doxylamine has been researched along with Pregnancy in 186 studies
Doxylamine: Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in PARKINSONISM.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxylamine-pyridoxine is recommended as a first line treatment for nausea and vomiting during pregnancy and it is commonly prescribed." | 9.27 | Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. ( El-Emam, K; Meaney, C; Moineddin, R; Persaud, N; Thorpe, K, 2018) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 9.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 9.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| "This was a double-blind, randomized, controlled trial in which women with nausea and vomiting of pregnancy were assigned to 4 mg of ondansetron plus a placebo tablet or 25 mg pyridoxine plus 12." | 9.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 9.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described." | 9.17 | Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Miodovnik, M; Umans, J, 2013) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 9.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy." | 9.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 7.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 7.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "The US FDA approval in April 2013 of Diclegis®, the doxylamine-pyridoxine combination for morning sickness, is a major milestone, particularly since it is indicated for use in pregnancy and the FDA has labeled it a pregnancy category A drug the strongest evidence of fetal safety." | 7.79 | The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women. ( Koren, G, 2013) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 7.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 7.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy." | 7.65 | Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1977) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 7.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| " Study drug dosing occurred for 14 days, which is substantially longer than what has been performed in similar studies." | 6.82 | Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2016) |
| " Pharmacokinetic parameters were calculated for each study period using standard, non-compartmental methods, and differences were assessed using ANOVA." | 6.78 | Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy. ( Gill, SK; Koren, G; Macleod, S; Vranderick, M, 2013) |
| " We re-analyzed the 24 primary studies cited in a 1997 meta-analysis that concluded antihistamine use for NVP was safe as they had been studied in more than 200,000 participating women and the pooled odds ratio for congenital malformations was 0." | 6.50 | Re-analysis of safety data supporting doxylamine use for nausea and vomiting of pregnancy. ( Chin, JW; Gregor, S; Persaud, N, 2014) |
| "Doxylamine-pyridoxine is recommended as a first line treatment for nausea and vomiting during pregnancy and it is commonly prescribed." | 5.27 | Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. ( El-Emam, K; Meaney, C; Moineddin, R; Persaud, N; Thorpe, K, 2018) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 5.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 5.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| "This was a double-blind, randomized, controlled trial in which women with nausea and vomiting of pregnancy were assigned to 4 mg of ondansetron plus a placebo tablet or 25 mg pyridoxine plus 12." | 5.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 5.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described." | 5.17 | Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Miodovnik, M; Umans, J, 2013) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 5.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983." | 5.14 | Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age. ( Koren, G; Nulman, I, 2009) |
| "To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy." | 5.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| " We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations." | 5.12 | Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021) |
| " The NVP Healthline enrolled two control groups of women with NVP treated with a doxylamine-pyridoxine combination for morning sickness." | 5.11 | Is lack of morning sickness teratogenic? A prospective controlled study. ( Boskovic, R; Danieliewska-Nikiel, B; Koren, G; Navioz, Y; Rudic, N, 2004) |
| "A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy." | 5.04 | Treatment of pregnancy sickness. ( Wheatley, D, 1977) |
| "For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo." | 4.93 | Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. ( Beyer, F; Bradley, J; Bryant, A; McParlin, C; Moloney, E; Muirhead, CR; Nelson-Piercy, C; Newbury-Birch, D; Norman, J; O'Donnell, A; Robson, SC; Shaw, C; Simpson, E; Swallow, B; Vale, L; Yates, L, 2016) |
