Page last updated: 2024-10-26

droperidol and Pain, Postoperative

droperidol has been researched along with Pain, Postoperative in 70 studies

Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.

Pain, Postoperative: Pain during the period after surgery.

Research Excerpts

ExcerptRelevanceReference
"1% bupivacaine to PCEA using buprenorphine and droperidol provides better analgesia on coughing after gynecological surgery."9.11Addition of 0.1% bupivacaine to buprenorphine and droperidol in patient-controlled epidural analgesia improved postoperative pain scores on coughing after gynecological surgery. ( Hirabayashi, Y; Inoue, S; Kawakami, T; Mitsuhata, H; Seo, N; Shimohata, K, 2005)
"Coinduction with clonidine significantly increased the number of PONV-free patients after breast cancer surgery with general anesthesia."9.10Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Muhrbeck, O; Oddby-Muhrbeck, E, 2002)
"To investigate whether continuous epidural droperidol and intravenous (IV) intraoperative droperidol inhibit pruritus and postoperative nausea and vomiting (PONV) during epidural morphine analgesia."9.10Continuous epidural, not intravenous, droperidol inhibits pruritus, nausea, and vomiting during epidural morphine analgesia. ( Akamatsu, T; Kanbara, N; Kishi, Y; Kita, T; Mammoto, T; Nakata, K; Sakai, T; Taniguchi, H, 2002)
"In a randomized, placebo-controlled, double-blind trial, we compared the efficacy of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in women undergoing hysterectomy."9.09Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. ( Boldt, J; Fent, MT; Hüttner, I; Maleck, WH; Piper, SN; Triem, JG, 2001)
"We conducted a dose-ranging study of dexamethasone for preventing nausea and vomiting within the first 24 h after the administration of epidural morphine."9.09Dexamethasone for preventing nausea and vomiting associated with epidural morphine: a dose-ranging study. ( Ger, LP; Ho, ST; Liaw, WJ; Liu, HS; Tzeng, JI; Wang, JJ, 2001)
"For 120 young patients who had undergone reconstruction of anterior cruciate ligament of the knee, we investigated the effect of epidural administration of buprenorphine on the incidence of nausea or vomiting, and the anti-emetic effect of epidural administration of droperidol."9.08[Epidural buprenorphine and epidural droperidol for post-operative nausea or vomiting]. ( Takahashi, H; Tanaka, K; Toyoshima, M; Yokoyama, K, 1997)
"Opioid-related side effects, including nausea and vomiting, are common in patients using morphine in patient-controlled analgesia for postoperative pain relief."9.08Improving patient-controlled analgesia: adding droperidol to morphine sulfate to reduce nausea and vomiting and potentiate analgesia. ( Eisenkraft, JB; Freedman, GM; Kreitzer, JM; Reuben, SS, 1995)
"Emesis rate in the acetaminophen group was 9%, and the fentanyl-droperidol group was 13% (not statistically significant)."9.08Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997)
"A double-blind trial of the effect of droperidol on the incidence of nausea and vomiting in patients using patient-controlled analgesia was carried out in 60 healthy women undergoing abdominal hysterectomy."9.07Addition of droperidol to patient-controlled analgesia: effect on nausea and vomiting. ( Clarke, FL; Harris, RW; Peacock, JE; Smith, P; Williams, OA, 1993)
"The incidence of postoperative nausea and vomiting was 33% for group C, 44% for group O and 41% for group D."6.70The addition of antiemetics to the morphine solution in patient controlled analgesia syringes used by children after an appendicectomy does not reduce the incidence of postoperative nausea and vomiting. ( Dickson, U; Fisher, S; Morton, N; Munro, FJ, 2002)
"Postoperative pain was treated with morphine, codeine and/or acetaminophen."6.68Oral ondansetron decreases vomiting after tonsillectomy in children. ( Baxter, MR; Gould, HM; Hall, LE; Komocar, L; MacNeill, HB; Roberts, DJ; Splinter, WM, 1995)
"Ondansetron is a serotonin (5HT) receptor antagonist at both peripheral and central 5-HT3 receptor sites with no known action on dopamine-mediated activity."6.68Droperidol/ondansetron combination controls nausea and vomiting after tubal banding. ( Hamilton, DL; McKenzie, R; Riley, TJ; Uy, NT, 1996)
"Epidural continuous droperidol is effective for reducing pruritus, and single epidural droperidol injection is effective for reducing pruritus and postoperative nausea and vomiting induced by postoperative continuous epidural fentanyl analgesia."5.12Antipruritic and antiemetic effect of epidural droperidol: comparative study between single and continuous epidural injection. ( Lee, IH; Lee, IO, 2006)
"In this study, we compared rates of postoperative nausea and vomiting (PONV) and pruritus after using different protocols for administering epidural droperidol."5.12The antipruritic and antiemetic effects of epidural droperidol: a study of three methods of administration. ( Lee, IH; Lee, IO, 2007)
"Coadministration of 50 mug droperidol and 1 mg morphine on demand via PCA provides a morphine-sparing effect and reduces the frequency of postoperative nausea and vomiting."5.11Morphine sparing with droperidol in patient-controlled analgesia. ( Chia, YY; Ko, NH; Liu, K; Lo, Y, 2005)
