droperidol has been researched along with Long QT Syndrome in 47 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP)." | 7.74 | Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ( Ackerman, MJ; Eckerman, KM; Jacob, KA; Marienau, ME; Narr, BJ; Nuttall, GA; Oliver, WC; Pawlaski, EM; Wigersma, SK, 2007) |
| "Droperidol is a highly potent butyrophenone used for the therapy of postoperative nausea and vomiting." | 5.36 | The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome. ( Ehmke, H; Friederich, P; Kebernik, J; Schwoerer, AP, 2010) |
| "When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol." | 5.33 | Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ( Albaladejo, P; Charbit, B; Funck-Brentano, C; Legrand, M; Marty, J; Samain, E, 2005) |
| "Droperidol is an effective and safe option for the treatment of acute agitation, migraine, nausea, and pain for patients in the ED setting." | 5.05 | Reintegrating droperidol into emergency medicine practice. ( Brown, CS; Cabrera, D; Friend, K; Mattson, A, 2020) |
| "Scientific studies report that there is no basis to issue a black-box warning for perioperative administration of droperidol for postoperative nausea and vomiting on the basis of the potential of adverse cardiac events (prolongation of the QT interval and/or development of torsades de pointes)." | 4.86 | Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system. ( Barash, PG; Halloran, K, 2010) |
| " In the patient described in this article, heart block occurred and the Q-Tc interval became prolonged after muscle relaxant reversal with neostigmine; both were considered to be related to the combination of agents used in the case, as well as to other predisposing factors such as morbid obesity." | 4.84 | Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report. ( Shields, JA, 2008) |
| "Current evidence suggests that droperidol is a safe and effective medication for treating nausea and vomiting, headache, vertigo, and agitation in the ED setting." | 4.12 | Emergency medicine updates: Droperidol. ( Cisewski, D; Gottlieb, M; Long, B, 2022) |
| "The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP)." | 3.74 | Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ( Ackerman, MJ; Eckerman, KM; Jacob, KA; Marienau, ME; Narr, BJ; Nuttall, GA; Oliver, WC; Pawlaski, EM; Wigersma, SK, 2007) |
| "The statistically significant prolongation of QTc time after a sedative dose of droperidol is of concern because it may increase the risk for malignant cardiac arrhythmias." | 3.72 | Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. ( Berens, RJ; Cava, JR; Hoffman, GM; Stucke, AG; Stuth, EA, 2004) |
| "Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization." | 2.80 | Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study. ( Owczuk, R; Tracz, K, 2015) |
| "Droperidol is a butyrophenone commonly used as an antiemetic and antipsychotic in the United States since US Food and Drug Administration (FDA) approval in 1970." | 2.42 | Droperidol, QT prolongation, and sudden death: what is the evidence? ( Evers, SJ; Kao, LW; Kirk, MA; Rosenfeld, SH, 2003) |
