drimenol has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for drimenol and Neoplasms
Article | Year |
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Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines.
Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. Topics: Cell Line, Tumor; Cell Membrane Permeability; Furans; HT29 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Mitochondrial Membranes; Neoplasms; Polycyclic Sesquiterpenes; Sesquiterpenes; Terpenes; Tetrahydronaphthalenes | 2014 |