| ""Bendectin" (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations." | 4.79 | Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. ( Kutcher, JS; Lamm, SH; Linn, S; McKeigue, PM, 1994) |
| "Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM." | 3.91 | New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019) |
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 3.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 3.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "The US FDA approval in April 2013 of Diclegis®, the doxylamine-pyridoxine combination for morning sickness, is a major milestone, particularly since it is indicated for use in pregnancy and the FDA has labeled it a pregnancy category A drug the strongest evidence of fetal safety." | 3.79 | The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women. ( Koren, G, 2013) |
| "Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada." | 3.77 | Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011) |
| "Women who called the Motherisk NVP helpline, and were taking only Diclectin (vitamin B6 10 mg and doxylamine 10 mg), were enrolled in the study and assessed for the severity of nausea and vomiting of pregnancy (NVP) with the Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system." | 3.72 | Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. ( Boskovic, R; Einarson, A; Koren, G; Maltepe, C; Wolpin, J, 2003) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 3.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| "Several controlled trials show the efficacy of prednisone for nausea and vomiting of pregnancy (NVP), but your case is fascinating in proving the point by challenge-rechallenge." | 3.70 | Managing women with nausea and vomiting of pregnancy. Canadian consensus. ( , 2000) |
| " Although no definitive causative factor has been identified in previously reported cases, the affection in our case is possibly related to Debendox (Bendectin) and nitrofurantoin taken in early pregnancy for nausea and renal tract infection, respectively." | 3.69 | Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy? ( Dubowitz, V; Muntoni, F; Philpot, J; Skellett, S, 1995) |
| "The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects." | 3.67 | The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984) |
| "Doxylamine succinate (DA), a compound which was formerly used as an antinauseant during pregnancy, showed no substantial mutagenicity in mouse embryos following transplacental exposure." | 3.67 | Mutagenicity testing of doxylamine succinate, an antinauseant drug. ( Korte, A; Madle, S; Müller, L, 1989) |
| "Bendectin, composed of doxylamine succinate and pyridoxine HCl (1:1), is an antinauseant previously prescribed for nausea and vomiting during pregnancy." | 3.67 | Developmental toxicity evaluation of Bendectin in CD rats. ( Kimmel, CA; Marr, MC; Price, CJ; Tyl, RW, 1988) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 3.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy." | 3.65 | Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1977) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 3.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| " Study drug dosing occurred for 14 days, which is substantially longer than what has been performed in similar studies." | 2.82 | Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2016) |
| " Pharmacokinetic parameters were calculated for each study period using standard, non-compartmental methods, and differences were assessed using ANOVA." | 2.78 | Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy. ( Gill, SK; Koren, G; Macleod, S; Vranderick, M, 2013) |
| "Compared with ANLL cases not exposed to marijuana, exposed cases were significantly younger at diagnosis of ANLL (P less than 0." | 2.66 | Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the Childrens Cancer Study Group). ( Arthur, DC; Benjamin, D; Buckley, JD; Daigle, AE; Hammond, GD; Robison, LL; Wells, R, 1989) |
| " We re-analyzed the 24 primary studies cited in a 1997 meta-analysis that concluded antihistamine use for NVP was safe as they had been studied in more than 200,000 participating women and the pooled odds ratio for congenital malformations was 0." | 2.50 | Re-analysis of safety data supporting doxylamine use for nausea and vomiting of pregnancy. ( Chin, JW; Gregor, S; Persaud, N, 2014) |
| "Of note, co-existing gastroesophageal reflux disease (GERD), Helicobacter pylori infection, and psychosocial factors may have a negative impact on the management of NVP." | 2.50 | The outpatient management and special considerations of nausea and vomiting in pregnancy. ( Clark, SM; Dutta, E; Hankins, GD, 2014) |
| "Nausea and vomiting are common in early pregnancy." | 2.50 | The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014) |
| "Phenothiazines should be reserved for treating persistent vomiting that threatens the maternal nutritional status." | 2.37 | Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986) |
