droperidol has been researched along with Torsade de Pointes in 27 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP)." | 7.74 | Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ( Ackerman, MJ; Eckerman, KM; Jacob, KA; Marienau, ME; Narr, BJ; Nuttall, GA; Oliver, WC; Pawlaski, EM; Wigersma, SK, 2007) |
| "Scientific studies report that there is no basis to issue a black-box warning for perioperative administration of droperidol for postoperative nausea and vomiting on the basis of the potential of adverse cardiac events (prolongation of the QT interval and/or development of torsades de pointes)." | 4.86 | Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system. ( Barash, PG; Halloran, K, 2010) |
| "Current evidence suggests that droperidol is a safe and effective medication for treating nausea and vomiting, headache, vertigo, and agitation in the ED setting." | 4.12 | Emergency medicine updates: Droperidol. ( Cisewski, D; Gottlieb, M; Long, B, 2022) |
| "The Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes." | 3.79 | Does low-dose droperidol increase the risk of polymorphic ventricular tachycardia or death in the surgical patient? ( Ackerman, MJ; Malone, AM; Marienau, ME; Michels, CA; Nuttall, GA; Oliver, WC; Renk, TD; Trudell, LC, 2013) |
| "The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP)." | 3.74 | Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ( Ackerman, MJ; Eckerman, KM; Jacob, KA; Marienau, ME; Narr, BJ; Nuttall, GA; Oliver, WC; Pawlaski, EM; Wigersma, SK, 2007) |
| "Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization." | 2.80 | Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study. ( Owczuk, R; Tracz, K, 2015) |
| "Droperidol is a butyrophenone commonly used as an antiemetic and antipsychotic in the United States since US Food and Drug Administration (FDA) approval in 1970." | 2.42 | Droperidol, QT prolongation, and sudden death: what is the evidence? ( Evers, SJ; Kao, LW; Kirk, MA; Rosenfeld, SH, 2003) |
| "Droperidol is an antipsychotic and antiemetic drug that has been used extensively by emergency physicians, psychiatrists, and anesthesiologists worldwide since 1967." | 2.42 | Droperidol in the emergency department: is it safe? ( Richards, JR; Schneir, AB, 2003) |
| "Torsades de pointes have been observed during treatment with droperidol, a butyrophenone neuroleptic agent." | 1.30 | Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current. ( Deschênes, D; Drolet, B; January, CT; Nadeau, S; Rail, J; Turgeon, J; Zhang, S; Zhou, Z, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 16 (59.26) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, J | 1 |
| Obejero-Paz, CA | 1 |
| Myatt, G | 1 |
| Kuryshev, YA | 1 |
| Bruening-Wright, A | 1 |
| Verducci, JS | 1 |
| Brown, AM | 1 |
| Cisewski, D | 1 |
| Long, B | 1 |
| Gottlieb, M | 1 |
| Cole, JB | 1 |
| Lee, SC | 1 |
| Martel, ML | 2 |
| Smith, SW | 1 |
| Biros, MH | 1 |
| Miner, JR | 1 |
| Sosis, MB | 2 |
| Nuttall, GA | 3 |
| Tracz, K | 1 |
| Owczuk, R | 1 |
| Halloran, K | 1 |
| Barash, PG | 1 |
| Mehta, D | 1 |
| Sanatani, S | 1 |
| Whyte, SD | 1 |
| Malone, AM | 1 |
| Michels, CA | 1 |
| Trudell, LC | 1 |
| Renk, TD | 1 |
| Marienau, ME | 2 |
| Oliver, WC | 2 |
| Ackerman, MJ | 2 |
| Abourjaily, HM | 1 |
| Rosenberg, M | 1 |
| Kao, LW | 1 |
| Kirk, MA | 1 |
| Evers, SJ | 1 |
| Rosenfeld, SH | 1 |
| Richards, JR | 1 |
| Schneir, AB | 1 |
| Orr, EJ | 1 |
| Habib, AS | 2 |
| Gan, TJ | 2 |
| Shale, JH | 1 |
| Shale, CM | 1 |
| Mastin, WD | 1 |
| Martinez, JB | 1 |
| Moos, DD | 1 |
| Dahlen, LL | 1 |
| Charbit, B | 1 |
| Funck-Brentano, C | 1 |
| Eckerman, KM | 1 |
| Jacob, KA | 1 |
| Pawlaski, EM | 1 |
| Wigersma, SK | 1 |
| Narr, BJ | 1 |
| Ludwin, DB | 1 |
| Shafer, SL | 1 |
| Rappaport, BA | 1 |
| Drolet, B | 1 |
| Zhang, S | 1 |
| Deschênes, D | 1 |
| Rail, J | 1 |
| Nadeau, S | 1 |
| Zhou, Z | 1 |
| January, CT | 1 |
| Turgeon, J | 1 |
| SoRelle, R | 1 |
| Horowitz, BZ | 1 |
| Bizovi, K | 1 |
| Moreno, R | 1 |
| Guy, JM | 1 |
| André-Fouet, X | 1 |
| Porte, J | 1 |
| Bertrand, M | 1 |
| Lamaud, M | 1 |
| Verneyre, H | 1 |
5 reviews available for droperidol and Torsade de Pointes
| Article | Year |
|---|---|
Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Arrhythmias, Cardiac; Consumer Product Safety; | 2010 |
Droperidol, QT prolongation, and sudden death: what is the evidence?
