droperidol has been researched along with Arrhythmias, Cardiac in 35 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors determined whether increasing alpha 1-adrenergic blockade resulted in progressively less arrhythmic activity in the canine halothane-epinephrine arrhythmia model." | 7.67 | Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion. ( Gaba, DM; Hayward, E; Maze, M, 1985) |
| "The effects of diltiazem on ventricular arrhythmias and ventricular vulnerability for fibrillation, both in the very beginning of myocardial ischemia and in the early stage of myocardial necrosis, were evaluated in 13 mongrel dogs." | 7.67 | Antiarrhythmic and antifibrillatory action of diltiazem on early and late phase ventricular arrhythmias following coronary artery occlusion and on reperfusion ventricular arrhythmias. ( Bender, F; Gülker, H; Olbing, B; Rose, D; Thale, J, 1986) |
| "Scientific studies report that there is no basis to issue a black-box warning for perioperative administration of droperidol for postoperative nausea and vomiting on the basis of the potential of adverse cardiac events (prolongation of the QT interval and/or development of torsades de pointes)." | 4.86 | Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system. ( Barash, PG; Halloran, K, 2010) |
| " Although sevoflurane does not affect the transmural dispersion of repolarization and sevoflurane-induced QTc prolongation does not advance with time and by droperidol administration, QT interval prolongation and its associated arrhythmias should be carefully monitored during sevoflurane anesthesia in elderly patients." | 3.76 | Sevoflurane causes greater QTc interval prolongation in elderly patients than in younger patients. ( Hatano, K; Ikeda, S; Masuzawa, M; Nakao, S; Sakamoto, S; Shingu, K; Sumi, C, 2010) |
| "The statistically significant prolongation of QTc time after a sedative dose of droperidol is of concern because it may increase the risk for malignant cardiac arrhythmias." | 3.72 | Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. ( Berens, RJ; Cava, JR; Hoffman, GM; Stucke, AG; Stuth, EA, 2004) |
| "The authors determined whether increasing alpha 1-adrenergic blockade resulted in progressively less arrhythmic activity in the canine halothane-epinephrine arrhythmia model." | 3.67 | Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion. ( Gaba, DM; Hayward, E; Maze, M, 1985) |
| "The effects of diltiazem on ventricular arrhythmias and ventricular vulnerability for fibrillation, both in the very beginning of myocardial ischemia and in the early stage of myocardial necrosis, were evaluated in 13 mongrel dogs." | 3.67 | Antiarrhythmic and antifibrillatory action of diltiazem on early and late phase ventricular arrhythmias following coronary artery occlusion and on reperfusion ventricular arrhythmias. ( Bender, F; Gülker, H; Olbing, B; Rose, D; Thale, J, 1986) |
| "On the basis of an examination of 412 patients with myocardial infarction the efficacy of a long-term employment (for 3--4 days) of a neuroleptic Droperidol and a vasodilator Curantyl was examined." | 3.65 | [Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct]. ( Aleksandrova, LA; Avdiushko, BR; Gvatua, NA; Kravtsov, VL; Strokach, NT, 1976) |
| "In 109 patients, it was determined that halothane, when used to anesthetize patients for oral surgical procedures, causes an increased risk of serious cardiac arrhythmias when compared to methoxyflurane and fentanyl/droperidol." | 3.65 | Aberrant conduction as a precursor to cardiac arrhythmias during anesthesia for oral surgery. ( Gotta, AW; Kangwalklai, SR; Kozam, R; Pelkofski, J; Sullivan, CA, 1976) |
| "The authors report that, in treating approximately 12,000 patients over the past decade, they have never experienced a clinically significant adverse dysrhythmic event using droperidol to sedate severely agitated or violent patients." | 2.42 | A review of the safety and efficacy of droperidol for the rapid sedation of severely agitated and violent patients. ( Mastin, WD; Shale, CM; Shale, JH, 2003) |
| "Droperidol is a dopamine receptor antagonist that functions as an analgesic, sedative, and antiemetic." | 1.56 | Effectiveness and safety of droperidol in a United States emergency department. ( Bellolio, F; Cabrera, D; Gaw, CM; Jeffery, MM; Lohse, CM; Mattson, AE, 2020) |
| "Two cases of cardiac arrest about 30 min after intramuscular administration of premedication are analyzed." | 1.28 | [2 cases of brief asystole following premedication--a possible connection with Thalamonal?]. ( Ekhart, W; Hochwarter, J; Karausz, A; Spiegl, F, 1989) |