| " There are different pharmaceutical dosage forms in the European market." | 1.72 | Comparative dissolution profiles of two anti-emetic delayed release dosage forms of doxylamine and pyridoxine: Xonvea® tablets vs. Cariban® capsules. ( Alcocer, C; Gergic, E; Hoarau, D; Iraola, M; Perez de la Cruz, MA; Regidor, PA; Rom, E, 2022) |
| "Two hundred cases of verified brain tumors occurring in patients under 15 years of age were studied in relation to possible etiologic, genetic, and environmental risk factors." | 1.28 | Potential risk factors for brain tumors in children. An analysis of 200 cases. ( Giuffrè, R; Liccardo, G; Pastore, FS; Spallone, A; Vagnozzi, R, 1990) |
| " Two pharmacokinetic experiments were performed in each animal, one on the first day of treatment and one on the last day of treatment." | 1.28 | Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon. ( Denton, R; Hendrickx, AG; Holder, CL; Prahalada, S; Rowland, JM; Slikker, W; Young, JF, 1989) |
| " There was no correlation between dosage and the number of prenatal deaths." | 1.27 | Evaluation of bendectin embryotoxicity in nonhuman primates: II. Double-blind study in term cynomolgus monkeys. ( Booher, S; Cukierski, M; Hendrickx, AG; Janos, G; Nyland, T; Prahalada, S, 1985) |
| " No dose-response relationship was evident." | 1.27 | Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy. ( Birch, JM; Cartwright, RA; Hartley, AL; Hopton, PA; Johnston, HE; Mann, JR; McKinney, PA; Stiller, CA; Waterhouse, JA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 100 (53.76) | 18.7374 |
| 1990's | 20 (10.75) | 18.2507 |
| 2000's | 20 (10.75) | 29.6817 |
| 2010's | 39 (20.97) | 24.3611 |
| 2020's | 7 (3.76) | 2.80 |
| Authors | Studies |
|---|---|
| Alcocer, C | 1 |
| Iraola, M | 1 |
| Rom, E | 1 |
| Hoarau, D | 1 |
| Gergic, E | 1 |
| Perez de la Cruz, MA | 1 |
| Regidor, PA | 1 |
| Panchaud, A | 1 |
| Cleary, B | 1 |
| Weber-Schoendorfer, C | 1 |
| Shechtman, S | 1 |
| Cassina, M | 1 |
| Diav-Citrin, O | 1 |
| Damkier, P | 1 |
| Saz-Leal, P | 1 |
| Zamorano-Domínguez, L | 1 |
| Frías, J | 1 |
| Guerra, P | 1 |
| Saura-Valls, M | 1 |
| Roca-Juanes, R | 1 |
| Nebot-Troyano, J | 1 |
| García-Aguilar, E | 1 |
| Vilchez, T | 1 |
| Urso, K | 1 |
| Wu, XK | 1 |
| Gao, JS | 1 |
| Ma, HL | 1 |
| Wang, Y | 1 |
| Zhang, B | 1 |
| Liu, ZL | 1 |
| Li, J | 1 |
| Cong, J | 1 |
| Qin, HC | 1 |
| Yang, XM | 1 |
| Wu, Q | 1 |
| Chen, XY | 1 |
| Lu, ZL | 1 |
| Feng, YH | 1 |
| Qi, X | 1 |
| Wang, YX | 1 |
| Yu, L | 1 |
| Cui, YM | 1 |
| An, CM | 1 |
| Zhou, LL | 1 |
| Hu, YH | 1 |
| Li, L | 1 |
| Cao, YJ | 1 |
| Yan, Y | 1 |
| Liu, L | 1 |
| Liu, YX | 1 |
| Liu, ZS | 1 |
| Painter, RC | 2 |
| Ng, EHY | 1 |
| Liu, JP | 1 |
| Mol, BWJ | 1 |
| Wang, CC | 1 |
| Fejzo, MS | 1 |
| Trovik, J | 1 |
| Grooten, IJ | 1 |
| Sridharan, K | 1 |
| Roseboom, TJ | 1 |
| Vikanes, Å | 1 |
| Mullin, PM | 1 |
| MacDuffie, KE | 1 |
| Kleinhans, NM | 1 |
| Stout, K | 1 |
| Wilfond, BS | 1 |
| Biffi, A | 1 |
| Rea, F | 1 |
| Locatelli, A | 1 |
| Cetin, I | 1 |
| Filippelli, A | 1 |
| Corrao, G | 1 |
| Kennedy, DS | 1 |
| Batagol, RP | 1 |
| Persaud, N | 5 |
| Meaney, C | 1 |
| El-Emam, K | 1 |
| Moineddin, R | 1 |
| Thorpe, K | 1 |
| Rial, MJ | 1 |
| Fernández-Nieto, M | 1 |
| Rodrigo-Muñoz, JM | 1 |
| Sastre, B | 1 |
| Sastre, J | 1 |
| Del Pozo, V | 1 |
| Bérard, A | 1 |
| Sheehy, O | 1 |
| Gorgui, J | 1 |
| Zhao, JP | 1 |
| Soares de Moura, C | 1 |
| Bernatsky, S | 1 |
| Matok, I | 6 |
| Clark, S | 8 |
| Caritis, S | 4 |
| Miodovnik, M | 8 |
| Umans, J | 2 |
| Hankins, G | 3 |
| Koren, G | 27 |
| Ashkenazi-Hoffnung, L | 1 |
| Merlob, P | 1 |
| Stahl, B | 1 |
| Klinger, G | 1 |
| Feghali, MN | 1 |
| Mattison, DR | 6 |
| Nordeng, H | 1 |
| Vranderick, M | 1 |
| Gill, SK | 2 |
| Macleod, S | 1 |
| Howland, RH | 1 |
| Chin, JW | 1 |
| Gregor, S | 1 |
| Niebyl, JR | 2 |
| Briggs, GG | 1 |
| Hansen, KA | 1 |
| Madjunkova, S | 2 |
| Maltepe, C | 7 |
| Slaughter, SR | 1 |
| Hearns-Stokes, R | 1 |
| van der Vlugt, T | 1 |
| Joffe, HV | 1 |
| Chin, J | 1 |
| Walker, M | 1 |
| Umans, JG | 6 |
| Oliveira, LG | 1 |
| Capp, SM | 1 |
| You, WB | 1 |
| Riffenburgh, RH | 1 |
| Carstairs, SD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Is Zofran Superior to Pyridoxine at Reducing Nausea and Vomiting in Pregnancy[NCT01668069] | 36 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Feasibility and Efficacy of an Internet-delivered Cognitive-behavioral Intervention for Insomnia in a National Cohort of Danish Breast Cancer Survivors[NCT02444026] | 225 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | |||
| The Effect of Adjuvant Hypnosis Added to Conventional Therapy on Nausea and Vomiting in Hyperemesis Gravidarum: A Prospective Randomized Study[NCT04828967] | 41 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| Is the Application of Scopolamine Patch With or Without Intra-operative Acupressure Point P6 Stimulation More Effective Than Intra-operative Acupressure Point P6 Stimulation Alone?[NCT02960113] | Phase 4 | 240 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) after eversion of the uterus. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: After eversion of the uterus until replacement of the uterus