"1% bupivacaine to PCEA using buprenorphine and droperidol provides better analgesia on coughing after gynecological surgery."5.11Addition of 0.1% bupivacaine to buprenorphine and droperidol in patient-controlled epidural analgesia improved postoperative pain scores on coughing after gynecological surgery. ( Hirabayashi, Y; Inoue, S; Kawakami, T; Mitsuhata, H; Seo, N; Shimohata, K, 2005)
"Coinduction with clonidine significantly increased the number of PONV-free patients after breast cancer surgery with general anesthesia."5.10Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery. ( Bergendahl, HT; Eksborg, S; Lönnqvist, PA; Muhrbeck, O; Oddby-Muhrbeck, E, 2002)
"To investigate whether continuous epidural droperidol and intravenous (IV) intraoperative droperidol inhibit pruritus and postoperative nausea and vomiting (PONV) during epidural morphine analgesia."5.10Continuous epidural, not intravenous, droperidol inhibits pruritus, nausea, and vomiting during epidural morphine analgesia. ( Akamatsu, T; Kanbara, N; Kishi, Y; Kita, T; Mammoto, T; Nakata, K; Sakai, T; Taniguchi, H, 2002)
"In a randomized, placebo-controlled, double-blind trial, we compared the efficacy of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in women undergoing hysterectomy."5.09Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. ( Boldt, J; Fent, MT; Hüttner, I; Maleck, WH; Piper, SN; Triem, JG, 2001)
"We conducted a dose-ranging study of dexamethasone for preventing nausea and vomiting within the first 24 h after the administration of epidural morphine."5.09Dexamethasone for preventing nausea and vomiting associated with epidural morphine: a dose-ranging study. ( Ger, LP; Ho, ST; Liaw, WJ; Liu, HS; Tzeng, JI; Wang, JJ, 2001)
"Postsurgical analgesia and the incidence of fentanyl-related complications, such as nausea/vomiting, somnolence, pruritus, and respiratory depression, were assessed for 24 hours postoperatively."5.09Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery. ( Ai, K; Kotake, Y; Matsumoto, M; Morisaki, H; Takeda, J, 2000)
"Propofol-fentanyl seems to be a better anesthetic than isoflurane-fentanyl in reducing the incidence of nausea and vomiting after middle ear surgery."5.08Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery. ( Fowles, S; Jellish, WS; Leonetti, JP; Murdoch, JR, 1995)
"Opioid-related side effects, including nausea and vomiting, are common in patients using morphine in patient-controlled analgesia for postoperative pain relief."5.08Improving patient-controlled analgesia: adding droperidol to morphine sulfate to reduce nausea and vomiting and potentiate analgesia. ( Eisenkraft, JB; Freedman, GM; Kreitzer, JM; Reuben, SS, 1995)
"Emesis rate in the acetaminophen group was 9%, and the fentanyl-droperidol group was 13% (not statistically significant)."5.08Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997)
"The addition of droperidol to morphine for patient-controlled analgesia reduces the incidence of nausea and vomiting, but may result in unwanted side effects."5.08Patient-controlled analgesia with morphine and droperidol following caesarean section under spinal anaesthesia. ( Asbury, AJ; Duncan, LA; Frame, WT; Higgins, SP; Millar, K; Russell, D, 1996)
"For 120 young patients who had undergone reconstruction of anterior cruciate ligament of the knee, we investigated the effect of epidural administration of buprenorphine on the incidence of nausea or vomiting, and the anti-emetic effect of epidural administration of droperidol."5.08[Epidural buprenorphine and epidural droperidol for post-operative nausea or vomiting]. ( Takahashi, H; Tanaka, K; Toyoshima, M; Yokoyama, K, 1997)
"05 mg kg(-1) +droperidol 20 microg kg(-1) was given as prophylaxis for postoperative pain and emesis, respectively."5.08Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy. ( Aasbø, V; Buanes, T; Grøgaard, B; Mjåland, O; Raeder, JC, 1998)
"A double-blind trial of the effect of droperidol on the incidence of nausea and vomiting in patients using patient-controlled analgesia was carried out in 60 healthy women undergoing abdominal hysterectomy."5.07Addition of droperidol to patient-controlled analgesia: effect on nausea and vomiting. ( Clarke, FL; Harris, RW; Peacock, JE; Smith, P; Williams, OA, 1993)
" Atropine plus droperidol was superior to atropine plus diazepam or atropine alone in lessening nausea and vomiting and in reducing the need for postoperative analgesia."5.04Double-blind clinical trial of anaesthetic premedication for use in major day surgery. ( Davie, IT; Espley, AJ; Prescott, RJ; Ruckley, CV; Slawson, KB, 1976)
"Postoperative nausea and vomiting (PONV) with morphine therapy develops in more than 60% of patients after surgery, markedly reducing patient QOL."4.81Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review. ( Hirayama, T; Ishii, F; Ogata, H; Yago, K, 2001)
"116 consecutive patients scheduled for breast cancer surgery were prospectively scored according to pain, PONV and sedation after being introduced to a combined evidence-based, empiric multimodal opioid-sparing prevention and treatment regime consisting of Paracetamol, Celecoxib, Dextromethorphan, Gabapetin, Dexamethason and Ondansetron."3.74[Multimodal treatment of pain and nausea in breast cancer surgery]. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2008)
