drimane and Colonic-Neoplasms

drimane has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for drimane and Colonic-Neoplasms

ArticleYear
Cytotoxic activity of rearranged drimane meroterpenoids against colon cancer cells via down-regulation of β-catenin expression.
    Journal of natural products, 2015, Mar-27, Volume: 78, Issue:3

    Colorectal cancer has emerged as a major cause of death in Western countries. Down-regulation of β-catenin expression has been considered a promising approach for cytotoxic drug formulation. Eight 4,9-friedodrimane-type sesquiterpenoids (1-8) were acquired using the oxidative potential of Verongula rigida on bioactive metabolites from two Smenospongia sponges. Compounds 3 and 4 contain a 2,2-dimethylbenzo[d]oxazol-6(2H)-one moiety as their substituted heterocyclic residues, which is unprecedented in such types of meroterpenoids. Gauge-invariant atomic orbital NMR chemical shift calculations were employed to investigate stereochemical details with support of the application of advanced statistics such as CP3 and DP4. Compounds 2 and 8 and the mixture of 3 and 4 suppressed β-catenin response transcription (CRT) via degrading β-catenin and exhibited cytotoxic activity on colon cancer cells, implying that their anti-CRT potential is, at least in part, one of their underlying antineoplastic mechanisms.

    Topics: Antineoplastic Agents; beta Catenin; Colonic Neoplasms; Down-Regulation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Polycyclic Sesquiterpenes; Sesquiterpenes; Terpenes

2015