| Intervention | units on a scale (Mean) |
|---|---|
| Scopolamine Patch | 1.28 |
| Acupressure Point P6 | 1.09 |
| Scopolamine Patch + Acupressure Point P6 | 1.40 |
Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) after replacement of the uterus. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: After replacement of the uterus and to the next 15 minutes
| Intervention | units on a scale (Mean) |
|---|---|
| Scopolamine Patch | 2.19 |
| Acupressure Point P6 | 2.19 |
| Scopolamine Patch + Acupressure Point P6 | 2.51 |
Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) after the administration of the regional anesthesia medications. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: From administration of anaesthesia until eversion of uterus
| Intervention | units on a scale (Mean) |
|---|---|
| Scopolamine Patch | 2.71 |
| Acupressure Point P6 | 2.57 |
| Scopolamine Patch + Acupressure Point P6 | 2.84 |
Patients offer their subjective assessments of the level of nausea on a scale of 0-10 (0 = no nausea, 10 = worst nausea ever experienced) upon arrival to the post-operative recovery room. The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea in each group at this point. Patients that report nausea (1 or more on our scale) will be recorded as that they have experienced nausea. (NCT02960113)
Timeframe: 15 minutes after replacement of the uterus to arrival at post-anaesthesia care unit
| Intervention | units on a scale (Mean) |
|---|---|
| Scopolamine Patch | 0.18 |
| Acupressure Point P6 | 0.25 |
| Scopolamine Patch + Acupressure Point P6 | 0.23 |
The investigators will analyze if there is a statistically significant difference between the number of patients that experience nausea at any point during the surgical procedure in each group. (NCT02960113)
Timeframe: Throughout the entire surgical procedure
| Intervention | Participants (Count of Participants) |
|---|---|
| Scopolamine Patch | 40 |
| Acupressure Point P6 | 39 |
| Scopolamine Patch + Acupressure Point P6 | 46 |
The investigators will perform objective assessments of whether or not the patients have vomited during the procedure. The investigators will then analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: Throughout the surgical procedure
| Intervention | Participants (Count of Participants) |
|---|---|
| Scopolamine Patch | 24 |
| Acupressure Point P6 | 25 |
| Scopolamine Patch + Acupressure Point P6 | 31 |
Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: After eversion of to replacement of the uterus
| Intervention | Participants (Count of Participants) |
|---|---|
| Scopolamine Patch | 8 |
| Acupressure Point P6 | 6 |
| Scopolamine Patch + Acupressure Point P6 | 9 |
Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: After replacement of the uterus and for next 15 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Scopolamine Patch | 10 |
| Acupressure Point P6 | 15 |
| Scopolamine Patch + Acupressure Point P6 | 12 |
Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: After the administration of the regional anesthesia medications until eversion of the uterus
| Intervention | Participants (Count of Participants) |
|---|---|
| Scopolamine Patch | 20 |
| Acupressure Point P6 | 15 |
| Scopolamine Patch + Acupressure Point P6 | 20 |
Objective assessments of whether or not the patients have vomited at this point in the surgical procedure will be done. The investigators will analyze if there is a statistically significant difference between the number of patients that vomit in each group. (NCT02960113)
Timeframe: From 15 minutes after replacement of the uterus until arrival at the post-anaesthesia care unit
| Intervention | Participants (Count of Participants) |
|---|---|
| Scopolamine Patch | 1 |
| Acupressure Point P6 | 1 |
| Scopolamine Patch + Acupressure Point P6 | 4 |
Patients are asked their nausea and vomiting treatment satisfaction (0 = Not Satisfied, 10 = Extremely Satisfied). Patients are also asked their overall satisfaction with the procedure (0 = Not Satisfied, 10 = Extremely Satisfied). (NCT02960113)
Timeframe: Throughout the surgical procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Scopolamine Patch | 9.29 |
| Acupressure Point P6 | 8.96 |
| Scopolamine Patch + Acupressure Point P6 | 9.59 |
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
26 reviews available for doxylamine and Pregnancy
| Article | Year |
|---|---|
Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Growth Differentiation Factor 15; H | 2019 |
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2021 |
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines | 2019 |
Re-analysis of safety data supporting doxylamine use for nausea and vomiting of pregnancy.