"We report two patients who developed extrapyramidal reactions after epidural droperidol given to prevent postoperative nausea and vomiting."3.70[Extrapyramidal reactions after epidural droperidol]. ( Higa, K; Katori, K; Kohno, S; Matsunaga, M; Yotsui, H, 2000)
"Ketamine has been shown to have a morphine-sparing effect soon after surgery."2.74The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. ( Baud, A; Couvret, C; Favard, L; Fusciardi, J; Laffon, M; Le Tendre, C; Pourrat, X; Remérand, F, 2009)
"Morphine consumption was recorded at the same time points."2.74Intravenous morphine and droperidol after caesarean delivery under subarachnoid anaesthesia has no effect on postoperative pain or analgesic requirements. ( Fassoulaki, A; Melemeni, A; Paraskeva, A; Staikou, C, 2009)
"The complete response (no postoperative nausea and vomiting and no need for rescue antiemetic for a 24-h postoperative period) rates for dexamethasone 8 mg (72."2.71A dose ranging study of dexamethasone for preventing patient-controlled analgesia-related nausea and vomiting: a comparison of droperidol with saline. ( Huang, SJ; Lai, HY; Lee, Y; Lin, PC; Lin, YS; Shyr, MH, 2004)
"The degree of postoperative pain as assessed by postoperative pain scores and the number of supplemental analgesics given, and the frequency of postoperative nausea and vomiting, nightmares, and respiratory depression were compared among the three groups."2.71Preoperative droperidol improved postoperative pain relief in patients undergoing rotator-cuff repair during general anesthesia using intravenous morphine. ( Sakaguchi, M; Satsumae, T; Yamaguchi, H; Yamamoto, S; Yamashita, S, 2003)
"The incidence of postoperative nausea and vomiting was 33% for group C, 44% for group O and 41% for group D."2.70The addition of antiemetics to the morphine solution in patient controlled analgesia syringes used by children after an appendicectomy does not reduce the incidence of postoperative nausea and vomiting. ( Dickson, U; Fisher, S; Morton, N; Munro, FJ, 2002)
"The incidence of postoperative vomiting varied from 4."2.69The antiemetic and dysphoric effects of droperidol in the day surgery patient. ( Lim, BS; Lumsden, G; Pavy, TJ, 1999)
"Postoperative pain was treated with morphine, codeine and/or acetaminophen."2.68Oral ondansetron decreases vomiting after tonsillectomy in children. ( Baxter, MR; Gould, HM; Hall, LE; Komocar, L; MacNeill, HB; Roberts, DJ; Splinter, WM, 1995)
"We investigated the proper dosage of droperidol continuously infused into the epidural space."2.68[Continuous epidural droperidol for postoperative pain]. ( Isosu, T; Katoh, M; Okuaki, A, 1995)
"Propofol, 2 mg/kg, was administered intravenously for induction of anesthesia and followed by propofol, 50 to 250 micrograms/kg/min, for maintenance anesthesia."2.68Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery. ( Fowles, S; Jellish, WS; Leonetti, JP; Murdoch, JR, 1995)
"An intermittent intake of low-dose droperidol with morphine given via a PCA delivery system in two treatment groups gave evidence for a dose-response relation between the amount of droperidol added and the proportion of patients needing a rescue antiemetic."2.68Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia. ( Bach, T; Jackson, D; McKenzie, R; Riley, T; Tantisira, B, 1995)
"Ondansetron is a serotonin (5HT) receptor antagonist at both peripheral and central 5-HT3 receptor sites with no known action on dopamine-mediated activity."2.68Droperidol/ondansetron combination controls nausea and vomiting after tubal banding. ( Hamilton, DL; McKenzie, R; Riley, TJ; Uy, NT, 1996)
"Epidural morphine is effective in the treatment of postoperative pain, but the incidence of associated side effects is high."2.67Epidural droperidol and morphine for postoperative pain. ( Farschtschian, M; Naji, P; Wilder-Smith, CH; Wilder-Smith, OH, 1990)
" This effect is not enhanced by increasing the dosage of droperidol."2.65[Double-blind randomized clinical study of a droperidol-fentanyl combination]. ( Bertrand, AM; Bertrand, JC; Conil, JM; Guerot, A, 1984)
"We evaluated postoperative pain using visual analogue scale (VAS) at rest and on movement, adverse effects such as respiratory and cardiovascular depression, nausea and vomiting for 48 hours after surgery."1.37[Effectiveness of low dose PCEA for postoperative pain after laparoscopic gynecological surgeries--a comparison of laparoscopic ovarian cystectomy and myomectomy]. ( Ikeda, N; Ishikura, H; Miyashita, K; Motegi, R; Ono, T; Sato, M; Sato, Y; Shimohata, K; Shimohata, T, 2011)
"However in the acute postoperative pain group other factors such as depletion of endorphins by drugs used for anesthesia or due to surgical stress cannot be excluded."1.26[Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients]. ( Laorden, ML; Miralles, F; Olaso, MJ; Puig, MM, 1982)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199010 (14.29)18.7374
1990's25 (35.71)18.2507
2000's26 (37.14)29.6817
2010's8 (11.43)24.3611
2020's1 (1.43)2.80

