droperidol has been researched along with Acute Disease in 49 studies
Droperidol: A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
droperidol : An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
Acute Disease: Disease having a short and relatively severe course.
Excerpt | Relevance | Reference |
---|---|---|
"We report a case of bilateral ocular deviation due to droperidol-induced acute dystonia that was initially undiagnosed." | 7.76 | [Case of acute dystonia during epidural droperidol infusion to prevent postoperative nausea and vomiting]. ( Oe, K; Serada, K; Suzuki, T; Yamada, S, 2010) |
"When droperidol was compared with placebo, for the outcome of tranquillisation or asleep by 30 minutes we found evidence of a clear difference (1 RCT, N = 227, RR 1." | 6.53 | Droperidol for psychosis-induced aggression or agitation. ( Khokhar, MA; Rathbone, J, 2016) |
"A patient developed acute dystonia following intravenous administration of metocroplamide 20 mg." | 5.42 | [Metoclopramide Induced Acute Dystonia during Intravenous Patient-controlled Analgesia with Droperidol]. ( Iwade, M; Kamata, K; Morioka, N; Nakashima, K; Ozaki, M; Takahashi, E, 2015) |
"We report a case of bilateral ocular deviation due to droperidol-induced acute dystonia that was initially undiagnosed." | 3.76 | [Case of acute dystonia during epidural droperidol infusion to prevent postoperative nausea and vomiting]. ( Oe, K; Serada, K; Suzuki, T; Yamada, S, 2010) |
" Eight days later, he presented with a neuroleptic malignant syndrome following an injection of droperidol." | 3.70 | Malignant hyperthermia and neuroleptic malignant syndrome in a patient during treatment for acute asthma. ( Cardinaud, JP; Favier, JC; Gbikpi-Benissan, G; Gruson, D; Hilbert, G; Portel, L, 1999) |
"On the basis of an examination of 412 patients with myocardial infarction the efficacy of a long-term employment (for 3--4 days) of a neuroleptic Droperidol and a vasodilator Curantyl was examined." | 3.65 | [Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct]. ( Aleksandrova, LA; Avdiushko, BR; Gvatua, NA; Kravtsov, VL; Strokach, NT, 1976) |
"Ketamine has been shown to have a morphine-sparing effect soon after surgery." | 2.74 | The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. ( Baud, A; Couvret, C; Favard, L; Fusciardi, J; Laffon, M; Le Tendre, C; Pourrat, X; Remérand, F, 2009) |
"The treatment of a migraine attack can be difficult when first-line medication is unsuccessful and options for parenteral "rescue" therapy are limited." | 2.71 | Acute migraine treatment with droperidol: A randomized, double-blind, placebo-controlled trial. ( Alam, AS; Mendizabal, JE; Rothrock, JF; Silberstein, SD; Young, WB, 2003) |
"When droperidol was compared with placebo, for the outcome of tranquillisation or asleep by 30 minutes we found evidence of a clear difference (1 RCT, N = 227, RR 1." | 2.53 | Droperidol for psychosis-induced aggression or agitation. ( Khokhar, MA; Rathbone, J, 2016) |
"Droperidol was better than placebo and at least as effective as comparator drugs such as prochlorperazine, meperidine, or olanzapine using droperidol doses of 2." | 2.52 | Droperidol for the treatment of acute migraine headaches. ( Musselman, ME; Shewmaker, J; Thomas, MC, 2015) |
