droperidol has been researched along with Pain in 37 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0." | 9.05 | Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981) |
| "In patients with gastroparesis presenting to the ED, droperidol reduced opioid use, improved pain control, and decreased antiemetic use without any differences in MME per dose, length of stay, hospital admission rate, or cost." | 8.84 | Droperidol undermining gastroparesis symptoms (DRUGS) in the emergency department. ( Arthur, J; Jones, G; Lewis, Z; Stirrup, N, 2024) |
| "Droperidol causes the blockage of the dopamine receptors in the central nervous system that are involved in pain transmission." | 7.74 | Morphine dependence changes the role of droperidol on pain-related electric activities in caudate nucleus. ( Jiao, R; Jin, H; Lv, Y; Xu, M; Xu, X; Yang, C; Yang, H; Zhang, Y, 2008) |
| " All patients were on simple continuous pump dosing during the study." | 5.38 | Long-term use of intrathecal droperidol as an excellent antiemetic in nonmalignant pain--a retrospective study. ( Ahmad-Sabry, MH; Shareghi, G, 2012) |
| "The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 5.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
| "Ondansetron reduced the incidence of postoperative emesis from 62% to 27% (relative risk 0." | 5.07 | Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. ( Furst, SR; Rodarte, A, 1994) |
| "Droperidol is an effective and safe option for the treatment of acute agitation, migraine, nausea, and pain for patients in the ED setting." | 5.05 | Reintegrating droperidol into emergency medicine practice. ( Brown, CS; Cabrera, D; Friend, K; Mattson, A, 2020) |
| "To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0." | 5.05 | Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981) |
| "In patients with gastroparesis presenting to the ED, droperidol reduced opioid use, improved pain control, and decreased antiemetic use without any differences in MME per dose, length of stay, hospital admission rate, or cost." | 4.84 | Droperidol undermining gastroparesis symptoms (DRUGS) in the emergency department. ( Arthur, J; Jones, G; Lewis, Z; Stirrup, N, 2024) |
| " Indications for droperidol included agitation, 68 (86%); nausea/vomiting, 7 (9%); headache, 2 (3%); and other pain, 2 (3%)." | 3.76 | Droperidol use in pediatric emergency department patients. ( Sacchetti, A; Szwak, K, 2010) |
| "Droperidol causes the blockage of the dopamine receptors in the central nervous system that are involved in pain transmission." | 3.74 | Morphine dependence changes the role of droperidol on pain-related electric activities in caudate nucleus. ( Jiao, R; Jin, H; Lv, Y; Xu, M; Xu, X; Yang, C; Yang, H; Zhang, Y, 2008) |
| "On the basis of an examination of 412 patients with myocardial infarction the efficacy of a long-term employment (for 3--4 days) of a neuroleptic Droperidol and a vasodilator Curantyl was examined." | 3.65 | [Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct]. ( Aleksandrova, LA; Avdiushko, BR; Gvatua, NA; Kravtsov, VL; Strokach, NT, 1976) |
| "Droperidol is an effective sedative, anxiolytic, analgesic, and antiemetic medication." | 3.01 | Droperidol Use in the Emergency Department: A Clinical Review. ( Marcolini, EG; Motov, SM; Siegel, RB, 2023) |
| "Morphine was started i." | 2.69 | Comparison of fentanyl and droperidol mixture (neuroleptanalgesia II) with morphine on clinical outcomes in unstable angina patients. ( Bronisz, M; Burduk, P; Guzik, P; Jazdon, M; Jordan, MR; Piechocka, M; Rozek, A, 2000) |
| "Droperidol has myriad pharmacologic properties that may explain its efficacy as an analgesic, including: dopamine D2 antagonist, dose-dependent GABA agonist/antagonist, α2 adrenoreceptor agonist, serotonin antagonist, histamine antagonist, muscarinic and nicotinic cholinergic antagonist, anticholinesterase activity, sodium channel blockade similar to lidocaine, and μ opiate receptor potentiation." | 2.47 | Droperidol analgesia for opioid-tolerant patients. ( Derlet, RW; Ozery, G; Richards, IN; Richards, JR, 2011) |
