droperidol has been researched along with Electrocardiogram QT Prolonged in 47 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP)." | 7.74 | Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ( Ackerman, MJ; Eckerman, KM; Jacob, KA; Marienau, ME; Narr, BJ; Nuttall, GA; Oliver, WC; Pawlaski, EM; Wigersma, SK, 2007) |
| "Droperidol is a highly potent butyrophenone used for the therapy of postoperative nausea and vomiting." | 5.36 | The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome. ( Ehmke, H; Friederich, P; Kebernik, J; Schwoerer, AP, 2010) |
| "When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol." | 5.33 | Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ( Albaladejo, P; Charbit, B; Funck-Brentano, C; Legrand, M; Marty, J; Samain, E, 2005) |
| "Droperidol is an effective and safe option for the treatment of acute agitation, migraine, nausea, and pain for patients in the ED setting." | 5.05 | Reintegrating droperidol into emergency medicine practice. ( Brown, CS; Cabrera, D; Friend, K; Mattson, A, 2020) |
| "Scientific studies report that there is no basis to issue a black-box warning for perioperative administration of droperidol for postoperative nausea and vomiting on the basis of the potential of adverse cardiac events (prolongation of the QT interval and/or development of torsades de pointes)." | 4.86 | Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system. ( Barash, PG; Halloran, K, 2010) |
| " In the patient described in this article, heart block occurred and the Q-Tc interval became prolonged after muscle relaxant reversal with neostigmine; both were considered to be related to the combination of agents used in the case, as well as to other predisposing factors such as morbid obesity." | 4.84 | Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report. ( Shields, JA, 2008) |
| "Current evidence suggests that droperidol is a safe and effective medication for treating nausea and vomiting, headache, vertigo, and agitation in the ED setting." | 4.12 | Emergency medicine updates: Droperidol. ( Cisewski, D; Gottlieb, M; Long, B, 2022) |
| "The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP)." | 3.74 | Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ( Ackerman, MJ; Eckerman, KM; Jacob, KA; Marienau, ME; Narr, BJ; Nuttall, GA; Oliver, WC; Pawlaski, EM; Wigersma, SK, 2007) |
| "The statistically significant prolongation of QTc time after a sedative dose of droperidol is of concern because it may increase the risk for malignant cardiac arrhythmias." | 3.72 | Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. ( Berens, RJ; Cava, JR; Hoffman, GM; Stucke, AG; Stuth, EA, 2004) |
| "Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization." | 2.80 | Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study. ( Owczuk, R; Tracz, K, 2015) |
| "Droperidol is a butyrophenone commonly used as an antiemetic and antipsychotic in the United States since US Food and Drug Administration (FDA) approval in 1970." | 2.42 | Droperidol, QT prolongation, and sudden death: what is the evidence? ( Evers, SJ; Kao, LW; Kirk, MA; Rosenfeld, SH, 2003) |
| "Droperidol is an antipsychotic and antiemetic drug that has been used extensively by emergency physicians, psychiatrists, and anesthesiologists worldwide since 1967." | 2.42 | Droperidol in the emergency department: is it safe? ( Richards, JR; Schneir, AB, 2003) |
