droperidol has been researched along with Bilateral Headache in 14 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective was to determine if there is a difference in pain relief or frequency and severity of side effects in emergency department (ED) patients with primary headache treated with either intramuscular (IM) olanzapine or IM droperidol." | 9.13 | Olanzapine versus droperidol for the treatment of primary headache in the emergency department. ( Hill, CH; Martel, ML; Miner, JR, 2008) |
| "To compare the efficacy of droperidol with that of prochlorperazine for the treatment of benign headaches in emergency department (ED) patients." | 9.09 | Droperidol vs. prochlorperazine for benign headaches in the emergency department. ( Biros, MH; Fish, SJ; Miner, JR; Smith, SW, 2001) |
| "This prospective, randomized, double-blinded study evaluated the antiemetic efficacy of granisetron and droperidol in 80 ASA physical status I children, aged 4-10 years, undergoing strabismus surgery or tonsillectomy with or without adenoidectomy." | 9.08 | Comparison of granisetron and droperidol in the prevention of vomiting after strabismus surgery or tonsillectomy in children. ( Fujii, Y; Saitoh, Y; Tanaka, H; Toyooka, H, 1998) |
| "The aim of this study was to describe the use and efficacy of low-dose (≤2 mg) droperidol for the treatment of primary headaches (ie, migraine, cluster, tension-type headache and trigeminal autonomic cephalalgias, and other primary headaches) in the emergency department (ED)." | 7.78 | Treating primary headaches in the ED: can droperidol regain its role? ( Faine, B; Hogrefe, C; Smelser, J; Van Heukelom, J, 2012) |
| "Headache is a common presenting complaint to the ED." | 5.72 | Patients treated for acute headache with intranasal droperidol spend less time in the emergency department: A retrospective observational study. ( Bruce, E; Hammond, S; Holland, A; King, C; Knight, A; Munro, A; Stacey, J; Stern, A, 2022) |
| "The objective was to determine if there is a difference in pain relief or frequency and severity of side effects in emergency department (ED) patients with primary headache treated with either intramuscular (IM) olanzapine or IM droperidol." | 5.13 | Olanzapine versus droperidol for the treatment of primary headache in the emergency department. ( Hill, CH; Martel, ML; Miner, JR, 2008) |
| "To compare the efficacy of droperidol with that of prochlorperazine for the treatment of benign headaches in emergency department (ED) patients." | 5.09 | Droperidol vs. prochlorperazine for benign headaches in the emergency department. ( Biros, MH; Fish, SJ; Miner, JR; Smith, SW, 2001) |
| "More than 2000 patients at high risk of postoperative nausea and vomiting were given either placebo, ondansetron 4 mg, or droperidol 0." | 5.08 | A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. S3A-409 and S3A-410 Study Groups. ( Creed, MR; Duncan, B; Fortney, JT; Gan, TJ; Glass, PS; Graczyk, S; Khalil, S; McKenzie, R; Melson, T; Moote, C; Parasuraman, TV; Parrillo, S; Wermeling, D; Wetchler, B, 1998) |
| "This prospective, randomized, double-blinded study evaluated the antiemetic efficacy of granisetron and droperidol in 80 ASA physical status I children, aged 4-10 years, undergoing strabismus surgery or tonsillectomy with or without adenoidectomy." | 5.08 | Comparison of granisetron and droperidol in the prevention of vomiting after strabismus surgery or tonsillectomy in children. ( Fujii, Y; Saitoh, Y; Tanaka, H; Toyooka, H, 1998) |
| " Atropine plus droperidol was superior to atropine plus diazepam or atropine alone in lessening nausea and vomiting and in reducing the need for postoperative analgesia." | 5.04 | Double-blind clinical trial of anaesthetic premedication for use in major day surgery. ( Davie, IT; Espley, AJ; Prescott, RJ; Ruckley, CV; Slawson, KB, 1976) |
| "Droperidol is an effective and safe medication in the treatment of nausea, headache, and agitation." | 4.91 | American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department. ( DeMers, G; Ho, JD; Perkins, J; Vilke, GM, 2015) |
| "Included studies were randomized trials of a parenteral butyrophenone (droperidol, haloperidol) versus placebo or a comparator in migraine or benign headache with results available in English." | 4.87 | Are butyrophenones effective for the treatment of primary headache in the emergency department? ( Kelly, AM; Leong, LB, 2011) |
| "Current evidence suggests that droperidol is a safe and effective medication for treating nausea and vomiting, headache, vertigo, and agitation in the ED setting." | 4.12 | Emergency medicine updates: Droperidol. ( Cisewski, D; Gottlieb, M; Long, B, 2022) |