| "Droperidol is a dopamine receptor antagonist that functions as an analgesic, sedative, and antiemetic." | 1.56 | Effectiveness and safety of droperidol in a United States emergency department. ( Bellolio, F; Cabrera, D; Gaw, CM; Jeffery, MM; Lohse, CM; Mattson, AE, 2020) |
| "Olanzapine is an atypical antipsychotic with similar pharmacologic properties to droperidol." | 1.43 | A Large Retrospective Cohort of Patients Receiving Intravenous Olanzapine in the Emergency Department. ( Cole, JB; Klein, LR; Martel, ML; Rivard, RL, 2016) |
| " All patients were on simple continuous pump dosing during the study." | 1.38 | Long-term use of intrathecal droperidol as an excellent antiemetic in nonmalignant pain--a retrospective study. ( Ahmad-Sabry, MH; Shareghi, G, 2012) |
| "There was no difference in the treatments used or pain relief achieved between migraine, migrainous, and tension-type headaches." | 1.35 | Pain treatment and relief among patients with primary headache subtypes in the ED. ( Miner, J; Trainor, A, 2008) |
| " Dose-response curves were also obtained with tramadol combined with ondansetron or droperidol at 1:1 fixed ratios." | 1.33 | Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice. ( Dürsteler, C; Fernandez, V; Mases, A; Pol, O; Puig, MM, 2006) |
| "Droperidol has both anti-emetic and neuroleptic properties and its epidural administration has been reported (Naji et al." | 1.28 | Akathisia after long-term epidural use of droperidol: a case report. ( Athanassiadis, C; Karamanis, A, 1992) |
| "However in the acute postoperative pain group other factors such as depletion of endorphins by drugs used for anesthesia or due to surgical stress cannot be excluded." | 1.26 | [Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients]. ( Laorden, ML; Miralles, F; Olaso, MJ; Puig, MM, 1982) |
| "The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 1.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (51.35) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 5 (13.51) | 29.6817 |
| 2010's | 6 (16.22) | 24.3611 |
| 2020's | 4 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Siegel, RB | 1 |
| Motov, SM | 1 |
| Marcolini, EG | 1 |
| Stirrup, N | 1 |
| Jones, G | 1 |
| Arthur, J | 1 |
| Lewis, Z | 1 |
| Gaw, CM | 1 |
| Cabrera, D | 2 |
| Bellolio, F | 1 |
| Mattson, AE | 1 |
| Lohse, CM | 1 |
| Jeffery, MM | 1 |
| Mattson, A | 1 |
| Friend, K | 1 |
| Brown, CS | 1 |
| Ahmad-Sabry, MH | 1 |
| Shareghi, G | 1 |
| Stepanova, LG | 1 |
| Tomova, TA | 1 |
| Prosekina, EIu | 1 |
| Martel, ML | 1 |
| Klein, LR | 1 |
| Rivard, RL | 1 |
| Cole, JB | 1 |
| Trainor, A | 1 |
| Miner, J | 1 |
| Gao, HR | 1 |
| Shi, TF | 1 |
| Yang, CX | 1 |
| Zhang, D | 1 |
| Zhang, GW | 1 |
| Zhang, Y | 3 |
| Jiao, RS | 1 |
| Zhang, H | 1 |
| Xu, MY | 2 |
| Szwak, K | 1 |
| Sacchetti, A | 1 |
| Richards, JR | 1 |
| Richards, IN | 1 |
| Ozery, G | 1 |
| Derlet, RW | 1 |
| Dürsteler, C | 1 |
| Mases, A | 1 |
| Fernandez, V | 1 |
| Pol, O | 1 |
| Puig, MM | 2 |
| Su, J | 1 |
| Yang, C | 1 |
| Xu, X | 1 |
| Jiao, R | 1 |
| Jin, H | 1 |
| Lv, Y | 1 |
| Yang, H | 1 |
| Xu, M | 1 |
| Böhlke, R | 1 |
| Marzotko, M | 1 |
| Helmers, JH | 1 |
| Adam, AA | 1 |
| Giezen, J | 1 |
| Laorden, ML | 1 |
| Miralles, F | 1 |
| Olaso, MJ | 1 |
| Muriel Villoria, C | 1 |
| Bueso Sánchez, J | 1 |
| Andrés Grande, MA | 1 |
| Fernández Fraile, R | 1 |
| Tham, EJ | 1 |
| Morris, S | 1 |
| Wright, EM | 1 |
| Campbell, IA | 1 |
| Mapleson, WW | 1 |
| Furst, SR | 1 |
| Rodarte, A | 1 |
| Burduk, P | 1 |
| Guzik, P | 1 |
| Piechocka, M | 1 |
| Bronisz, M | 1 |
| Rozek, A | 1 |
| Jazdon, M | 1 |
| Jordan, MR | 1 |
| Korzh, OB | 2 |
| Timchuk, ID | 1 |