"Droperidol was compared with benzodiazepines, antipsychotics and combination treatment." | 2.49 | [Droperidol for the treatment of acutely agitated patients: still an option]. ( Budiharto, L; De Fruyt, J, 2013) |
"A patient developed acute dystonia following intravenous administration of metocroplamide 20 mg." | 1.42 | [Metoclopramide Induced Acute Dystonia during Intravenous Patient-controlled Analgesia with Droperidol]. ( Iwade, M; Kamata, K; Morioka, N; Nakashima, K; Ozaki, M; Takahashi, E, 2015) |
"It is a promising therapy for migraine." | 1.30 | Droperidol for acute migraine headache. ( Allegra, J; Eskin, B; Irving, C; Nashed, AH; Ostrow, A; Reischel, U; Richman, PB; Ritter, A; Szucs, P, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 22 (44.90) | 18.7374 |
1990's | 6 (12.24) | 18.2507 |
2000's | 10 (20.41) | 29.6817 |
2010's | 11 (22.45) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Budiharto, L | 1 |
De Fruyt, J | 1 |
Gupta, S | 1 |
Oosthuizen, R | 1 |
Pulfrey, S | 1 |
Saguil, A | 1 |
Lax, JW | 1 |
Thomas, MC | 1 |
Musselman, ME | 1 |
Shewmaker, J | 1 |
Kamata, K | 1 |
Takahashi, E | 1 |
Morioka, N | 1 |
Nakashima, K | 1 |
Iwade, M | 1 |
Ozaki, M | 1 |
Taylor, DM | 3 |
Yap, CYL | 2 |
Knott, JC | 3 |
Taylor, SE | 2 |
Phillips, GA | 3 |
Karro, J | 2 |
Chan, EW | 3 |
Kong, DCM | 2 |
Castle, DJ | 3 |
Khokhar, MA | 1 |
Rathbone, J | 2 |
Remérand, F | 1 |
Le Tendre, C | 1 |
Baud, A | 1 |
Couvret, C | 1 |
Pourrat, X | 1 |
Favard, L | 1 |
Laffon, M | 1 |
Fusciardi, J | 1 |
Yamada, S | 1 |
Suzuki, T | 1 |
Oe, K | 1 |
Serada, K | 1 |
Isbister, GK | 1 |
Calver, LA | 1 |
Page, CB | 1 |
Stokes, B | 1 |
Bryant, JL | 1 |
Downes, MA | 1 |
Kong, DC | 1 |
Park, CK | 1 |
Choi, HY | 1 |
Oh, IY | 1 |
Kim, MS | 1 |
Silberstein, SD | 1 |
Young, WB | 1 |
Mendizabal, JE | 1 |
Rothrock, JF | 2 |
Alam, AS | 1 |
Ehrenberg, BL | 1 |
Weaver, CS | 1 |
Jones, JB | 1 |
Chisholm, CD | 1 |
Foley, MJ | 1 |
Giles, BK | 1 |
Somerville, GG | 1 |
Brizendine, EJ | 1 |
Cordell, WH | 1 |
Cure, S | 2 |
Carpenter, S | 2 |
Kaneko, T | 1 |
Maekawa, T | 1 |
Ting, JY | 1 |
Barnes, TR | 1 |
Braude, WM | 1 |
Hill, DJ | 1 |
Sherman, DM | 1 |
Pavlovskii, MP | 1 |
Kolomiĭtsev, VI | 1 |
Dolenko, VKh | 1 |
Resnick, M | 1 |
Burton, BT | 1 |
Portel, L | 1 |
Hilbert, G | 1 |
Gruson, D | 1 |
Favier, JC | 1 |
Gbikpi-Benissan, G | 1 |
Cardinaud, JP | 1 |
Irving, C | 2 |
Richman, PB | 2 |
Kaiafas, C | 1 |
Eskin, B | 2 |
Ritter, A | 2 |
Allegra, J | 2 |
Reischel, U | 1 |
Ostrow, A | 1 |
Szucs, P | 1 |
Nashed, AH | 1 |
Chambers, RA | 1 |
Druss, BG | 1 |
McAllister-Williams, RH | 1 |
Ferrier, IN | 1 |
Korobko, SF | 1 |
Markovskaia, MD | 1 |
Slepian, IuIa | 1 |
van Leeuwen, AM | 1 |
Molders, J | 1 |
Sterkmans, P | 1 |
Mielants, P | 1 |
Martens, C | 1 |
Toussaint, C | 1 |
Hovent, AM | 1 |
Desseilles, MF | 1 |
Koch, H | 1 |
Devroye, A | 1 |
Parent, M | 1 |
Komarov, FI | 1 |
Ol'binskaia, LI | 1 |
Enikeeva, NB | 1 |
Ovasapian, IuA | 1 |
Popnikolov, S | 1 |
Johnson, WH | 1 |
Fenton, RS | 1 |
Evans, A | 1 |
Kovách, G | 1 |
Gvatua, NA | 1 |
Avdiushko, BR | 1 |
Aleksandrova, LA | 1 |
Strokach, NT | 1 |
Kravtsov, VL | 3 |
Patton, CM | 1 |
