dpa-713 and Glioblastoma

dpa-713 has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for dpa-713 and Glioblastoma

Article	Year
First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO). Journal of medicinal chemistry, 2015, Nov-12, Volume: 58, Issue:21 We show that changing the number and position of nitrogen atoms in the heteroatomic core of a pyrazolopyrimidine acetamide is sufficient to induce complex binding to wild type human TSPO. Only compounds with this complex binding profile lacked intrinsic effect on glioblastoma proliferation but positively modulated the antiproliferative effects of a synthetic TSPO ligand. To the best of our knowledge this is the first demonstration of allosteric-like interaction at the wild type human TSPO. Topics: Acetamides; Allosteric Regulation; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Protein Binding; Pyrimidines; Receptors, GABA	2015

Article

Year

First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO).

Journal of medicinal chemistry, 2015, Nov-12, Volume: 58, Issue:21

We show that changing the number and position of nitrogen atoms in the heteroatomic core of a pyrazolopyrimidine acetamide is sufficient to induce complex binding to wild type human TSPO. Only compounds with this complex binding profile lacked intrinsic effect on glioblastoma proliferation but positively modulated the antiproliferative effects of a synthetic TSPO ligand. To the best of our knowledge this is the first demonstration of allosteric-like interaction at the wild type human TSPO.

Topics: Acetamides; Allosteric Regulation; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Protein Binding; Pyrimidines; Receptors, GABA

2015