Authors

AuthorsStudies
Tsuboi, S1
Kubota, K1
Mihara, T1
Taguri, M1
Inagawa, G1
Goto, T1
Truesdale, CM1
Soulen, MC1
Clark, TW1
Mondschein, JI1
Wehrenberg-Klee, E1
Malkowicz, SB1
Wein, AJ1
Guzzo, TJ1
Stavropoulos, SW1
Ramirez, L1
Cros, J1
Marin, B1
Boulogne, P1
Bergeron, A1
de Lafont, GE1
Renon-Carron, F1
de Vinzelles, MA1
Guigonis, V1
Nathan, N1
Beaulieu, P1
Kitagawa, N1
Sakurai, M1
Gärtner, R2
Callesen, T2
Kroman, N2
Kehlet, H2
Gall, O1
Adam, F1
Ades, A1
Compère, V1
Abriou, C1
Baert, O1
Fourdrinier, V1
Dureuil, B1
Paraskeva, A1
Staikou, C1
Melemeni, A1
Fassoulaki, A1
Remérand, F1
Le Tendre, C1
Baud, A1
Couvret, C1
Pourrat, X1
Favard, L1
Laffon, M1
Fusciardi, J1
Stuth, EA1
Berens, RJ1
Staudt, SR1
Robertson, FA1
Scott, JP1
Stucke, AG1
Hoffman, GM1
Troshynski, TJ1
Tweddell, JS1
Zuperku, EJ1
Stowman, AM1
Bothun, ED1
Belani, KG1
Shimohata, K2
Shimohata, T1
Ikeda, N1
Sato, Y1
Ono, T1
Motegi, R1
Ishikura, H1
Sato, M1
Miyashita, K1
Mizuno, J1
Morita, S1
Hanaue, N1
Hanaoka, K1
Yokoyama, T1
Ishikawa, Y1
Imashuku, Y1
Kitagawa, H1
Kawamoto, S1
Yuasa, M1
Nosaka, S1
Munro, FJ1
Fisher, S1
Dickson, U1
Morton, N1
Gürses, E1
Sungurtekin, H1
Tomatir, E1
Balci, C1
Gönüllü, M1
Yamamoto, S1
Yamaguchi, H1
Sakaguchi, M1
Yamashita, S1
Satsumae, T1
Liu, GK1
Huang, YG1
Luo, AL1
Zhang, YF1
Ren, HZ1
Lee, Y1
Lai, HY1
Lin, PC1
Lin, YS1
Huang, SJ1
Shyr, MH1
Inoue, S1
Mitsuhata, H1
Kawakami, T1
Hirabayashi, Y1
Seo, N1
Lo, Y1
Chia, YY1
Liu, K1
Ko, NH1
Lee, IH2
Lee, IO2
Boselli, E1
Allaouchiche, B1
Nishikawa, K1
Kimura, S1
Shimodate, Y1
Igarashi, M1
Namiki, A1
Cohen, SE1
Rothblatt, AJ1
Albright, GA1
Bertrand, JC1
Bertrand, AM1
Conil, JM1
Guerot, A1
Frings, N1
von Bormann, B1
Kroh, U1
Lennartz, H1
Tanaka, A1
Laorden, ML1
Miralles, F1
Olaso, MJ1
Puig, MM1
Esperov, BN1
Zimin, AM1
Jellish, WS2
Leonetti, JP2
Murdoch, JR2
Fowles, S2
McKenzie, R2
Tantisira, B1
Jackson, D1
Bach, T1
Riley, T1
Freedman, GM1
Kreitzer, JM1
Reuben, SS1
Eisenkraft, JB1
Roberts, CJ1
Millar, JM1
Goat, VA1
Isosu, T1
Katoh, M1
Okuaki, A1
Splinter, WM1
Baxter, MR1
Gould, HM1
Hall, LE1
MacNeill, HB1
Roberts, DJ1
Komocar, L1
Oikkonen, M1
Heine, H1
Salminen, U1
Romppanen, O1
Inberg, P1
Lewis, IH1
Wilder-Smith, CH2
Wilder-Smith, OH2
Farschtschian, M2
Naji, P2
Williams, OA1
Clarke, FL1
Harris, RW1
Smith, P1
Peacock, JE1
Sharma, SK1
Davies, MW1
Rainov, NG1
Gutjahr, T1
Burkert, W1
Tang, J1
Watcha, MF1
White, PF1
Russell, D1
Duncan, LA1
Frame, WT1
Higgins, SP1
Asbury, AJ1
Millar, K1
Uy, NT1
Riley, TJ1
Hamilton, DL1
Padda, GS1
Cruz, OA1
Krock, JL1
Yokoyama, K1
Takahashi, H1
Toyoshima, M1
Tanaka, K1
Raeder, JC1
Mjåland, O1
Aasbø, V1
Grøgaard, B1
Buanes, T1
Hadji, F1
Eastwood, D1
Fear, S1
Corfield, HJ1
Jokela, R1
Koivuranta, M1
Habre, W1
Wilson, D1
Johnson, CM1
Lim, BS1
Pavy, TJ1
Lumsden, G1
Kotake, Y1
Matsumoto, M1
Ai, K1
Morisaki, H1
Takeda, J1
Yotsui, H1
Matsunaga, M1
Katori, K1
Kohno, S1
Higa, K1
Hirayama, T1
Ishii, F1
Yago, K1
Ogata, H1
Ho, ST1
Wang, JJ1
Tzeng, JI1
Liu, HS1
Ger, LP1
Liaw, WJ1
Silvasti, M1
Pitkänen, M1
Piper, SN1
Triem, JG1
Maleck, WH1
Fent, MT1
Hüttner, I1
Boldt, J1
Nakata, K1
Mammoto, T1
Kita, T1
Taniguchi, H1
Kanbara, N1
Akamatsu, T1
Sakai, T1
Kishi, Y1
Oddby-Muhrbeck, E1
Eksborg, S1
Bergendahl, HT1
Muhrbeck, O1
Lönnqvist, PA1
Prescott, RJ1
Espley, AJ1
Davie, IT1
Slawson, KB1
Ruckley, CV1
Shelestiuk, GS1
Pakhal'chuk, MS1
Borisko, AS1
Carvalho, JC1
Mathias, RS1
Senra, WG1
Torres, ML1
Adam, C1
Vasconcelos, A1
de Moraes, JE1
Corrallo, SR1
Van der Walt, JH1
Nicholls, B1
Bentley, M1
Tomkins, DP1
Ochi, G1
Mastutani, M1
Ishiguro, A1
Hori, S1
Fujii, A1
Sato, T1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients[NCT02160301]Phase 40 participants (Actual)Interventional2017-11-30Withdrawn (stopped due to Insufficient infrastructure/funding for enrollment)
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283]Phase 41,544 participants (Anticipated)Interventional2021-04-12Enrolling by invitation
Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.[NCT01679093]Phase 366 participants (Actual)Interventional2009-06-30Completed
Study of Evaluation of the Profile of Efficiency / Tolerance of 2 Doses of Intravenous Droperidol in the Prevention of the Postoperative Nausea and Vomits Related to the Surgery of the Thyroid[NCT00445055]Phase 471 participants (Actual)Interventional2007-04-30Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for droperidol and Pain, Postoperative

