drimenol and Neoplasms

drimenol has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for drimenol and Neoplasms

Article	Year
Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines. Molecules (Basel, Switzerland), 2014, Nov-18, Volume: 19, Issue:11 Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. Topics: Cell Line, Tumor; Cell Membrane Permeability; Furans; HT29 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Mitochondrial Membranes; Neoplasms; Polycyclic Sesquiterpenes; Sesquiterpenes; Terpenes; Tetrahydronaphthalenes	2014

Article

Year

Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines.

Molecules (Basel, Switzerland), 2014, Nov-18, Volume: 19, Issue:11

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

Topics: Cell Line, Tumor; Cell Membrane Permeability; Furans; HT29 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Mitochondrial Membranes; Neoplasms; Polycyclic Sesquiterpenes; Sesquiterpenes; Terpenes; Tetrahydronaphthalenes

2014