Compounds > droperidol
Page last updated: 2024-10-26

droperidol and Disease Models, Animal

droperidol has been researched along with Disease Models, Animal in 9 studies

Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"Excessive blood loss in a rat model of uncontrolled hemorrhage has been attributed to the vasodilatory effects of a droperidol-ketamine mixture used for anesthesia."3.69Effects of anesthesia on a model of uncontrolled hemorrhage in rats. ( Barber, A; Greene, SP; Illner, H; Shires, GT; Sindlinger, JF; Soucy, DM, 1995)
" Dose-response curves were also obtained with tramadol combined with ondansetron or droperidol at 1:1 fixed ratios."1.33Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice. ( Dürsteler, C; Fernandez, V; Mases, A; Pol, O; Puig, MM, 2006)
"Torsades de pointes have been observed during treatment with droperidol, a butyrophenone neuroleptic agent."1.30Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current. ( Deschênes, D; Drolet, B; January, CT; Nadeau, S; Rail, J; Turgeon, J; Zhang, S; Zhou, Z, 1999)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's1 (11.11)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Gao, HR1
Shi, TF1
Yang, CX1
Zhang, D1
Zhang, GW1
Zhang, Y2
Jiao, RS1
Zhang, H1
Xu, MY2
Talalaenko, AN1
Pankrat'ev, DV1
Goncharenko, NV1
Dürsteler, C1
Mases, A1
Fernandez, V1
Pol, O1
Puig, MM1
Wan, Y1
Xu, J1
Ma, D1
Zeng, Y1
Cibelli, M1
Maze, M1
Su, J1
Soucy, DM1
Sindlinger, JF1
Greene, SP1
Barber, A1
Illner, H1
Shires, GT1
Drolet, B1
Zhang, S1
Deschênes, D1
Rail, J1
Nadeau, S1
Zhou, Z1
January, CT1
Turgeon, J1
Akerman, M1
Arfel, G1
de Pommery, J1
Arrouvel, C1
Sirvys, A1
Vourc'h, G1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia (POCD-MRI)[NCT02045004]100 participants (Actual)Observational2015-07-14Completed
Release of Serum Neurofilament Light (NFL), Biomarker of Neuronal Injury, in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp): A Prospective, Non-inferiority Study[NCT04500236]100 participants (Anticipated)Interventional2020-09-01Recruiting
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692]Phase 3750 participants (Anticipated)Interventional2016-11-30Recruiting
Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section[NCT03818009]58 participants (Actual)Observational2019-01-14Completed
Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial[NCT02267538]Phase 4285 participants (Actual)Interventional2014-11-30Completed
Effect of Remifentanil on Postoperative Cognitive Function in Patients Undergoing Major Abdominal Surgery[NCT01627873]Phase 4622 participants (Actual)Interventional2009-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Postoperative Delirium

Delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) twice daily during the first five days after surgery. (NCT02267538)
Timeframe: During the first five days after surgery

InterventionParticipants (Count of Participants)
DEX Group7
CTRL Group11

Length of Stay in Hospital After Surgery

Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from hospital or 30 days after surgery

Interventiondays (Median)
DEX Group9
CTRL Group9

Length of Stay in the Intensive Care Unit

Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from Intensive Care Unit or 30 days after surgery

Interventionhours (Median)
DEX Group45.0
CTRL Group46.0

Cognitive Function

"Cognitive function was assessed with the Mini Mental State Examination (MMSE) at baseline (the day before surgery) and on the sixth day after surgery, and with modified telephone interview for cognitive status (m-TICS) on the 30th day after surgery.~The introduction of MMSE scale has been explained in the baseline part in the result section.~The Telephone Interview for Cognitive Status-modified scale(m-TICS) is one of the most popular telephone interview-based screening instruments for mild cognitive impairment and dementia. It consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis, which score ranges from 0 to 48, with higher scores indicating better cognitive function" (NCT02267538)
Timeframe: on the sixth day after surgery, and on the 30th day after surgery

,
Interventionunits on a scale (Median)
MMSE score on postoperative day 6m-TICS score on postoperative day 30
CTRL Group2934
DEX Group2934

Incidence of Non-delirium Complications After Surgery

Non-delirium complications was defined as any conditions other than delirium that occurred during the first 30 days after surgery and required therapeutic intervention.Complications listed here were not considered adverse events in this study. (NCT02267538)
Timeframe: Occurrence of non-delirium complications will be monitored until 30 days after surgery.

,
InterventionParticipants (Count of Participants)
StrokeNew onset arrythmiaPulmonary complicationsUpper gastrointestinal bleedingSurgical bleedingWound dehiscence or infectionAcute kidney injuryIABP assistance
CTRL Group351274374412
DEX Group342152311376

Pain Intensity

Pain intensity was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = no pain, 10 = the worst possible pain). (NCT02267538)
Timeframe: During the first five days after surgery

,
Interventionunits on a scale (Median)
Pain score after surgery(d1), at restPain score after surgery(d2), at restPain score after surgery(d3), at restPain score after surgery(d4), at restPain score after surgery(d5), at restPain score after surgery(d1), with coughingPain score after surgery(d2), with coughingPain score after surgery(d3), with coughingPain score after surgery(d4), with coughingPain score after surgery(d5), with coughing
CTRL Group3322144432
DEX Group3432245432

Subjective Sleep Quality

Subjective sleep quality was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = best sleep, 10 = the worst possible sleep). (NCT02267538)
Timeframe: During the first five days after surgery

,
Interventionunits on a scale (Median)
Subjective sleep quality after surgery(d1), scoreSubjective sleep quality after surgery(d2), scoreSubjective sleep quality after surgery(d3), scoreSubjective sleep quality after surgery(d4), scoreSubjective sleep quality after surgery(d5), score
CTRL Group23222
DEX Group23222

Other Studies

9 other studies available for droperidol and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
The effect of dopamine on pain-related neurons in the parafascicular nucleus of rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:5

    Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Dopamine Antagonists; Droperidol; Elec

2010
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
    Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-

2003
Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice.
    European journal of pain (London, England), 2006, Volume: 10, Issue:7

    Topics: Analgesics, Opioid; Animals; Antiemetics; Disease Models, Animal; Dose-Response Relationship, Drug;

2006
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Differential effects of dopamine on pain-related electric activities in normal rats and morphinistic rats.
    Neuroscience bulletin, 2007, Volume: 23, Issue:3

    Topics: Action Potentials; Analysis of Variance; Animals; Caudate Nucleus; Disease Models, Animal; Dopamine;

2007
Effects of anesthesia on a model of uncontrolled hemorrhage in rats.
    Critical care medicine, 1995, Volume: 23, Issue:9

    Topics: Analysis of Variance; Anesthetics; Animals; Disease Models, Animal; Droperidol; Drug Combinations; F

1995
Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current.
    Journal of cardiovascular electrophysiology, 1999, Volume: 10, Issue:12

    Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine Antagonists; Droperidol; Electrocardiog

1999
[Experimental study of the cerebrovascular effects of sodium nitroprusside in the baboon Papio papio. Its action on the experimental vasospasm].
    Neuro-Chirurgie, 1976, Volume: 22, Issue:1

    Topics: Acid-Base Equilibrium; Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Circulation

1976