ArticleYear
[Patient-controlled analgesia. Pain and Locoregional Anesthesia Committee and the Standards Committee of the French Society of Anesthesia and Intensive Care].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Analgesia, Patient-Controlled; Antiemetics; Droperidol; Drug Administration Routes; Drug Synergism;

2009
[Intravenous patient-controlled analgesia (IV-PCA) for relief of postoperative pain].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60, Issue:8

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Droperidol; Fentanyl; Humans; Infusi

2011
Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review.
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2001, Volume: 121, Issue:2

    Topics: Antiemetics; Dexamethasone; Droperidol; Humans; Metoclopramide; Morphine; Ondansetron; Pain, Postope

2001

Trials

45 trials available for droperidol and Pain, Postoperative

ArticleYear
Analgesic interaction between ondansetron and acetaminophen after tonsillectomy in children: the Paratron randomized, controlled trial.
    European journal of pain (London, England), 2015, Volume: 19, Issue:5

    Topics: Acetaminophen; Adenoidectomy; Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Analgesics, Opioid; A

2015
Intravenous morphine and droperidol after caesarean delivery under subarachnoid anaesthesia has no effect on postoperative pain or analgesic requirements.
    European journal of anaesthesiology, 2009, Volume: 26, Issue:10

    Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Antiemetics; Cesarean Section; Double-Blind Meth

2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:6

    Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana

2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:6

    Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana

2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:6

    Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana

2009
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:6

    Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana

2009
The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:4

    Topics: Airway Management; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cardiopulmonary Bypass; Chil

2011
The addition of antiemetics to the morphine solution in patient controlled analgesia syringes used by children after an appendicectomy does not reduce the incidence of postoperative nausea and vomiting.
    Paediatric anaesthesia, 2002, Volume: 12, Issue:7

