alkaloid esters were designed and synthesized. The pharmacological screening results showed that VIIIa, VIIIb, IXa and IXc exhibited significant activities on KB, HCT and Bel in vitro.. Novel alkaloid esters are worthy to be intensively studied. Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Colonic Neoplasms; Harringtonines; Homoharringtonine; Humans; KB Cells; Liver Neoplasms; Tumor Cells, Cultured | 2003 |