Weiser, G | 1 |
Tahedl, A | 1 |
Reisecker, F | 1 |
Meyer, H | 1 |
Szuba, MP | 1 |
Bergman, KS | 1 |
Baxter, LR | 1 |
Guze, BH | 1 |
Reynolds, CA | 1 |
Pelletier, LR | 1 |
Melnick, BM | 1 |
Hooper, JF | 1 |
Prusiński, A | 1 |
Rózniecki, J | 1 |
Durko, A | 1 |
Głuszcz-Zielińska, A | 1 |
Kozubski, W | 1 |
Swatko, A | 1 |
Davydova, NT | 1 |
Zminkowska, U | 1 |
Woyda, J | 1 |
Luczak, J | 1 |
Szulc, EJ | 1 |
Kishenets, VA | 1 |
Lytkin, MI | 1 |
Melekhov, PA | 1 |
Tomashevskiĭ, AA | 1 |
Krasil'nikov, AV | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Oro-dispersible Olanzapine (Wafer) Versus Conventional Oral Haloperidol or Diazepam Tablets for the Management of Acute Agitation in the Accident and Emergency Department - a Multicentre Randomised Clinical Trial[NCT03246620] | Phase 4 | 12 participants (Actual) | Interventional | 2017-09-01 | Terminated (stopped due to The study was terminated prematurely due to difficulties in patient recruitment and associated potential for selection bias.) | ||
Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients[NCT02160301] | Phase 4 | 0 participants (Actual) | Interventional | 2017-11-30 | Withdrawn (stopped due to Insufficient infrastructure/funding for enrollment) | ||
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
Intramuscular Olanzapine Versus Haloperidol or Midazolam for the Management of Acute Agitation in the Emergency Department - a Multicentre Randomised Clinical Trial[NCT02380118] | Phase 4 | 167 participants (Actual) | Interventional | 2014-12-31 | Terminated (stopped due to Primary endpoint reached based on data projection from interim analysis.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
9 reviews available for droperidol and Acute Disease
Article | Year |
---|---|
[Droperidol for the treatment of acutely agitated patients: still an option].
Topics: Acute Disease; Antipsychotic Agents; Droperidol; Humans; Psychotic Disorders; Randomized Controlled | 2013 |
Acute migraine treatment in emergency settings.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Dexamethasone; | 2014 |
Droperidol for the treatment of acute migraine headaches.
Topics: Acute Disease; Dopamine Antagonists; Droperidol; Humans; Migraine Disorders; Randomized Controlled T | 2015 |
Droperidol for psychosis-induced aggression or agitation.
Topics: Acute Disease; Aggression; Antipsychotic Agents; Benzodiazepines; Droperidol; Haloperidol; Humans; M | 2016 |
Droperidol for acute psychosis.
Topics: Acute Disease; Antipsychotic Agents; Droperidol; Humans; Psychotic Disorders; Randomized Controlled | 2004 |
[Clinical application of brain hypothermia therapy for acute brain insults].
Topics: Acute Disease; Brain Injuries; Cardiopulmonary Resuscitation; Critical Care; Droperidol; Evidence-Ba | 2007 |
Droperidol: efficacy and side effects in psychiatric emergencies.
Topics: Acute Disease; Animals; Antipsychotic Agents; Clinical Trials as Topic; Crisis Intervention; Dangero | 1999 |
Droperidol for acute psychosis.
Topics: Acute Disease; Antipsychotic Agents; Droperidol; Humans; Psychotic Disorders; Randomized Controlled | 2001 |
Rapid tranquillisation: time for a reappraisal of options for parenteral therapy.