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, General; Antiemetics; Appendectomy; C

2002
The addition of droperidol or clonidine to epidural tramadol shortens onset time and increases duration of postoperative analgesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:2

    Topics: Abdomen; Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Analgesia, Epidural; Analges

2003
Preoperative droperidol improved postoperative pain relief in patients undergoing rotator-cuff repair during general anesthesia using intravenous morphine.
    Journal of clinical anesthesia, 2003, Volume: 15, Issue:7

    Topics: Adjuvants, Anesthesia; Anesthesia, General; Double-Blind Method; Droperidol; Female; Humans; Injecti

2003
[Patient-controlled analgesia with tramadol and tramadol/droperidol mixture after abdominal hysterectomy: a double-blinded, randomized controlled trial].
    Zhonghua yi xue za zhi, 2003, Nov-25, Volume: 83, Issue:22

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Double-Blind Method; Droperidol; Drug Therap

2003
A dose ranging study of dexamethasone for preventing patient-controlled analgesia-related nausea and vomiting: a comparison of droperidol with saline.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:4

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Dexamethasone; Dose-Response R

2004
Addition of 0.1% bupivacaine to buprenorphine and droperidol in patient-controlled epidural analgesia improved postoperative pain scores on coughing after gynecological surgery.
    Journal of clinical anesthesia, 2005, Volume: 17, Issue:3

    Topics: Adult; Analgesia, Epidural; Analgesia, Patient-Controlled; Bupivacaine; Buprenorphine; Central Nervo

2005
Morphine sparing with droperidol in patient-controlled analgesia.
    Journal of clinical anesthesia, 2005, Volume: 17, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Double-Blind Method; Droperidol; Drug Therapy, Combination; Fe

2005
Antipruritic and antiemetic effect of epidural droperidol: comparative study between single and continuous epidural injection.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:3

    Topics: Aged; Anesthesia, Epidural; Antiemetics; Antipruritics; Droperidol; Female; Gastrectomy; Humans; Inj

2006
A comparison of intravenous-based and epidural-based techniques for anesthesia and postoperative analgesia in elderly patients undergoing laparoscopic cholecystectomy.
    Journal of anesthesia, 2007, Volume: 21, Issue:1

    Topics: Adjuvants, Anesthesia; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesi

2007
The antipruritic and antiemetic effects of epidural droperidol: a study of three methods of administration.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:1

    Topics: Aged; Analgesia, Epidural; Antiemetics; Antipruritics; Double-Blind Method; Droperidol; Drug Adminis

2007
[Double-blind randomized clinical study of a droperidol-fentanyl combination].
    Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:3

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Droperidol; Drug Combinations; Fentanyl;

1984
[Peridural anesthesia and analgesia results in general surgery].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1982, Volume: 53, Issue:3

    Topics: Anesthesia, Epidural; Bupivacaine; Droperidol; Drug Combinations; Endocrine Glands; Evaluation Studi

1982
Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:4

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthesia, Intravenous; Anesthetics, Inhalation; An

1995
Antiemetic efficacy of a droperidol-morphine combination in patient-controlled analgesia.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Dose-Response Relationship, Drug; Double-Blind Met

1995
Improving patient-controlled analgesia: adding droperidol to morphine sulfate to reduce nausea and vomiting and potentiate analgesia.
    The Mount Sinai journal of medicine, New York, 1995, Volume: 62, Issue:3

    Topics: Analgesia, Patient-Controlled; Droperidol; Drug Combinations; Drug Synergism; Female; Humans; Male;

1995
The antiemetic effectiveness of droperidol during morphine patient-controlled analgesia.
    Anaesthesia, 1995, Volume: 50, Issue:6

    Topics: Adult; Analgesia, Patient-Controlled; Double-Blind Method; Droperidol; Female; Humans; Laminectomy;

1995
[Continuous epidural droperidol for postoperative pain].
    Masui. The Japanese journal of anesthesiology, 1995, Volume: 44, Issue:7

    Topics: Analgesia, Epidural; Buprenorphine; Droperidol; Drug Administration Schedule; Female; Humans; Pain M

1995
Oral ondansetron decreases vomiting after tonsillectomy in children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:4

    Topics: Administration, Oral; Adolescent; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesth

1995
Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1995, Volume: 112, Issue:2

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Droperidol; Ear,

1995
Dixyrazine premedication for cataract surgery. A comparison with diazepam.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesia; Antipsychotic Agents; Anxiety; Blood Press

1994
Epidural droperidol reduces the side effects and duration of analgesia of epidural sufentanil.
    Anesthesia and analgesia, 1994, Volume: 79, Issue:1

    Topics: Analgesia, Epidural; Double-Blind Method; Droperidol; Drug Combinations; Drug Interactions; Female;

1994
Addition of droperidol to patient-controlled analgesia: effect on nausea and vomiting.
    Anaesthesia, 1993, Volume: 48, Issue:10

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Double-Blind Method; Droperidol; Female; Humans; Hystere