| Gvatua, NA | 1 |
| Avdiushko, BR | 1 |
| Aleksandrova, LA | 1 |
| Strokach, NT | 1 |
| Kravtsov, VL | 1 |
| Hanzlik, J | 1 |
| Sodolski, W | 1 |
| Athanassiadis, C | 1 |
| Karamanis, A | 1 |
| Xing, JQ | 1 |
| Xia, MJ | 1 |
| Wang, T | 1 |
| Mu, JA | 2 |
| Melnick, B | 1 |
| Sawyer, R | 1 |
| Karambelkar, D | 1 |
| Phitayakorn, P | 1 |
| Uy, NT | 1 |
| Patel, R | 1 |
| Qiu, NY | 1 |
| Zhang, JX | 1 |
| Liu, HY | 1 |
| Chen, CQ | 1 |
| Bach, V | 1 |
| Carl, P | 1 |
| Ravlo, O | 1 |
| Crawford, ME | 1 |
| Werner, M | 1 |
| Starec, M | 1 |
| Waitzová, D | 1 |
| Elis, J | 1 |
| Wixson, SK | 1 |
| White, WJ | 1 |
| Hughes, HC | 1 |
| Marshall, WK | 1 |
| Lang, CM | 1 |
| Coghill, JC | 1 |
| Gauntlett, I | 1 |
| Zminkowska, U | 1 |
| Woyda, J | 1 |
| Dyduszynski, A | 1 |
| Burov, IuV | 1 |
| Speranskaia, NP | 1 |
5 reviews available for droperidol and Pain
| Article | Year |
|---|---|
Droperidol Use in the Emergency Department: A Clinical Review.
Topics: Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Antiemetics; Droperidol; Emergency Service, Hos | 2023 |
Reintegrating droperidol into emergency medicine practice.
Topics: Dose-Response Relationship, Drug; Droperidol; Drug Labeling; Drug Monitoring; Drug Utilization; Emer | 2020 |
Droperidol analgesia for opioid-tolerant patients.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Droperidol; Drug Tolerance; Humans; Pain | 2011 |
[Cardiogenic shock: clinical manifestations and treatment].
Topics: Blood Gas Analysis; Dextrans; Dopamine; Droperidol; Fentanyl; Hemodynamics; Humans; Isoproterenol; P | 1975 |
[Management of cardiogenic shock].
Topics: Bradycardia; Dextrans; Digitalis Glycosides; Droperidol; Electric Countershock; Electroconvulsive Th | 1973 |
4 trials available for droperidol and Pain
| Article | Year |
|---|---|
Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl.
Topics: Adolescent; Adult; Aged; Anesthesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Droper | 1981 |
An assessment of prilocaine as a topical anaesthetic agent for fibreoptic bronchoscopy in comparison with lidocaine.
Topics: Adult; Aged; Anesthetics; Anesthetics, Local; Bronchoscopy; Conscious Sedation; Double-Blind Method; | 1994 |
Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy.
Topics: Acetaminophen; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Female; Humans | 1994 |
Comparison of fentanyl and droperidol mixture (neuroleptanalgesia II) with morphine on clinical outcomes in unstable angina patients.
Topics: Analgesics, Opioid; Angina, Unstable; Chromatography, Gas; Dopamine Antagonists; Droperidol; Drug Th | 2000 |
28 other studies available for droperidol and Pain
| Article | Year |
|---|---|
Droperidol undermining gastroparesis symptoms (DRUGS) in the emergency department.
Topics: Analgesics, Opioid; Antiemetics; Droperidol; Emergency Service, Hospital; Gastroparesis; Humans; Len | 2024 |
Effectiveness and safety of droperidol in a United States emergency department.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Analgesics, Opioid; Antiemetics; Arrhythmias, Cardiac; Dro | 2020 |
Long-term use of intrathecal droperidol as an excellent antiemetic in nonmalignant pain--a retrospective study.
Topics: Aged; Analgesics, Opioid; Antiemetics; Droperidol; Female; Humans; Injections, Spinal; Male; Middle | 2012 |
[Treatment of surgical stress response by neuroleptics, leu-enkephalin, glycyl-proline dipeptide, and electroanesthesia in experimental animals].
Topics: Acepromazine; Animals; Antipsychotic Agents; Chlorpromazine; Dipeptides; Dogs; Droperidol; Enkephali | 2014 |
A Large Retrospective Cohort of Patients Receiving Intravenous Olanzapine in the Emergency Department.
Topics: Administration, Intravenous; Adult; Antipsychotic Agents; Benzodiazepines; Droperidol; Drug Therapy, | 2016 |
Pain treatment and relief among patients with primary headache subtypes in the ED.