Topics: Antiemetics; Congenital Abnormalities; Doxylamine; Female; Humans; Morning Sickness; Odds Ratio; Pre | 2014 |
The pharmacologic management of nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N | 2014 |
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
The outpatient management and special considerations of nausea and vomiting in pregnancy.
Topics: Ambulatory Care; Antiemetics; Diet Therapy; Doxylamine; Female; Fluid Therapy; Gastroesophageal Refl | 2014 |
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
Topics: Acupuncture; Adrenal Cortex Hormones; Antiemetics; Doxylamine; Female; Histamine Antagonists; Humans | 2016 |
Clinical practice. Nausea and vomiting in pregnancy.
Topics: Adult; Chorionic Gonadotropin; Complementary Therapies; Diagnosis, Differential; Dicyclomine; Doxyla | 2010 |
Contemporary approaches to hyperemesis during pregnancy.
Topics: Adrenal Cortex Hormones; Antiemetics; Diet; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Obst | 2011 |
Nausea and vomiting of pregnancy.
Topics: Acupressure; Antiemetics; Diagnosis, Differential; Doxylamine; Female; Humans; Hyperemesis Gravidaru | 2003 |
Therapy insight: drugs for gastrointestinal disorders in pregnant women.
Topics: Antiemetics; Constipation; Diarrhea; Doxylamine; Female; Gastroesophageal Reflux; Gastrointestinal D | 2006 |
Teratogen update: bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Dicyclomine; Doxylamine; Drug Combinations; Drug Utilization; | 1983 |
Effects of drugs and chemicals on the fetus and newborn (1).
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug | 1984 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies.
Topics: Abnormalities, Drug-Induced; Antiemetics; Case-Control Studies; Cohort Studies; Dicyclomine; Doxylam | 1994 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6).
Topics: Antiemetics; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Ran | 2000 |
Alternative therapies of morning sickness.
Topics: Acupressure; Antiemetics; Complementary Therapies; Dicyclomine; Doxylamine; Drug Combinations; Femal | 2001 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat | 1990 |
Adverse effects of antihistamines.
Topics: Adolescent; Adult; Aged; Asthma; Brompheniramine; Central Nervous System; Child, Preschool; Chlorphe | 1986 |
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema | 1986 |
Maternal drugs and congenital heart disease.
Topics: Amphetamines; Analgesics; Anticonvulsants; Demography; Disease Susceptibility; Doxylamine; Drug-Rela | 1985 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
22 trials available for doxylamine and Pregnancy
| Article | Year |
|---|---|
Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2
Topics: Acupuncture Therapy; Antiemetics; Child; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Co | 2023 |
Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis.
Topics: Doxylamine; Drug Therapy, Combination; Female; Humans; Morning Sickness; Placebos; Pregnancy; Pyrido | 2018 |
Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy.
Topics: Adolescent; Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxyl | 2013 |
Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; | 2013 |
Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug Combina | 2014 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Doxylamine; Drug Therapy, Combination; Female; Follow-Up St | 2014 |
Comparing pyridoxine and doxylamine succinate-pyridoxine HCl for nausea and vomiting of pregnancy: A matched, controlled cohort study.
Topics: Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morn | 2015 |
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug | 2015 |
Effectiveness of doxylamine-pyridoxine for morning sickness.