| "The aim of this study was to describe the use and efficacy of low-dose (≤2 mg) droperidol for the treatment of primary headaches (ie, migraine, cluster, tension-type headache and trigeminal autonomic cephalalgias, and other primary headaches) in the emergency department (ED)." | 3.78 | Treating primary headaches in the ED: can droperidol regain its role? ( Faine, B; Hogrefe, C; Smelser, J; Van Heukelom, J, 2012) |
| " Indications for droperidol included agitation, 68 (86%); nausea/vomiting, 7 (9%); headache, 2 (3%); and other pain, 2 (3%)." | 3.76 | Droperidol use in pediatric emergency department patients. ( Sacchetti, A; Szwak, K, 2010) |
| "Headache is a common presenting complaint to the ED." | 1.72 | Patients treated for acute headache with intranasal droperidol spend less time in the emergency department: A retrospective observational study. ( Bruce, E; Hammond, S; Holland, A; King, C; Knight, A; Munro, A; Stacey, J; Stern, A, 2022) |
| "Droperidol is a dopamine receptor antagonist that functions as an analgesic, sedative, and antiemetic." | 1.56 | Effectiveness and safety of droperidol in a United States emergency department. ( Bellolio, F; Cabrera, D; Gaw, CM; Jeffery, MM; Lohse, CM; Mattson, AE, 2020) |
| "There was no difference in the treatments used or pain relief achieved between migraine, migrainous, and tension-type headaches." | 1.35 | Pain treatment and relief among patients with primary headache subtypes in the ED. ( Miner, J; Trainor, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Cisewski, D | 1 |
| Long, B | 1 |
| Gottlieb, M | 1 |
| Stern, A | 1 |
| Munro, A | 1 |
| King, C | 1 |
| Knight, A | 1 |
| Bruce, E | 1 |
| Stacey, J | 1 |
| Hammond, S | 1 |
| Holland, A | 1 |
| Gaw, CM | 1 |
| Cabrera, D | 1 |
| Bellolio, F | 1 |
| Mattson, AE | 1 |
| Lohse, CM | 1 |
| Jeffery, MM | 1 |
| Perkins, J | 1 |
| Ho, JD | 1 |
| Vilke, GM | 1 |
| DeMers, G | 1 |
| Trainor, A | 1 |
| Miner, J | 1 |
| Hill, CH | 1 |
| Miner, JR | 2 |
| Martel, ML | 1 |
| Szwak, K | 1 |
| Sacchetti, A | 1 |
| Leong, LB | 1 |
| Kelly, AM | 1 |
| Faine, B | 1 |
| Hogrefe, C | 1 |
| Van Heukelom, J | 1 |
| Smelser, J | 1 |
| Weaver, CS | 1 |
| Jones, JB | 1 |
| Chisholm, CD | 1 |
| Foley, MJ | 1 |
| Giles, BK | 1 |
| Somerville, GG | 1 |
| Brizendine, EJ | 1 |
| Cordell, WH | 1 |
| Fortney, JT | 1 |
| Gan, TJ | 1 |
| Graczyk, S | 1 |
| Wetchler, B | 1 |
| Melson, T | 1 |
| Khalil, S | 1 |
| McKenzie, R | 1 |
| Parrillo, S | 1 |
| Glass, PS | 1 |
| Moote, C | 1 |
| Wermeling, D | 1 |
| Parasuraman, TV | 1 |
| Duncan, B | 1 |
| Creed, MR | 1 |
| Fujii, Y | 1 |
| Saitoh, Y | 1 |
| Tanaka, H | 1 |
| Toyooka, H | 1 |
| Fish, SJ | 1 |
| Smith, SW | 1 |
| Biros, MH | 1 |
| Prescott, RJ | 1 |
| Espley, AJ | 1 |
| Davie, IT | 1 |
| Slawson, KB | 1 |
| Ruckley, CV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708] | 233 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031] | Phase 4 | 54 participants (Actual) | Interventional | 2016-03-17 | Completed | ||
| Intravenous Fluids in Benign Headaches Trail: A Randomized Single Blind Clinical Trial[NCT03185130] | Phase 4 | 58 participants (Actual) | Interventional | 2017-05-16 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours
| Intervention | hours (Median) |
|---|---|
| Intervention Cohort | 26.4 |
| Comparison Cohort | 28.2 |
To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital
| Intervention | percentage of subjects with PDN (Number) |
|---|---|
| Intervention Cohort | 72 |
| Comparison Cohort | 60 |
(NCT01592708)
Timeframe: 1 week post discharge
| Intervention | percentage of subjects with PDV (Number) |
|---|---|
| Intervention Cohort | 22 |
| Comparison Cohort | 29 |
End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with PON (Number) |
|---|---|
| Intervention Cohort | 24 |
| Comparison Cohort | 70 |
(NCT01592708)
Timeframe: End of surgery to discharge from hospital
| Intervention | percentage of subjects with POV (Number) |
|---|---|
| Intervention Cohort | 11 |
| Comparison Cohort | 28 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 33.7 |
| Study Arm | 21.2 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 63.5 |
| Study Arm | 43.5 |
Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | mm (Mean) |
|---|---|
| Control Arm | 38.9 |
| Study Arm | 22.9 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 2 |
| Study Arm | 3 |
Yes/No (NCT02657031)
Timeframe: 0-60 minutes
| Intervention | participants (Number) |
|---|---|
| Control Arm | 3 |
| Study Arm | 3 |
2 reviews available for droperidol and Bilateral Headache
| Article | Year |
|---|---|
American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department.