Topics: Adolescent; Adult; Aged; Droperidol; Emergency Service, Hospital; Headache; Humans; Middle Aged; Pai | 2008 |
The effect of dopamine on pain-related neurons in the parafascicular nucleus of rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Dopamine Antagonists; Droperidol; Elec | 2010 |
Droperidol use in pediatric emergency department patients.
Topics: Adjuvants, Anesthesia; Adolescent; Anti-Anxiety Agents; Antiemetics; Central Nervous System Depressa | 2010 |
Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Antiemetics; Disease Models, Animal; Dose-Response Relationship, Drug; | 2006 |
Differential effects of dopamine on pain-related electric activities in normal rats and morphinistic rats.
Topics: Action Potentials; Analysis of Variance; Animals; Caudate Nucleus; Disease Models, Animal; Dopamine; | 2007 |
Morphine dependence changes the role of droperidol on pain-related electric activities in caudate nucleus.
Topics: Animals; Caudate Nucleus; Dopamine Antagonists; Droperidol; Electrophysiology; Evoked Potentials; Fe | 2008 |
[Combined use of droperidol and xylocitin in peripheral arteriography].
Topics: Acetrizoic Acid; Angiography; Arterial Occlusive Diseases; Contrast Media; Droperidol; Drug Therapy, | 1984 |
[Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients].
Topics: Adult; Aged; Anesthetics; Animals; Biological Assay; Chronic Disease; Droperidol; Endorphins; Female | 1982 |
[Treatment of postoperative pain by peridural analgesia: haemodynamic study (author's transl)].
Topics: Adult; Anesthesia, Epidural; Droperidol; Fentanyl; Hemodynamics; Humans; Male; Middle Aged; Pain; Po | 1981 |
[Use of phentanyl with droperidol or seduxen in nitrous oxide anesthesia in patients with blood vessel diseases of the lower extremities accompanied by pain syndrome].
Topics: Adult; Anesthesia, Inhalation; Diazepam; Droperidol; Fentanyl; Humans; Middle Aged; Nitrous Oxide; P | 1979 |
[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities].
Topics: Adult; Aged; Anesthesia, Endotracheal; Diazepam; Droperidol; Drug Therapy, Combination; Fentanyl; Hu | 1979 |
[Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Dipyridamole; Drop | 1976 |
Akathisia after long-term epidural use of droperidol: a case report.
Topics: Adenocarcinoma; Aged; Akathisia, Drug-Induced; Analgesia, Epidural; Droperidol; Humans; Lung Neoplas | 1992 |
[Study on the analgesic effect of acupuncture with opioid receptors agonist in induced arthritic rats].
Topics: Acupuncture Analgesia; Acupuncture Therapy; Animals; Arthritis; Arthritis, Experimental; Droperidol; | 1989 |
Delayed side effects of droperidol after ambulatory general anesthesia.
Topics: Adult; Ambulatory Surgical Procedures; Anxiety; Droperidol; Female; Humans; Nausea; Pain; Time Facto | 1989 |
[Influence of analgesics and acupuncture on cAMP content in the plasma of induced arthritic rats].
Topics: Acupuncture Therapy; Animals; Arthritis; Arthritis, Experimental; Cyclic AMP; Droperidol; Electric S | 1988 |
Potentiation of epidural opioids with epidural droperidol. A one year retrospective study.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Droperidol; Drug Synergism; Drug Therapy, Combinat | 1986 |
[Evaluation of the analgesic effect of RG-tannin using the "hot plate" and "tail flick" method in mice].
Topics: Analgesics; Animals; Droperidol; Hot Temperature; Male; Mice; Pain; Sensory Thresholds; Tannins | 1988 |
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male; | 1987 |
Pain on injection with droperidol and prevention of pain with etomidate.
Topics: Droperidol; Etomidate; Humans; Injections; Pain | 1986 |
Pain on injection with droperidol.
Topics: Adult; Droperidol; Female; Humans; Injections, Intravenous; Male; Pain | 1985 |
[Value of neuroleptoanalgesia II in the treatment of pain during myocardial infarct].
Topics: Acute Disease; Adult; Aged; Droperidol; Female; Fentanyl; Humans; Male; Middle Aged; Myocardial Infa | 1974 |
[Effect of psychotropic agents on development of an avoidance reaction in albino rats during painful electric stimulation of another rat].
Topics: Amphetamine; Animals; Antidepressive Agents; Droperidol; Electric Stimulation; Escape Reaction; Fear | 1973 |