| "Droperidol is an antipsychotic and antiemetic drug that has been used extensively by emergency physicians, psychiatrists, and anesthesiologists worldwide since 1967." | 2.42 | Droperidol in the emergency department: is it safe? ( Richards, JR; Schneir, AB, 2003) |
| "Droperidol is a highly potent butyrophenone used for the therapy of postoperative nausea and vomiting." | 1.36 | The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome. ( Ehmke, H; Friederich, P; Kebernik, J; Schwoerer, AP, 2010) |
| "When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol." | 1.33 | Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ( Albaladejo, P; Charbit, B; Funck-Brentano, C; Legrand, M; Marty, J; Samain, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 32 (68.09) | 29.6817 |
| 2010's | 9 (19.15) | 24.3611 |
| 2020's | 5 (10.64) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Hernández-Rodríguez, L | 1 |
| Bellolio, F | 1 |
| Cabrera, D | 2 |
| Mattson, AE | 1 |
| VanMeter, D | 1 |
| Grush, AE | 1 |
| Oliveira J E Silva, L | 1 |
| Cisewski, D | 1 |
| Long, B | 1 |
| Gottlieb, M | 1 |
| Cole, JB | 1 |
| Lee, SC | 1 |
| Martel, ML | 2 |
| Smith, SW | 1 |
| Biros, MH | 1 |
| Miner, JR | 1 |
| Mattson, A | 1 |
| Friend, K | 1 |
| Brown, CS | 1 |
| DiSalvo, PC | 1 |
| Backus, TC | 1 |
| Chiang, WK | 1 |
| Patel, J | 1 |
| Scott, JP | 1 |
| Stuth, EA | 2 |
| Stucke, AG | 2 |
| Cava, JR | 2 |
| Berens, RJ | 2 |
| Tracz, K | 1 |
| Owczuk, R | 1 |
| Charbit, B | 3 |
| Alvarez, JC | 1 |
| Dasque, E | 1 |
| Abe, E | 1 |
| Démolis, JL | 1 |
| Funck-Brentano, C | 3 |
| Sneyd, JR | 1 |
| Halloran, K | 1 |
| Barash, PG | 1 |
| Schwoerer, AP | 1 |
| Kebernik, J | 1 |
| Ehmke, H | 1 |
| Friederich, P | 1 |
| Mehta, D | 1 |
| Sanatani, S | 1 |
| Whyte, SD | 1 |
| Schroeter, E | 1 |
| Schmitz, A | 1 |
| Haas, T | 1 |
| Weiss, M | 1 |
| Gerber, AC | 1 |
| Spevak, C | 1 |
| Hamsher, C | 1 |
| Brown, CQ | 1 |
| Wedam, EF | 1 |
| Haigney, MC | 1 |
| Faine, B | 1 |
| Hogrefe, C | 1 |
| Kao, LW | 1 |
| Kirk, MA | 1 |
| Evers, SJ | 1 |
| Rosenfeld, SH | 1 |
| Meyer, RJ | 1 |
| Richards, JR | 1 |
| Schneir, AB | 1 |
| Orr, EJ | 1 |
| Gómez-Arnau, JI | 1 |
| Chang, N | 1 |
| Simone, A | 1 |
| Schultheis, L | 1 |
| Rappaport, B | 1 |
| Young, D | 1 |
| Zhang, Y | 1 |
| Luo, Z | 1 |
| White, PF | 3 |
| Shale, JH | 1 |
| Shale, CM | 1 |
| Mastin, WD | 1 |
| Hoffman, GM | 1 |
| Scuderi, PE | 1 |
| Albaladejo, P | 1 |
| Legrand, M | 1 |
| Samain, E | 1 |
| Marty, J | 1 |
| Song, D | 1 |
| Abrao, J | 2 |
| Klein, KW | 1 |
| Navarette, B | 1 |
| Katz, RI | 1 |
| Sosis, MB | 2 |
| Martinez, JB | 1 |
| Moos, DD | 1 |
| Dahlen, LL | 1 |
| Zbinden, S | 1 |
| Nuttall, GA | 1 |
| Eckerman, KM | 1 |
| Jacob, KA | 1 |
| Pawlaski, EM | 1 |
| Wigersma, SK | 1 |
| Marienau, ME | 1 |
| Oliver, WC | 1 |
| Narr, BJ | 1 |
| Ackerman, MJ | 1 |
| Wyllie, AR | 1 |
| Carvalhana, VV | 1 |
| Burry, LD | 1 |
| Teresi, JE | 1 |
| Shields, JA | 1 |
| Habib, AS | 1 |
| Gan, TJ | 1 |
| Ludwin, DB | 1 |
| Shafer, SL | 1 |
| Rappaport, BA | 1 |
| SoRelle, R | 1 |
| Horowitz, BZ | 1 |
| Bizovi, K | 1 |
| Moreno, R | 1 |
| Guy, JM | 1 |
| André-Fouet, X | 1 |
| Porte, J | 1 |
| Bertrand, M | 1 |
| Lamaud, M | 1 |
| Verneyre, H | 1 |
9 reviews available for droperidol and Long QT Syndrome
| Article | Year |
|---|---|
Reintegrating droperidol into emergency medicine practice.