Topics: Acute Disease; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Clopenthixol; Death, Sudd | 2002 |
11 trials available for droperidol and Acute Disease
Article | Year |
---|---|
Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical Trial.
Topics: Acute Disease; Adult; Benzodiazepines; Conscious Sedation; Double-Blind Method; Droperidol; Drug The | 2017 |
Intravenous midazolam-droperidol combination, droperidol or olanzapine monotherapy for methamphetamine-related acute agitation: subgroup analysis of a randomized controlled trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Australia; Benzodiazepines; Dopamin | 2017 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.
Topics: Acetaminophen; Acute Disease; Adult; Aged; Analgesia; Analgesia, Patient-Controlled; Analgesics; Ana | 2009 |
Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study.
Topics: Acute Disease; Adult; Aggression; Double-Blind Method; Droperidol; Drug Therapy, Combination; Emerge | 2010 |
Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Droperidol; Drug Thera | 2013 |
Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Droperidol; Drug Thera | 2013 |
Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Droperidol; Drug Thera | 2013 |
Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Droperidol; Drug Thera | 2013 |
Acute migraine treatment with droperidol: A randomized, double-blind, placebo-controlled trial.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Anxiety; Dopamine Antagonists; Dose-Response Relation | 2003 |
Droperidol vs prochlorperazine for the treatment of acute headache.
Topics: Acute Disease; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antiemetics; Dopamine Antagonists; | 2004 |
Droperidol vs. haloperidol in the initial management of acutely agitated patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Clinical Trials as Topic; Commitment of Mentally Ill; Danger | 1984 |
Droperidol in acutely agitated patients. A double-blind placebo-controlled study.
Topics: Acute Disease; Adolescent; Adult; Aged; Bipolar Disorder; Clinical Trials as Topic; Droperidol; Drug | 1977 |
[Treatment of hypertensive crises with droperidol].
Topics: Acute Disease; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Droperidol; Drug Evaluation; F | 1978 |
Effects of droperidol in management of vestibular disorders.
Topics: Acute Disease; Clinical Trials as Topic; Droperidol; Electronystagmography; Fentanyl; Humans; Labyri | 1976 |
29 other studies available for droperidol and Acute Disease
Article | Year |
---|---|
Treatment of acute migraine in the emergency department.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents | 2014 |
[Metoclopramide Induced Acute Dystonia during Intravenous Patient-controlled Analgesia with Droperidol].
Topics: Acute Disease; Adult; Analgesia, Patient-Controlled; Antiemetics; Droperidol; Dystonia; Female; Huma | 2015 |
[Case of acute dystonia during epidural droperidol infusion to prevent postoperative nausea and vomiting].
Topics: Acute Disease; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics | 2010 |
Acute dystonia by droperidol during intravenous patient-controlled analgesia in young patients.
Topics: Acute Disease; Adolescent; Analgesia, Patient-Controlled; Analgesics; Droperidol; Dystonia; Humans; | 2002 |
Acute migraine treatment with droperidol.
Topics: Acute Disease; Adult; Age of Onset; Akathisia, Drug-Induced; Chronic Disease; Diagnosis, Differentia | 2003 |
Reversible cardiomyopathy associated with acute inhaled marijuana use in a young adult.
Topics: Acute Disease; Adult; Antipsychotic Agents; Blood Pressure; Cannabinoids; Cannabis; Cardiomyopathies | 2007 |
Acute akathisia after oral droperidol and metoclopramide preoperative medication.
Topics: Acute Disease; Akathisia, Drug-Induced; Droperidol; Eye Diseases; Female; Humans; Male; Metocloprami | 1982 |
[Indications for the use of vasoactive preparations in acute blood loss].
Topics: Acute Disease; Animals; Blood Transfusion, Autologous; Bloodletting; Combined Modality Therapy; Dext | 1984 |
Treatment of acute migraine with intravenous droperidol.
Topics: Acute Disease; Child; Droperidol; Female; Humans; Migraine Disorders | 1997 |
Malignant hyperthermia and neuroleptic malignant syndrome in a patient during treatment for acute asthma.
