droperidol has been researched along with Innate Inflammatory Response in 4 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| YELNOSKY, J | 1 |
| FIELD, WE | 1 |
| Wan, Y | 1 |
| Xu, J | 1 |
| Ma, D | 1 |
| Zeng, Y | 1 |
| Cibelli, M | 1 |
| Maze, M | 1 |
| Newton, WM | 1 |
| Cusick, PK | 1 |
| Raffe, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia (POCD-MRI)[NCT02045004] | 100 participants (Actual) | Observational | 2015-07-14 | Completed | |||
| Release of Serum Neurofilament Light (NFL), Biomarker of Neuronal Injury, in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp): A Prospective, Non-inferiority Study[NCT04500236] | 100 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | |||
| Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692] | Phase 3 | 750 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | ||
| Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section[NCT03818009] | 58 participants (Actual) | Observational | 2019-01-14 | Completed | |||
| Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial[NCT02267538] | Phase 4 | 285 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Effect of Remifentanil on Postoperative Cognitive Function in Patients Undergoing Major Abdominal Surgery[NCT01627873] | Phase 4 | 622 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) twice daily during the first five days after surgery. (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| DEX Group | 7 |
| CTRL Group | 11 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from hospital or 30 days after surgery
| Intervention | days (Median) |
|---|---|
| DEX Group | 9 |
| CTRL Group | 9 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from Intensive Care Unit or 30 days after surgery
| Intervention | hours (Median) |
|---|---|
| DEX Group | 45.0 |
| CTRL Group | 46.0 |
"Cognitive function was assessed with the Mini Mental State Examination (MMSE) at baseline (the day before surgery) and on the sixth day after surgery, and with modified telephone interview for cognitive status (m-TICS) on the 30th day after surgery.~The introduction of MMSE scale has been explained in the baseline part in the result section.~The Telephone Interview for Cognitive Status-modified scale(m-TICS) is one of the most popular telephone interview-based screening instruments for mild cognitive impairment and dementia. It consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis, which score ranges from 0 to 48, with higher scores indicating better cognitive function" (NCT02267538)
Timeframe: on the sixth day after surgery, and on the 30th day after surgery
| Intervention | units on a scale (Median) | |
|---|---|---|
| MMSE score on postoperative day 6 | m-TICS score on postoperative day 30 | |
| CTRL Group | 29 | 34 |
| DEX Group | 29 | 34 |
Non-delirium complications was defined as any conditions other than delirium that occurred during the first 30 days after surgery and required therapeutic intervention.Complications listed here were not considered adverse events in this study. (NCT02267538)
Timeframe: Occurrence of non-delirium complications will be monitored until 30 days after surgery.
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Stroke | New onset arrythmia | Pulmonary complications | Upper gastrointestinal bleeding | Surgical bleeding | Wound dehiscence or infection | Acute kidney injury | IABP assistance | |
| CTRL Group | 3 | 51 | 27 | 4 | 3 | 7 | 44 | 12 |
| DEX Group | 3 | 42 | 15 | 2 | 3 | 11 | 37 | 6 |
Pain intensity was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = no pain, 10 = the worst possible pain). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pain score after surgery(d1), at rest | Pain score after surgery(d2), at rest | Pain score after surgery(d3), at rest | Pain score after surgery(d4), at rest | Pain score after surgery(d5), at rest | Pain score after surgery(d1), with coughing | Pain score after surgery(d2), with coughing | Pain score after surgery(d3), with coughing | Pain score after surgery(d4), with coughing | Pain score after surgery(d5), with coughing | |
| CTRL Group | 3 | 3 | 2 | 2 | 1 | 4 | 4 | 4 | 3 | 2 |
| DEX Group | 3 | 4 | 3 | 2 | 2 | 4 | 5 | 4 | 3 | 2 |
Subjective sleep quality was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = best sleep, 10 = the worst possible sleep). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | ||||
|---|---|---|---|---|---|
| Subjective sleep quality after surgery(d1), score | Subjective sleep quality after surgery(d2), score | Subjective sleep quality after surgery(d3), score | Subjective sleep quality after surgery(d4), score | Subjective sleep quality after surgery(d5), score | |
| CTRL Group | 2 | 3 | 2 | 2 | 2 |
| DEX Group | 2 | 3 | 2 | 2 | 2 |
4 other studies available for droperidol and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
A PRELIMINARY REPORT ON THE USE OF A COMBINATION OF DROPERIDOL AND FENTANYL CITRATE IN VETERINARY MEDICINE.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Behavior, Animal; Benperidol; Birds; Ca | 1964 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Innovar-Vet-induced pathologic changes in the guinea pig.
Topics: Anesthesia; Animals; Droperidol; Female; Fentanyl; Foot; Foot Diseases; Guinea Pigs; Humans; Inflamm | 1975 |