Topics: Dose-Response Relationship, Drug; Droperidol; Drug Labeling; Drug Monitoring; Drug Utilization; Emer | 2020 |
Droperidol- and ondansetron-induced life-threatening arrhythmias.
Topics: Aged; Antiemetics; Arrhythmias, Cardiac; Droperidol; Fatal Outcome; Female; Humans; Long QT Syndrome | 2013 |
Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Arrhythmias, Cardiac; Consumer Product Safety; | 2010 |
The clinical significance of QT interval prolongation in anesthesia and pain management: what you should and should not worry about.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anesthetics, Inhalation; Droperidol; Humans; Long QT Synd | 2012 |
Droperidol, QT prolongation, and sudden death: what is the evidence?
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Antipsychotic Agents; Causality; Death, Sudden | 2003 |
Droperidol in the emergency department: is it safe?
Topics: Antiemetics; Antipsychotic Agents; Death, Sudden, Cardiac; Droperidol; Drug Labeling; Emergency Trea | 2003 |
Safety of droperidol in behavioural emergencies.
Topics: Adjuvants, Anesthesia; Antipsychotic Agents; Droperidol; Drug Labeling; Emergency Services, Psychiat | 2004 |
Droperidol's effect on QT interval.
Topics: Adjuvants, Anesthesia; Adverse Drug Reaction Reporting Systems; Antiemetics; Contraindications; Drop | 2006 |
Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalati | 2008 |
4 trials available for droperidol and Long QT Syndrome
| Article | Year |
|---|---|
Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.
Topics: Adolescent; Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Droperidol; E | 2015 |
Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study.
Topics: Adult; Antiemetics; Area Under Curve; Cross-Over Studies; Double-Blind Method; Droperidol; Drug Inte | 2008 |
The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Topics: Ambulatory Surgical Procedures; Antiemetics; Child, Preschool; Droperidol; Electrocardiography; Fema | 2010 |
Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study.
Topics: Adult; Anesthesia, General; Double-Blind Method; Droperidol; Female; Follow-Up Studies; Humans; Intr | 2005 |
34 other studies available for droperidol and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Prospective real-time evaluation of the QTc interval variation after low-dose droperidol among emergency department patients.
Topics: Adjuvants, Anesthesia; Adult; Antiemetics; Dose-Response Relationship, Drug; Droperidol; Emergency S | 2022 |
Emergency medicine updates: Droperidol.
Topics: Droperidol; Emergency Medicine; Headache; Humans; Long QT Syndrome; Nausea; Torsades de Pointes; Uni | 2022 |
The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department.
Topics: Adult; Critical Illness; Droperidol; Electrocardiography; Emergency Service, Hospital; Female; Human | 2020 |
Comment on "The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department".
Topics: Droperidol; Emergency Service, Hospital; Humans; Incidence; Long QT Syndrome | 2021 |
Droperidol transiently prolongs the QT interval in children undergoing single ventricle palliation.
Topics: Adjuvants, Anesthesia; Child; Child, Preschool; Droperidol; Electrocardiography; Female; Heart Defec | 2015 |
Droperidol: past, present and future.
Topics: Anesthesiology; Antiemetics; Droperidol; Drug Administration Schedule; Drug Therapy, Combination; Hu | 2009 |
The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome.
Topics: Action Potentials; Adult; Animals; Anti-Arrhythmia Agents; Antiemetics; Cardioplegic Solutions; Cell | 2010 |
[Low-dose droperidol in children: rescue therapy for persistent postoperative nausea and vomiting].
Topics: Adolescent; Antiemetics; Child; Databases, Factual; Dexamethasone; Dose-Response Relationship, Drug; | 2012 |
News flash: Old Mother Hubbard reports the cupboard is bare...time for the FDA to let droperidol out of the (black) box.
