Page last updated: 2024-10-26

doxylamine and Rhabdomyolysis

doxylamine has been researched along with Rhabdomyolysis in 12 studies

Doxylamine: Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.

Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.

Research Excerpts

ExcerptRelevanceReference
"9% saline (NS) in the treatment of rhabdomyolysis induced by doxylamine intoxication."9.12Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication. ( Cho, YS; Kim, SH; Lim, H, 2007)
"The aim of this study was to investigate the associative factors of rhabdomyolysis in patients with doxylamine overdose who had normal creatine phosphokinase levels at admission."7.77The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose. ( Jeong, SH; Jeong, WJ; Kim, HJ; Kim, JH; Kim, SH; Oh, SH; Park, KN; Wee, JH; Youn, CS, 2011)
"The objective of this prospective study was to identify risk factors for developing rhabdomyolysis in patients with doxylamine overdose."7.74Risk factors for rhabdomyolysis following doxylamine overdose. ( Jo, YI; Koh, SY; Lee, JH; Lee, SM; Park, JH; Seo, TH; Song, JO, 2007)
"Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines."7.68Severe rhabdomyolysis after doxylamine overdose. ( Miller, CH; Ognibere, AJ; Soto, LF, 1993)
"Rhabdomyolysis and secondary acute renal failure are rare but potentially serious complications, making early recognition and treatment essential."5.31Doxylamine overdose as a potential cause of rhabdomyolysis. ( Fasseas, P; Leybishkis, B; Ryan, KF, 2001)
"The aim of this study was to investigate the associative factors of rhabdomyolysis in patients with doxylamine overdose who had normal creatine phosphokinase levels at admission."3.77The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose. ( Jeong, SH; Jeong, WJ; Kim, HJ; Kim, JH; Kim, SH; Oh, SH; Park, KN; Wee, JH; Youn, CS, 2011)
"The objective of this prospective study was to identify risk factors for developing rhabdomyolysis in patients with doxylamine overdose."3.74Risk factors for rhabdomyolysis following doxylamine overdose. ( Jo, YI; Koh, SY; Lee, JH; Lee, SM; Park, JH; Seo, TH; Song, JO, 2007)
"Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines."3.68Severe rhabdomyolysis after doxylamine overdose. ( Miller, CH; Ognibere, AJ; Soto, LF, 1993)
" We report a case of a suicide attempt in a young adult male where ingestion of the antihistamines diphenhydramine and doxylamine was complicated by non-traumatic rhabdomyolysis and acute renal failure."3.68Non-traumatic rhabdomyolysis complicating antihistamine overdose. ( Dolgin, J; Frankel, D; Murray, BM, 1993)
"Rhabdomyolysis and secondary acute renal failure are rare but potentially serious complications, making early recognition and treatment essential."1.31Doxylamine overdose as a potential cause of rhabdomyolysis. ( Fasseas, P; Leybishkis, B; Ryan, KF, 2001)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's3 (25.00)18.2507
2000's4 (33.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, E1
Choi, YH1
Lim, JY1
Lee, J1
Lee, DH1
Kim, HJ1
Oh, SH1
Youn, CS1
Wee, JH1
Kim, JH1
Jeong, WJ1
Kim, SH2
Jeong, SH1
Park, KN1
Khosla, U1
Ruel, KS1
Hunt, DP1
Cho, YS1
Lim, H1
Jo, YI1
Song, JO1
Park, JH1
Koh, SY1
Lee, SM1
Seo, TH1
Lee, JH1
Soto, LF1
Miller, CH1
Ognibere, AJ1
Frankel, D1
Dolgin, J1
Murray, BM1
Paytubí Garí, C1
Ballús, J1
Marruecos, L1
Leybishkis, B1
Fasseas, P1
Ryan, KF1
Köppel, C2
Ibe, K2
Oberdisse, U1
Mendoza, FS1
Atiba, JO1
Krensky, AM1
Scannell, LM1
Tenczer, J1

Reviews

1 review available for doxylamine and Rhabdomyolysis

ArticleYear
[Nontraumatic rhabdomyolysis due to oral poisoning by doxylamine succinate].
    Medicina clinica, 1997, Mar-08, Volume: 108, Issue:9

    Topics: Acute Disease; Adult; Doxylamine; Histamine H1 Antagonists; Humans; Male; Poisoning; Rhabdomyolysis;

1997

Trials

2 trials available for doxylamine and Rhabdomyolysis

ArticleYear
The effect of early urine alkalinization on occurrence rhabdomyolysis and hospital stay in high dose doxylamine ingestion.
    The American journal of emergency medicine, 2018, Volume: 36, Issue:7

    Topics: Adult; Antidotes; Buffers; Charcoal; Doxylamine; Drug Overdose; Drug Therapy, Combination; Female; F

2018
Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication.
    Emergency medicine journal : EMJ, 2007, Volume: 24, Issue:4

    Topics: Adult; Doxylamine; Female; Fluid Therapy; Histamine H1 Antagonists; Humans; Isotonic Solutions; Male

2007

Other Studies

9 other studies available for doxylamine and Rhabdomyolysis

ArticleYear
The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:8

    Topics: Adult; Antiemetics; Chi-Square Distribution; Creatine Kinase; Doxylamine; Drug Overdose; Female; Hea

2011
Antihistamine-induced rhabdomyolysis.
    Southern medical journal, 2003, Volume: 96, Issue:10

    Topics: Adult; Diphenhydramine; Doxylamine; Drug Overdose; Histamine H1 Antagonists; Humans; Male; Rhabdomyo

2003
Risk factors for rhabdomyolysis following doxylamine overdose.
    Human & experimental toxicology, 2007, Volume: 26, Issue:8

    Topics: Acute Kidney Injury; Adult; Creatinine; Dose-Response Relationship, Drug; Doxylamine; Drug Overdose;

2007
Severe rhabdomyolysis after doxylamine overdose.
    Postgraduate medicine, 1993, Volume: 93, Issue:8

    Topics: Adult; Bicarbonates; Creatine Kinase; Doxylamine; Drug Overdose; Epilepsy, Tonic-Clonic; Histamine H

1993
Non-traumatic rhabdomyolysis complicating antihistamine overdose.
    Journal of toxicology. Clinical toxicology, 1993, Volume: 31, Issue:3

    Topics: Acute Kidney Injury; Adult; Blood Urea Nitrogen; Creatinine; Diphenhydramine; Doxylamine; Drug Overd

1993
Doxylamine overdose as a potential cause of rhabdomyolysis.
    The American journal of the medical sciences, 2001, Volume: 322, Issue:1

    Topics: Acute Kidney Injury; Adult; Doxylamine; Drug Overdose; Histamine H1 Antagonists; Humans; Male; Nonpr

2001
Rhabdomyolysis in doxylamine overdose.
    Lancet (London, England), 1987, Feb-21, Volume: 1, Issue:8530

    Topics: Adolescent; Adult; Doxylamine; Female; Humans; Male; Pyridines; Rhabdomyolysis; Suicide, Attempted

1987
Rhabdomyolysis complicating doxylamine overdose.
    Clinical pediatrics, 1987, Volume: 26, Issue:11

    Topics: Adolescent; Creatine Kinase; Doxylamine; Humans; Male; Pyridines; Rhabdomyolysis

1987
Poisoning with over-the-counter doxylamine preparations: an evaluation of 109 cases.
    Human toxicology, 1987, Volume: 6, Issue:5

    Topics: Adolescent; Adult; Doxylamine; Gastric Lavage; Humans; Middle Aged; Nonprescription Drugs; Pyridines

1987