| "Droperidol is a highly potent butyrophenone used for the therapy of postoperative nausea and vomiting." | 1.36 | The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome. ( Ehmke, H; Friederich, P; Kebernik, J; Schwoerer, AP, 2010) |
| "When used in treatment of postoperative nausea and vomiting, a situation where prolongation of the QTc interval seems to occur, the safety of 5-hydroxytryptamine type 3 antagonists may not be superior to that of low-dose droperidol." | 1.33 | Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ( Albaladejo, P; Charbit, B; Funck-Brentano, C; Legrand, M; Marty, J; Samain, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 32 (68.09) | 29.6817 |
| 2010's | 9 (19.15) | 24.3611 |
| 2020's | 5 (10.64) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Hernández-Rodríguez, L | 1 |
| Bellolio, F | 1 |
| Cabrera, D | 2 |
| Mattson, AE | 1 |
| VanMeter, D | 1 |
| Grush, AE | 1 |
| Oliveira J E Silva, L | 1 |
| Cisewski, D | 1 |
| Long, B | 1 |
| Gottlieb, M | 1 |
| Cole, JB | 1 |
| Lee, SC | 1 |
| Martel, ML | 2 |
| Smith, SW | 1 |
| Biros, MH | 1 |
| Miner, JR | 1 |
| Mattson, A | 1 |
| Friend, K | 1 |
| Brown, CS | 1 |
| DiSalvo, PC | 1 |
| Backus, TC | 1 |
| Chiang, WK | 1 |
| Patel, J | 1 |
| Scott, JP | 1 |
| Stuth, EA | 2 |
| Stucke, AG | 2 |
| Cava, JR | 2 |
| Berens, RJ | 2 |
| Tracz, K | 1 |
| Owczuk, R | 1 |
| Charbit, B | 3 |
| Alvarez, JC | 1 |
| Dasque, E | 1 |
| Abe, E | 1 |
| Démolis, JL | 1 |
| Funck-Brentano, C | 3 |
| Sneyd, JR | 1 |
| Halloran, K | 1 |
| Barash, PG | 1 |
| Schwoerer, AP | 1 |
| Kebernik, J | 1 |
| Ehmke, H | 1 |
| Friederich, P | 1 |
| Mehta, D | 1 |
| Sanatani, S | 1 |
| Whyte, SD | 1 |
| Schroeter, E | 1 |
| Schmitz, A | 1 |
| Haas, T | 1 |
| Weiss, M | 1 |
| Gerber, AC | 1 |
| Spevak, C | 1 |
| Hamsher, C | 1 |
| Brown, CQ | 1 |
| Wedam, EF | 1 |
| Haigney, MC | 1 |
| Faine, B | 1 |
| Hogrefe, C | 1 |
| Kao, LW | 1 |
| Kirk, MA | 1 |
| Evers, SJ | 1 |
| Rosenfeld, SH | 1 |
| Meyer, RJ | 1 |
| Richards, JR | 1 |
| Schneir, AB | 1 |
| Orr, EJ | 1 |
| Gómez-Arnau, JI | 1 |
| Chang, N | 1 |
| Simone, A | 1 |
| Schultheis, L | 1 |
| Rappaport, B | 1 |
| Young, D | 1 |
| Zhang, Y | 1 |
| Luo, Z | 1 |
| White, PF | 3 |
| Shale, JH | 1 |
| Shale, CM | 1 |
| Mastin, WD | 1 |
| Hoffman, GM | 1 |
| Scuderi, PE | 1 |
| Albaladejo, P | 1 |
| Legrand, M | 1 |
| Samain, E | 1 |
| Marty, J | 1 |
| Song, D | 1 |
| Abrao, J | 2 |
| Klein, KW | 1 |
| Navarette, B | 1 |
| Katz, RI | 1 |
| Sosis, MB | 2 |
| Martinez, JB | 1 |
| Moos, DD | 1 |
| Dahlen, LL | 1 |
| Zbinden, S | 1 |
| Nuttall, GA | 1 |
| Eckerman, KM | 1 |
| Jacob, KA | 1 |
| Pawlaski, EM | 1 |
| Wigersma, SK | 1 |
| Marienau, ME | 1 |
| Oliver, WC | 1 |
| Narr, BJ | 1 |
| Ackerman, MJ | 1 |
| Wyllie, AR | 1 |
| Carvalhana, VV | 1 |
| Burry, LD | 1 |
| Teresi, JE | 1 |
| Shields, JA | 1 |
| Habib, AS | 1 |
| Gan, TJ | 1 |
| Ludwin, DB | 1 |
| Shafer, SL | 1 |
| Rappaport, BA | 1 |
| SoRelle, R | 1 |
| Horowitz, BZ | 1 |
| Bizovi, K | 1 |
| Moreno, R | 1 |
| Guy, JM | 1 |
| André-Fouet, X | 1 |
| Porte, J | 1 |
| Bertrand, M | 1 |
| Lamaud, M | 1 |
| Verneyre, H | 1 |
9 reviews available for droperidol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Reintegrating droperidol into emergency medicine practice.