Topics: Dopamine D2 Receptor Antagonists; Droperidol; Electrocardiography; Emergency Medicine; Emergency Ser | 2015 |
Are butyrophenones effective for the treatment of primary headache in the emergency department?
Topics: Butyrophenones; Droperidol; Emergency Service, Hospital; Haloperidol; Headache; Humans; Migraine Dis | 2011 |
6 trials available for droperidol and Bilateral Headache
| Article | Year |
|---|---|
Olanzapine versus droperidol for the treatment of primary headache in the emergency department.
Topics: Adolescent; Adult; Benzodiazepines; Chi-Square Distribution; Dopamine Antagonists; Droperidol; Emerg | 2008 |
Droperidol vs prochlorperazine for the treatment of acute headache.
Topics: Acute Disease; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Dopamine Antagonists; | 2004 |
A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. S3A-409 and S3A-410 Study Groups.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anesthetics, Inhal | 1998 |
Comparison of granisetron and droperidol in the prevention of vomiting after strabismus surgery or tonsillectomy in children.
Topics: Adenoidectomy; Antiemetics; Child; Child, Preschool; Double-Blind Method; Droperidol; Evaluation Stu | 1998 |
Droperidol vs. prochlorperazine for benign headaches in the emergency department.
Topics: Adult; Analysis of Variance; Dopamine Antagonists; Droperidol; Emergency Service, Hospital; Female; | 2001 |
Droperidol vs. prochlorperazine for benign headaches in the emergency department.
Topics: Adult; Analysis of Variance; Dopamine Antagonists; Droperidol; Emergency Service, Hospital; Female; | 2001 |
Droperidol vs. prochlorperazine for benign headaches in the emergency department.
Topics: Adult; Analysis of Variance; Dopamine Antagonists; Droperidol; Emergency Service, Hospital; Female; | 2001 |
Droperidol vs. prochlorperazine for benign headaches in the emergency department.
Topics: Adult; Analysis of Variance; Dopamine Antagonists; Droperidol; Emergency Service, Hospital; Female; | 2001 |
Double-blind clinical trial of anaesthetic premedication for use in major day surgery.
Topics: Adult; Anesthesia, Inhalation; Atropine; Clinical Trials as Topic; Day Care, Medical; Diazepam; Drop | 1976 |
6 other studies available for droperidol and Bilateral Headache
| Article | Year |
|---|---|
Emergency medicine updates: Droperidol.
Topics: Droperidol; Emergency Medicine; Headache; Humans; Long QT Syndrome; Nausea; Torsades de Pointes; Uni | 2022 |
Patients treated for acute headache with intranasal droperidol spend less time in the emergency department: A retrospective observational study.
Topics: Adult; Droperidol; Emergency Service, Hospital; Headache; Humans; Prospective Studies; Retrospective | 2022 |
Effectiveness and safety of droperidol in a United States emergency department.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Analgesics, Opioid; Antiemetics; Arrhythmias, Cardiac; Dro | 2020 |
Pain treatment and relief among patients with primary headache subtypes in the ED.
Topics: Adolescent; Adult; Aged; Droperidol; Emergency Service, Hospital; Headache; Humans; Middle Aged; Pai | 2008 |
Droperidol use in pediatric emergency department patients.
Topics: Adjuvants, Anesthesia; Adolescent; Anti-Anxiety Agents; Antiemetics; Central Nervous System Depressa | 2010 |
Treating primary headaches in the ED: can droperidol regain its role?
Topics: Adult; Analgesics; Basal Ganglia Diseases; Droperidol; Emergency Service, Hospital; Female; Headache | 2012 |