Topics: Acute Disease; Adjuvants, Anesthesia; Adult; Anesthetics, Inhalation; Asthma; Bronchodilator Agents; | 1999 |
Droperidol for the treatment of acute peripheral vertigo.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antiemetics; Droperidol; Emergency Treatment; Female; | 1999 |
Droperidol for acute migraine headache.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Analgesics; Dopamine Antagonists; Droperidol; Female; | 1999 |
[Experience with the management of labor in severe forms of late toxicosis].
Topics: Acute Disease; Adult; Droperidol; Female; Humans; Labor Stage, First; Obstetric Labor Complications; | 1976 |
[Treatment of cardiac insufficiency in the acute stage of cardiac infarct].
Topics: Acute Disease; Blood Pressure; Droperidol; Drug Therapy, Combination; Furosemide; Hemodynamics; Huma | 1979 |
The effect of droperidol in hypertensive crises.
Topics: Acute Disease; Adult; Aged; Droperidol; Female; Humans; Hypertension; Injections, Intravenous; Male; | 1977 |
[Experience with combined use of neurolepsy and vasodilator substances in the treatment of patients with acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Dipyridamole; Drop | 1976 |
Rapid induction of acute dyskinesia by droperidol.
Topics: Acute Disease; Adult; Anesthesia, Intravenous; Droperidol; Humans; Male; Movement Disorders | 1975 |
[Advantages of the initial therapy of acute schizophrenia with large doses of droperidol/A comparative study (author's transl)].
Topics: Acute Disease; Biperiden; Blood Pressure; Clopenthixol; Clozapine; Droperidol; Drug Administration S | 1975 |
Safety and efficacy of high-dose droperidol in agitated patients.
Topics: Acute Disease; Adult; Dose-Response Relationship, Drug; Droperidol; Female; Humans; Infusions, Intra | 1992 |
Extrapyramidal reactions to low-dose droperidol.
Topics: Acute Disease; Adult; Basal Ganglia Diseases; Dose-Response Relationship, Drug; Droperidol; Female; | 1988 |
Droperidol and acute psychosis.
Topics: Acute Disease; Droperidol; Haloperidol; Humans; Psychotic Disorders | 1987 |
[Acute dystonic reactions after administration of neuroleptics and other drugs].
Topics: Acute Disease; Adult; Child; Droperidol; Dystonia; Female; Humans; Male; Metoclopramide; Middle Aged | 1985 |
[Effect of droperidol on the state of the peripheral circulation in the acute period of myocardial infarct].
Topics: Acute Disease; Aged; Blood Circulation; Droperidol; Hemodynamics; Humans; Middle Aged; Myocardial In | 1974 |
[Value of neuroleptoanalgesia II in the treatment of pain during myocardial infarct].
Topics: Acute Disease; Adult; Aged; Droperidol; Female; Fentanyl; Humans; Male; Middle Aged; Myocardial Infa | 1974 |
[Clinical evaluation of fentanyl and dehydrobenzperidol in acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Benperidol; Butyrophenones; Droperidol; Evaluation Studies as Topic; Fem | 1972 |
[Effect of dehydrobenzperidol on the hemodynamics in myocardial infarct].
Topics: Acute Disease; Droperidol; Hemodynamics; Humans; Injections, Intravenous; Myocardial Infarction | 1973 |
[Clinical evaluation of agents used in type II neuroleptoanalgesia (NLA II) in acute myocardial infarct].
Topics: Acute Disease; Adult; Aged; Droperidol; Drug Synergism; Female; Fentanyl; Humans; Male; Middle Aged; | 1973 |
[Effect of droperidol on the central hemodynamics and the functional state of the kidneys in myocardial infarct].
Topics: Acid-Base Equilibrium; Acute Disease; Adult; Aged; Blood Pressure Determination; Cardiac Output; Car | 1974 |
[Neuroleptoanalgesia in combination with local infiltration anesthesia in operations for acute appendicitis].
Topics: Acute Disease; Analgesics; Anesthesia, Local; Anesthetics, Local; Appendectomy; Appendicitis; Droper | 1974 |