Topics: Dose-Response Relationship, Drug; Droperidol; Drug Labeling; Drug Monitoring; Drug Utilization; Emer | 2020 |
Droperidol- and ondansetron-induced life-threatening arrhythmias.
Topics: Aged; Antiemetics; Arrhythmias, Cardiac; Droperidol; Fatal Outcome; Female; Humans; Long QT Syndrome | 2013 |
Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Arrhythmias, Cardiac; Consumer Product Safety; | 2010 |
The clinical significance of QT interval prolongation in anesthesia and pain management: what you should and should not worry about.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anesthetics, Inhalation; Droperidol; Humans; Long QT Synd | 2012 |
Droperidol, QT prolongation, and sudden death: what is the evidence?
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Antipsychotic Agents; Causality; Death, Sudden | 2003 |
Droperidol in the emergency department: is it safe?
Topics: Antiemetics; Antipsychotic Agents; Death, Sudden, Cardiac; Droperidol; Drug Labeling; Emergency Trea | 2003 |
Safety of droperidol in behavioural emergencies.
Topics: Adjuvants, Anesthesia; Antipsychotic Agents; Droperidol; Drug Labeling; Emergency Services, Psychiat | 2004 |
Droperidol's effect on QT interval.
Topics: Adjuvants, Anesthesia; Adverse Drug Reaction Reporting Systems; Antiemetics; Contraindications; Drop | 2006 |
Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalati | 2008 |
4 trials available for droperidol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Small doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.
Topics: Adolescent; Adult; Antiemetics; Dose-Response Relationship, Drug; Double-Blind Method; Droperidol; E | 2015 |
Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study.
Topics: Adult; Antiemetics; Area Under Curve; Cross-Over Studies; Double-Blind Method; Droperidol; Drug Inte | 2008 |
The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Topics: Ambulatory Surgical Procedures; Antiemetics; Child, Preschool; Droperidol; Electrocardiography; Fema | 2010 |
Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study.
Topics: Adult; Anesthesia, General; Double-Blind Method; Droperidol; Female; Follow-Up Studies; Humans; Intr | 2005 |
34 other studies available for droperidol and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Prospective real-time evaluation of the QTc interval variation after low-dose droperidol among emergency department patients.
Topics: Adjuvants, Anesthesia; Adult; Antiemetics; Dose-Response Relationship, Drug; Droperidol; Emergency S | 2022 |
Emergency medicine updates: Droperidol.
Topics: Droperidol; Emergency Medicine; Headache; Humans; Long QT Syndrome; Nausea; Torsades de Pointes; Uni | 2022 |
The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department.
Topics: Adult; Critical Illness; Droperidol; Electrocardiography; Emergency Service, Hospital; Female; Human | 2020 |
Comment on "The Incidence of QT Prolongation and Torsades des Pointes in Patients Receiving Droperidol in an Urban Emergency Department".
Topics: Droperidol; Emergency Service, Hospital; Humans; Incidence; Long QT Syndrome | 2021 |
Droperidol transiently prolongs the QT interval in children undergoing single ventricle palliation.
Topics: Adjuvants, Anesthesia; Child; Child, Preschool; Droperidol; Electrocardiography; Female; Heart Defec | 2015 |
Droperidol: past, present and future.
Topics: Anesthesiology; Antiemetics; Droperidol; Drug Administration Schedule; Drug Therapy, Combination; Hu | 2009 |
The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome.
Topics: Action Potentials; Adult; Animals; Anti-Arrhythmia Agents; Antiemetics; Cardioplegic Solutions; Cell | 2010 |
[Low-dose droperidol in children: rescue therapy for persistent postoperative nausea and vomiting].
Topics: Adolescent; Antiemetics; Child; Databases, Factual; Dexamethasone; Dose-Response Relationship, Drug; | 2012 |
News flash: Old Mother Hubbard reports the cupboard is bare...time for the FDA to let droperidol out of the (black) box.