| "The incidence of cardiac dysrhythmia during inpatient dental anaesthesia with enflurane was studied following either hyoscine or droperidol as a supplement to papaveretum premedication." | 1.27 | The influence of premedication on the occurrence of dysrhythmias during oral surgery. ( O'Connell, P; Smith, DC, 1987) |
| "The incidence of cardiac dysrhythmias during inpatient dental anaesthesia under halothane was studied following either hyoscine or droperidol as a supplement to papaveretum for premedication." | 1.27 | Cardiac dysrhythmias during oral surgery. Comparison of hyoscine and droperidol premedication. ( O'Connell, P; Smith, DC, 1986) |
| "So-called epinephrine-induced arrhythmia with halothane anesthesia occurred in 1 of 34 instances with 1:300,000 solution and in 5 of 48 instances with 1:100,000 solution." | 1.26 | Hemodynamic effects of locally applied epinephrine used with various general anesthetic techniques. ( Funakoshi, Y; Iuchi, Y; Iwai, S; Kaneda, H, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (42.86) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Isbister, GK | 1 |
| Polanski, R | 1 |
| Cooper, JM | 1 |
| Keegan, M | 1 |
| Isoardi, KZ | 1 |
| Gaw, CM | 1 |
| Cabrera, D | 1 |
| Bellolio, F | 1 |
| Mattson, AE | 1 |
| Lohse, CM | 1 |
| Jeffery, MM | 1 |
| Patel, J | 1 |
| Nakao, S | 1 |
| Hatano, K | 1 |
| Sumi, C | 1 |
| Masuzawa, M | 1 |
| Sakamoto, S | 1 |
| Ikeda, S | 1 |
| Shingu, K | 1 |
| Halloran, K | 1 |
| Barash, PG | 1 |
| Miller, DR | 1 |
| Meyer, RJ | 1 |
| Habib, AS | 3 |
| Gan, TJ | 3 |
| Shale, JH | 1 |
| Shale, CM | 1 |
| Mastin, WD | 1 |
| Stuth, EA | 1 |
| Stucke, AG | 1 |
| Cava, JR | 1 |
| Hoffman, GM | 1 |
| Berens, RJ | 1 |
| Knott, JC | 1 |
| Taylor, DM | 1 |
| Castle, DJ | 1 |
| Sosis, MB | 1 |
| Prosser, RL | 1 |
| Jackson, CW | 1 |
| Sheehan, AH | 1 |
| Reddan, JG | 1 |
| Gómez-Arnau, J | 1 |
| Márquez-Montes, J | 1 |
| Avello, F | 1 |
| Young, D | 1 |
| Reisp, U | 1 |
| Funakoshi, Y | 1 |
| Iwai, S | 1 |
| Kaneda, H | 1 |
| Iuchi, Y | 1 |
| Petersen, EN | 1 |
| Gvatua, NA | 1 |
| Avdiushko, BR | 1 |
| Aleksandrova, LA | 1 |
| Strokach, NT | 1 |
| Kravtsov, VL | 1 |
| Whalley, DG | 1 |
| Tidnam, PF | 1 |
| Tyrrell, MF | 1 |
| Thompson, DS | 1 |
| Gotta, AW | 1 |
| Sullivan, CA | 1 |
| Pelkofski, J | 1 |
| Kangwalklai, SR | 1 |
| Kozam, R | 1 |
| Hochwarter, J | 1 |
| Spiegl, F | 1 |
| Karausz, A | 1 |
| Ekhart, W | 1 |
| Maze, M | 1 |
| Hayward, E | 1 |
| Gaba, DM | 1 |
| Smith, DC | 2 |
| O'Connell, P | 2 |
| Thale, J | 1 |
| Gülker, H | 1 |
| Olbing, B | 1 |
| Rose, D | 1 |
| Bender, F | 1 |
| Keith, L | 1 |
| Silver, A | 1 |
| Becker, M | 1 |
| Filias, N | 1 |
| Weisman, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oro-dispersible Olanzapine (Wafer) Versus Conventional Oral Haloperidol or Diazepam Tablets for the Management of Acute Agitation in the Accident and Emergency Department - a Multicentre Randomised Clinical Trial[NCT03246620] | Phase 4 | 12 participants (Actual) | Interventional | 2017-09-01 | Terminated (stopped due to The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias.) | ||
| Intramuscular Olanzapine Versus Haloperidol or Midazolam for the Management of Acute Agitation in the Emergency Department - a Multicentre Randomised Clinical Trial[NCT02380118] | Phase 4 | 167 participants (Actual) | Interventional | 2014-12-31 | Terminated (stopped due to Primary endpoint reached based on data projection from interim analysis.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for droperidol and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Droperidol- and ondansetron-induced life-threatening arrhythmias.
Topics: Aged; Antiemetics; Arrhythmias, Cardiac; Droperidol; Fatal Outcome; Female; Humans; Long QT Syndrome | 2013 |
Inside the black box: current policies and concerns with the United States Food and Drug Administration's highest drug safety warning system.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Arrhythmias, Cardiac; Consumer Product Safety; | 2010 |
A review of the safety and efficacy of droperidol for the rapid sedation of severely agitated and violent patients.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agents; Arrhythmias, | 2003 |
1 trial available for droperidol and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R | 2006 |
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R | 2006 |
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R | 2006 |
Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department.
Topics: Adolescent; Adult; Aged; Apnea; Arrhythmias, Cardiac; Cardiovascular Physiological Phenomena; Dose-R | 2006 |
31 other studies available for droperidol and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications.