1993
Patient-controlled analgesia with a mixture of morphine and droperidol.
    British journal of anaesthesia, 1993, Volume: 71, Issue:3

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Anesthesia, General; Droperidol; Female; Humans; Hystere

1993
Intra-operative epidural morphine, fentanyl, and droperidol for control of pain after spinal surgery. A prospective, randomized, placebo-controlled, and double-blind trial.
    Acta neurochirurgica, 1996, Volume: 138, Issue:1

    Topics: Analgesia, Epidural; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Drop

1996
A comparison of costs and efficacy of ondansetron and droperidol as prophylactic antiemetic therapy for elective outpatient gynecologic procedures.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:2

    Topics: Activities of Daily Living; Adult; Ambulatory Surgical Procedures; Antiemetics; Anxiety; Conscious S

1996
Patient-controlled analgesia with morphine and droperidol following caesarean section under spinal anaesthesia.
    Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:5

    Topics: Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spinal; Antie

1996
Droperidol/ondansetron combination controls nausea and vomiting after tubal banding.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:6

    Topics: Antiemetics; Dopamine Antagonists; Double-Blind Method; Droperidol; Drug Combinations; Female; Human

1996
Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol.
    Ophthalmology, 1997, Volume: 104, Issue:3

    Topics: Acetaminophen; Administration, Rectal; Analgesia; Analgesics; Anesthesia Recovery Period; Child; Chi

1997
[Epidural buprenorphine and epidural droperidol for post-operative nausea or vomiting].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Anterior Cruciate

1997
Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:1

    Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, D

1998
Tropisetron or droperidol in the prevention of postoperative nausea and vomiting. A comparative, randomised, double-blind study in women undergoing laparoscopic cholecystectomy.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:6

    Topics: Adult; Aged; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Droperidol; Female; Hu

1999
The antiemetic and dysphoric effects of droperidol in the day surgery patient.
    Anaesthesia and intensive care, 1999, Volume: 27, Issue:4

    Topics: Adult; Akathisia, Drug-Induced; Ambulatory Surgical Procedures; Antiemetics; Droperidol; Female; Hum

1999
Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery.
    Journal of clinical anesthesia, 2000, Volume: 12, Issue:1

    Topics: Adjuvants, Anesthesia; Anal Canal; Analgesia, Epidural; Analgesics, Opioid; Analysis of Variance; An

2000
Dexamethasone for preventing nausea and vomiting associated with epidural morphine: a dose-ranging study.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:3

    Topics: Adult; Analgesia, Epidural; Antiemetics; Dexamethasone; Dose-Response Relationship, Drug; Double-Bli

2001
Patient-controlled epidural analgesia versus continuous epidural analgesia after total knee arthroplasty.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:4

    Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesi

2001
Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy.
    European journal of anaesthesiology, 2001, Volume: 18, Issue:4

    Topics: Antiemetics; Blood Loss, Surgical; Droperidol; Female; Humans; Hysterectomy; Indoles; Metoclopramide

2001
Continuous epidural, not intravenous, droperidol inhibits pruritus, nausea, and vomiting during epidural morphine analgesia.
    Journal of clinical anesthesia, 2002, Volume: 14, Issue:2

    Topics: Abdomen; Adolescent; Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Antiemetics; Double-Blind

2002
Effects of clonidine on postoperative nausea and vomiting in breast cancer surgery.
    Anesthesiology, 2002, Volume: 96, Issue:5

    Topics: Adrenergic alpha-Agonists; Aged; Anesthesia, General; Antiemetics; Blood Pressure; Breast Neoplasms;

2002
Double-blind clinical trial of anaesthetic premedication for use in major day surgery.
    Lancet (London, England), 1976, May-29, Volume: 1, Issue:7970

    Topics: Adult; Anesthesia, Inhalation; Atropine; Clinical Trials as Topic; Day Care, Medical; Diazepam; Drop

1976
Epidural droperidol and morphine for postoperative pain.
    Anesthesia and analgesia, 1990, Volume: 70, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Droperidol; Drug Combinations; Drug Synergism;

1990
Oral premedication in children.
    Anaesthesia and intensive care, 1987, Volume: 15, Issue:2

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Droperidol; Humans; Hypnotics and Sedat

1987

Other Studies

22 other studies available for droperidol and Pain, Postoperative

ArticleYear
Predictive factors of postoperative fentanyl consumption in patients with inflammatory bowel disease: a retrospective cohort study.
    BMC anesthesiology, 2022, 03-11, Volume: 22, Issue:1

    Topics: Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Biological Products; Cohort Studies;

2022
Percutaneous computed tomography-guided renal mass radiofrequency ablation versus cryoablation: doses of sedation medication used.
    Journal of vascular and interventional radiology : JVIR, 2013, Volume: 24, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Catheter Ablation; Cryosurgery; Droperidol; Female; Fentanyl; Humans

2013
Drug-induced reverse ocular dipping.
    BMJ case reports, 2014, Sep-29, Volume: 2014

    Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Droperidol; Fentanyl; Humans; Laminectomy; Male; Oc