Topics: Antiemetics; Droperidol; Drug Labeling; Emergency Service, Hospital; Long QT Syndrome; Nausea; Unite | 2012 |
FDA "black box" labeling.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Antipsychotic Agents; Arrhythmias, Cardiac; Dr | 2003 |
Vestibular neuritis.
Topics: Droperidol; Drug Labeling; Humans; Long QT Syndrome; Torsades de Pointes; Vestibular Neuronitis | 2003 |
[Droperidol and cardiac arrhythmias].
Topics: Adjuvants, Anesthesia; Antiemetics; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Droper | 2003 |
Reviewing case reports and the droperidol warning: FDA response.
Topics: Adjuvants, Anesthesia; Droperidol; Humans; Injections, Intravenous; Long QT Syndrome; Product Survei | 2003 |
FDA advisory panel discusses droperidol concerns.
Topics: Advisory Committees; Droperidol; Drug Labeling; Humans; Long QT Syndrome; Product Surveillance, Post | 2004 |
A model for evaluating droperidol's effect on the median QTc interval.
Topics: Algorithms; Antiemetics; Dose-Response Relationship, Drug; Droperidol; Electrocardiography; Heart Ra | 2004 |
Ziprasidone for sedation of the agitated ED patient.
Topics: Antipsychotic Agents; Droperidol; Drug Labeling; Emergency Treatment; Humans; Long QT Syndrome; Pipe | 2004 |
Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia.
Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Dr | 2004 |
You (still) can't disprove the existence of dragons.
Topics: Droperidol; Drug Labeling; Humans; Long QT Syndrome; United States; United States Food and Drug Admi | 2005 |
Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron.
Topics: Adult; Droperidol; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Ondanse | 2005 |
Some points regarding anesthesia for patients with congenital long QT syndrome.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics; Droperidol; Humans; Long QT Syndrome | 2005 |
Drug-induced prolongation of the QT interval: what's the point?
Topics: Antiemetics; Droperidol; Electrocardiography; Humans; Long QT Syndrome; Postoperative Nausea and Vom | 2006 |
Droperidol has been reported to cause serious arrhythmias.
Topics: Antiemetics; Arrhythmias, Cardiac; Droperidol; Humans; Long QT Syndrome | 2006 |
[Long QT syndrome].
Topics: Antiemetics; Droperidol; Drug Labeling; Humans; Long QT Syndrome; Perioperative Care; Product Survei | 2006 |
Droperidol-induced proarrhythmia: the beginning of an answer?
Topics: Adjuvants, Anesthesia; Droperidol; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Potas | 2007 |
Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?
Topics: Adjuvants, Anesthesia; Anesthesia, General; Antiemetics; Droperidol; Electrocardiography; Long QT Sy | 2007 |
Sufficiency of data for resuming use of low-dose droperidol.
Topics: Antiemetics; Droperidol; Humans; Long QT Syndrome; Vomiting | 2008 |
Pro: The Food and Drug Administration Black box warning on droperidol is not justified.
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
Con: The black box warning on droperidol should not be removed (but should be clarified!).
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
FDA response to droperidol black box warning editorials.
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
The black box warning for droperidol.
Topics: Antiemetics; Droperidol; Humans; Long QT Syndrome; Nerve Block; Torsades de Pointes | 2008 |
Warnings strengthened on tranquilizer inapsine (Droperidol).
Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Droperidol; Humans; Long QT Syndrome; Produc | 2001 |
Droperidol--behind the black box warning.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Dose-Response Relationship, Drug; Droperidol; | 2002 |
[Torsades de pointes and prolongation of the duration of QT interval after injection of droperidol].
Topics: Adult; Aged; Aged, 80 and over; Droperidol; Electrocardiography; Female; Humans; Long QT Syndrome; M | 1991 |