Topics: Acetaminophen; Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coma; Diazepam; Droperidol; Drug | 2022 |
Effectiveness and safety of droperidol in a United States emergency department.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Analgesics, Opioid; Antiemetics; Arrhythmias, Cardiac; Dro | 2020 |
Sevoflurane causes greater QTc interval prolongation in elderly patients than in younger patients.
Topics: Adult; Age Factors; Aged; Anesthetics, Inhalation; Antiemetics; Arrhythmias, Cardiac; Droperidol; El | 2010 |
Arrhythmogenic potential of antiemetics: perspectives on risk-benefits.
Topics: Antiemetics; Arrhythmias, Cardiac; Atrial Fibrillation; Droperidol; Electrocardiography; Humans; Ind | 2003 |
FDA "black box" labeling.
Topics: Adverse Drug Reaction Reporting Systems; Antiemetics; Antipsychotic Agents; Arrhythmias, Cardiac; Dr | 2003 |
Food and drug administration black box warning on the perioperative use of droperidol: a review of the cases.
Topics: Adult; Aged; Antiemetics; Arrhythmias, Cardiac; Databases, Factual; Droperidol; Drug Labeling; Femal | 2003 |
There should be a threshold dose for the FDA black-box warning on droperidol.
Topics: Adjuvants, Anesthesia; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Droperidol; United St | 2003 |
Safety of patients reason for FDA black box warning on droperidol.
Topics: Antiemetics; Arrhythmias, Cardiac; Droperidol; Torsades de Pointes; United States; United States Foo | 2004 |
Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia.
Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Dr | 2004 |
Droperidol has been reported to cause serious arrhythmias.
Topics: Antiemetics; Arrhythmias, Cardiac; Droperidol; Humans; Long QT Syndrome | 2006 |
Droperidol use in the emergency department is not safe.
Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Droperidol; Drug Monitoring; Electrocardiography; Emerge | 2006 |
Evidence-based review of the black-box warning for droperidol.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agents; Arrhythmias, Cardiac; Da | 2007 |
Fentanyl and droperidol effects on the refractoriness of the accessory pathway in the Wolff-Parkinson-White syndrome.
Topics: Anesthesia, Intravenous; Arrhythmias, Cardiac; Droperidol; Electrophysiology; Female; Fentanyl; Hear | 1983 |
Inapsine. Weighing the risk of fatal arrhythmias.
Topics: Antiemetics; Arrhythmias, Cardiac; Death, Sudden; Droperidol; Humans; Risk Assessment | 2002 |
Black-box warning for droperidol surprises pharmacists.
Topics: Antiemetics; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Droperidol; Drug Labeling; Formularies, H | 2002 |
Arrhythmias from droperidol?
Topics: Adjuvants, Anesthesia; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Droperidol; Drug Appr | 2002 |
[Oral treatment of heart rhythm disorders with dehydrobenzperidol].
Topics: Administration, Oral; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Droperidol; Female; Humans | 1975 |
Hemodynamic effects of locally applied epinephrine used with various general anesthetic techniques.
Topics: Alcuronium; Analysis of Variance; Anesthesia, General; Anesthetics; Arrhythmias, Cardiac; Atropine; | 1977 |
Experimental anti-arrhythmic properties of melperone, a neuroleptic butyrophenone.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Butyrophenones; Droperidol; Epinep | 1978 |
[Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Dipyridamole; Drop | 1976 |
A comparison of the incidence of cardiac arrhythmia during two methods of anaesthesia for dental extractions.
Topics: Adolescent; Adult; Anesthesia, Dental; Arrhythmias, Cardiac; Droperidol; Female; Halothane; Heart Ra | 1976 |
Aberrant conduction as a precursor to cardiac arrhythmias during anesthesia for oral surgery.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, General; Arrhythmias, Cardiac; Child; Child | 1976 |
[2 cases of brief asystole following premedication--a possible connection with Thalamonal?].
Topics: Adult; Analgesics; Arrhythmias, Cardiac; Atropine; Droperidol; Drug Combinations; Fentanyl; Heart Ar | 1989 |
Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion.
Topics: Adrenergic alpha-Antagonists; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Dogs; Dose-Resp | 1985 |
The influence of premedication on the occurrence of dysrhythmias during oral surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Dental; Anesthesia, General; Arrhythmias, Ca | 1987 |
Antiarrhythmic and antifibrillatory action of diltiazem on early and late phase ventricular arrhythmias following coronary artery occlusion and on reperfusion ventricular arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Blood Pressure; Coronary Diseas | 1986 |
Cardiac dysrhythmias during oral surgery. Comparison of hyoscine and droperidol premedication.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Arrhythmias, Cardiac; Droperidol; Feasibility Studies; | 1986 |
Anesthesia for laparoscopy.
Topics: Alphaprodine; Anesthesia; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Local; Anesthetics; | 1974 |
[Some suggestions for the treatment of myocardial infarct in the pre-hospitalization phase].
Topics: Allied Health Personnel; Ambulances; Angina Pectoris; Arrhythmias, Cardiac; Atropine; Droperidol; He | 1973 |
Anesthesia for pediatric ophthalmology.
Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Dissociative; Arrhythmias, Cardiac; Barbit | 1971 |