2014
[Postoperative inconveniences after breast cancer surgery].
    Ugeskrift for laeger, 2008, Jun-02, Volume: 170, Issue:23

    Topics: Acetaminophen; Amines; Analgesics; Antiemetics; Antitussive Agents; Breast Neoplasms; Celecoxib; Cyc

2008
[Multimodal treatment of pain and nausea in breast cancer surgery].
    Ugeskrift for laeger, 2008, Jun-02, Volume: 170, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Antiemetics; Antitussive Agents; Breast Neoplasm

2008
[Recommended use of morphine in children for postoperative pain relief. Pain and Locoregional Anesthesia Committee and the Standards Committee of the French Society of Anesthesia and Intensive Care].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Adolescent; Age Factors; Analgesia, Patient-Controlled; Child; Child, Preschool; Dose-Response Relat

2009
[Acute respiratory distress subordinate to a morphine overdose during a frail elderly patient controlled analgesia].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:4

    Topics: Acute Kidney Injury; Adjuvants, Anesthesia; Aged, 80 and over; Analgesia, Patient-Controlled; Analge

2009
Discomfort, delirium, and PONV in infants and young children undergoing strabismus surgery.
    Minnesota medicine, 2011, Volume: 94, Issue:3

    Topics: Analgesics; Antiemetics; Delirium; Dexamethasone; Droperidol; Hospitals, University; Humans; Minneso

2011
[Effectiveness of low dose PCEA for postoperative pain after laparoscopic gynecological surgeries--a comparison of laparoscopic ovarian cystectomy and myomectomy].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60, Issue:6

    Topics: Adult; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Buprenorphine; Droperidol; Endome

2011
[Evaluation of the side effects of intravenous patient controlled analgesia after spine surgery].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60, Issue:8

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Bradycardia; Droperidol; Female; Humans; Hypotension; In

2011
Morphine sparing with droperidol in patient-controlled analgesia.
    Journal of clinical anesthesia, 2006, Volume: 18, Issue:6

    Topics: Analgesia, Patient-Controlled; Droperidol; Humans; Morphine; Pain, Postoperative

2006
Early respiratory depression with epidural narcotic and intravenous droperidol.
    Anesthesiology, 1983, Volume: 59, Issue:6

    Topics: Adult; Analgesia; Anesthesia, Obstetrical; Apnea; Cesarean Section; Droperidol; Drug Interactions; F

1983
[Experimental and clinical studies on arousal effects of naloxone after droperidol-pentazocine anesthesia (author's transl)].
    Masui. The Japanese journal of anesthesiology, 1982, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aged; Arousal; Consciousness; Droperidol; Drug Synergism; Female; Humans; Male; M

1982
[Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients].
    Revista espanola de fisiologia, 1982, Volume: 38, Issue:3

    Topics: Adult; Aged; Anesthetics; Animals; Biological Assay; Chronic Disease; Droperidol; Endorphins; Female

1982
[Long-term epidural anesthesia in the postoperative period].
    Khirurgiia, 1981, Issue:8

    Topics: Abdomen, Acute; Adolescent; Adult; Anesthesia, Epidural; Diphenhydramine; Droperidol; Female; Humans

1981
Influence of droperidol on nausea and vomiting during patient-controlled analgesia.
    British journal of anaesthesia, 1994, Volume: 73, Issue:4

    Topics: Analgesia, Patient-Controlled; Data Interpretation, Statistical; Droperidol; Female; Humans; Nausea;

1994
The impact of audit in a district general hospital on post-operative nausea and vomiting after major gynaecological surgery.
    European journal of anaesthesiology, 1998, Volume: 15, Issue:5

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia Department, Hospital; Antiemetics; Att

1998
Extrapyramidal side-effects from droperidol mixed with morphine for patient-controlled analgesia in two children.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:4

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Appendectomy; Basal Ganglia Diseases; Benztropine

1999
[Extrapyramidal reactions after epidural droperidol].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:10

    Topics: Adult; Antiemetics; Basal Ganglia Diseases; Droperidol; Drug Interactions; Female; Humans; Injection

2000
[Use of neruoleptoanalgesia in the postoperative period].
    Vestnik khirurgii imeni I. I. Grekova, 1976, Volume: 117, Issue:11

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diphenhydramine; Droperidol; Drug Combinations; Fe

1976
Systemic droperidol and epidural morphine in the management of postoperative pain.
    Anesthesia and analgesia, 1991, Volume: 72, Issue:3

    Topics: Analgesia, Epidural; Droperidol; Drug Interactions; Female; Humans; Morphine; Pain, Postoperative

1991
[Epidural administration of morphine-droperidol mixture for postoperative analgesia].
    Masui. The Japanese journal of anesthesiology, 1985, Volume: 34, Issue:3

    Topics: Anesthesia, Epidural; Antiemetics; Droperidol; Female; Humans; Hypnotics and Sedatives; Male; Middle

1985