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Antipsychotic Agents; Causality; Death, Sudden | 2003 |
Droperidol in the emergency department: is it safe?
Topics: Antiemetics; Antipsychotic Agents; Death, Sudden, Cardiac; Droperidol; Drug Labeling; Emergency Trea | 2003 |
Safety of droperidol in behavioural emergencies.
Topics: Adjuvants, Anesthesia; Antipsychotic Agents; Droperidol; Drug Labeling; Emergency Services, Psychiat | 2004 |
Droperidol's effect on QT interval.
Topics: Adjuvants, Anesthesia; Adverse Drug Reaction Reporting Systems; Antiemetics; Contraindications; Drop | 2006 |
2 trials available for droperidol and Torsade de Pointes
| Article | Year |
|---|---|
Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.
Topics: Adolescent; Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Droperidol; E | 2015 |
The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Topics: Ambulatory Surgical Procedures; Antiemetics; Child, Preschool; Droperidol; Electrocardiography; Fema | 2010 |
20 other studies available for droperidol and Torsade de Pointes
| Article | Year |
|---|---|
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp T | 2013 |
Emergency medicine updates: Droperidol.
Topics: Droperidol; Emergency Medicine; Headache; Humans; Long QT Syndrome; Nausea; Torsades de Pointes; Uni | 2022 |
The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department.
Topics: Adult; Critical Illness; Droperidol; Electrocardiography; Emergency Service, Hospital; Female; Human | 2020 |
A plea for the cautious use of droperidol.
Topics: Antiemetics; Droperidol; Female; Humans; Male; Surgical Procedures, Operative; Tachycardia, Ventricu | 2013 |
In reply.
Topics: Antiemetics; Droperidol; Female; Humans; Male; Surgical Procedures, Operative; Tachycardia, Ventricu | 2013 |
Does low-dose droperidol increase the risk of polymorphic ventricular tachycardia or death in the surgical patient?
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Databases, Factual; Droperidol; Electrocardiography; Fe | 2013 |
The black box warning.
Topics: Adjuvants, Anesthesia; Adverse Drug Reaction Reporting Systems; Antiemetics; Droperidol; Drug Labeli | 2002 |
Vestibular neuritis.
Topics: Droperidol; Drug Labeling; Humans; Long QT Syndrome; Torsades de Pointes; Vestibular Neuronitis | 2003 |
Safety of patients reason for FDA black box warning on droperidol.
Topics: Antiemetics; Arrhythmias, Cardiac; Droperidol; Torsades de Pointes; United States; United States Foo | 2004 |
Ziprasidone for sedation of the agitated ED patient.
Topics: Antipsychotic Agents; Droperidol; Drug Labeling; Emergency Treatment; Humans; Long QT Syndrome; Pipe | 2004 |
Droperidol-induced proarrhythmia: the beginning of an answer?
Topics: Adjuvants, Anesthesia; Droperidol; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Potas | 2007 |
Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?
Topics: Adjuvants, Anesthesia; Anesthesia, General; Antiemetics; Droperidol; Electrocardiography; Long QT Sy | 2007 |
Pro: The Food and Drug Administration Black box warning on droperidol is not justified.
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
Con: The black box warning on droperidol should not be removed (but should be clarified!).
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
FDA response to droperidol black box warning editorials.
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
The black box warning for droperidol.
Topics: Antiemetics; Droperidol; Humans; Long QT Syndrome; Nerve Block; Torsades de Pointes | 2008 |
Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine Antagonists; Droperidol; Electrocardiog | 1999 |
Warnings strengthened on tranquilizer inapsine (Droperidol).
Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Droperidol; Humans; Long QT Syndrome; Produc | 2001 |
Droperidol--behind the black box warning.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Dose-Response Relationship, Drug; Droperidol; | 2002 |
[Torsades de pointes and prolongation of the duration of QT interval after injection of droperidol].
Topics: Adult; Aged; Aged, 80 and over; Droperidol; Electrocardiography; Female; Humans; Long QT Syndrome; M | 1991 |