Topics: Antiemetics; Droperidol; Drug Labeling; Emergency Service, Hospital; Long QT Syndrome; Nausea; Unite | 2012 |
FDA "black box" labeling.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Antipsychotic Agents; Arrhythmias, Cardiac; Dr | 2003 |
Vestibular neuritis.
Topics: Droperidol; Drug Labeling; Humans; Long QT Syndrome; Torsades de Pointes; Vestibular Neuronitis | 2003 |
[Droperidol and cardiac arrhythmias].
Topics: Adjuvants, Anesthesia; Antiemetics; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Droper | 2003 |
Reviewing case reports and the droperidol warning: FDA response.
Topics: Adjuvants, Anesthesia; Droperidol; Humans; Injections, Intravenous; Long QT Syndrome; Product Survei | 2003 |
FDA advisory panel discusses droperidol concerns.
Topics: Advisory Committees; Droperidol; Drug Labeling; Humans; Long QT Syndrome; Product Surveillance, Post | 2004 |
A model for evaluating droperidol's effect on the median QTc interval.
Topics: Algorithms; Antiemetics; Dose-Response Relationship, Drug; Droperidol; Electrocardiography; Heart Ra | 2004 |
Ziprasidone for sedation of the agitated ED patient.
Topics: Antipsychotic Agents; Droperidol; Drug Labeling; Emergency Treatment; Humans; Long QT Syndrome; Pipe | 2004 |
Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia.
Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Dr | 2004 |
You (still) can't disprove the existence of dragons.
Topics: Droperidol; Drug Labeling; Humans; Long QT Syndrome; United States; United States Food and Drug Admi | 2005 |
Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron.
Topics: Adult; Droperidol; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Ondanse | 2005 |
Some points regarding anesthesia for patients with congenital long QT syndrome.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics; Droperidol; Humans; Long QT Syndrome | 2005 |
Drug-induced prolongation of the QT interval: what's the point?
Topics: Antiemetics; Droperidol; Electrocardiography; Humans; Long QT Syndrome; Postoperative Nausea and Vom | 2006 |
Droperidol has been reported to cause serious arrhythmias.
Topics: Antiemetics; Arrhythmias, Cardiac; Droperidol; Humans; Long QT Syndrome | 2006 |
[Long QT syndrome].
Topics: Antiemetics; Droperidol; Drug Labeling; Humans; Long QT Syndrome; Perioperative Care; Product Survei | 2006 |
Droperidol-induced proarrhythmia: the beginning of an answer?
Topics: Adjuvants, Anesthesia; Droperidol; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Potas | 2007 |
Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?
Topics: Adjuvants, Anesthesia; Anesthesia, General; Antiemetics; Droperidol; Electrocardiography; Long QT Sy | 2007 |
Sufficiency of data for resuming use of low-dose droperidol.
Topics: Antiemetics; Droperidol; Humans; Long QT Syndrome; Vomiting | 2008 |
Pro: The Food and Drug Administration Black box warning on droperidol is not justified.
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
Con: The black box warning on droperidol should not be removed (but should be clarified!).
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
FDA response to droperidol black box warning editorials.
Topics: Antiemetics; Consumer Product Safety; Dose-Response Relationship, Drug; Droperidol; Drug Approval; D | 2008 |
The black box warning for droperidol.
Topics: Antiemetics; Droperidol; Humans; Long QT Syndrome; Nerve Block; Torsades de Pointes | 2008 |
Warnings strengthened on tranquilizer inapsine (Droperidol).
Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Droperidol; Humans; Long QT Syndrome; Produc | 2001 |
Droperidol--behind the black box warning.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Dose-Response Relationship, Drug; Droperidol; | 2002 |
[Torsades de pointes and prolongation of the duration of QT interval after injection of droperidol].
Topics: Adult; Aged; Aged, 80 and over; Droperidol; Electrocardiography; Female; Humans; Long QT Syndrome; M | 1991 |