Topics: Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morning Sic | 2016 |
Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2016 |
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians | 2017 |
Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age.
Topics: Adult; Antiemetics; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Pr | 2009 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D | 2012 |
Is lack of morning sickness teratogenic? A prospective controlled study.
Topics: Adult; Antiemetics; Congenital Abnormalities; Doxylamine; Female; Genetic Counseling; Humans; Matern | 2004 |
Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum.
Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Administration Schedule; Drug Combinations; Female | 2004 |
Studies support Bendectin safety claim.
Topics: Antiemetics; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; I | 1981 |
FDA to reexamine bendectin data.
Topics: Abnormalities, Drug-Induced; Animals; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combin | 1982 |
Treatment of pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine; | 1977 |
An evaluation of the teratogenicity of certain antinauseant drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami | 1976 |
Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the Childrens Cancer Study Group).
Topics: Adolescent; Age Factors; Antiemetics; Child; Child, Preschool; Dicyclomine; Doxylamine; Drug Combina | 1989 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
139 other studies available for doxylamine and Pregnancy
| Article | Year |
|---|---|
Comparative dissolution profiles of two anti-emetic delayed release dosage forms of doxylamine and pyridoxine: Xonvea® tablets vs. Cariban® capsules.
Topics: Antiemetics; Doxylamine; Female; Gastrointestinal Agents; Humans; Nausea; Pregnancy; Pyridoxine; Sol | 2022 |
The risk of questioning the safety of drugs considered safe in pregnancy at the era of big data: the everlasting case of doxylamine.
Topics: Antiemetics; Doxylamine; Female; Humans; Nausea; Pregnancy | 2022 |
Bioavailability of Cariban
Topics: Adult; Antiemetics; Biological Availability; Capsules; Delayed-Action Preparations; Doxylamine; Drug | 2023 |
Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Ethics, Research; Female; Hu | 2020 |
Confusion about doxylamine safety in pregnancy.
Topics: Antiemetics; Australia; Doxylamine; Female; Humans; Morning Sickness; Pregnancy | 2021 |
Doxylamine Allergy in a Pregnant Woman: Suitability of the Basophil Activation Test.
Topics: Adult; Basophils; Doxylamine; Female; Humans; Hypersensitivity; Pregnancy | 2018 |
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi | 2019 |
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations | 2013 |
The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; | 2013 |
Diclegis for nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2013 |
Characteristics of women with nausea and vomiting of pregnancy who chose to continue compassionate use of placebo after a randomised trial.
Topics: Adult; Dicyclomine; Double-Blind Method; Doxylamine; Drug Combinations; Female; Histamine H1 Antagon | 2013 |
Concern for truth: driving defensively when confronting a zombie epidemic.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor | 2013 |
Diclegis: return of a medication.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Female; Humans; Morning Sick | 2013 |
FDA approval of doxylamine-pyridoxine therapy for use in pregnancy.
Topics: Antiemetics; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Fe | 2014 |
Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Treating morning sickness in the United States--changes in prescribing are needed.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Female; Heart Defects, Conge | 2014 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
Odansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
In reply.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
Flawed invisible trial underpins US morning sickness drug, researchers say.
Topics: Antiemetics; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Fe | 2017 |
Motherisk and Canadian Family Physician.
Topics: Canada; Doxylamine; Female; Guideline Adherence; Humans; Hyperemesis Gravidarum; Physicians, Family; | 2017 |
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam | 2009 |
Sleep complaints: Whenever possible, avoid the use of sleeping pills.
Topics: Acupuncture Therapy; Adult; Aged; Behavior Therapy; Benzodiazepines; Clinical Trials as Topic; Conge | 2008 |
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl | 2011 |
Epidemiological evidence in forensic pharmacovigilance.
Topics: Abnormalities, Drug-Induced; Antiemetics; Breast Implantation; Causality; Connective Tissue Diseases | 2012 |
Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis.
Topics: Anti-Bacterial Agents; Confounding Factors, Epidemiologic; Dicyclomine; Doxylamine; Drug Combination | 2003 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
Bendectin in the treatment of nausea of pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1957 |
Nausea and vomiting of pregnancy: treatment with bendectin.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1958 |
Bendectin in the treatment of nausea and vomiting in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1959 |
Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Humans; | 2003 |
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe | 2007 |
Preventing recurrence of severe morning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morning Sickness; Ondansetr | 2006 |
The risk of risk reduction: can postmarket surveillance pose more risk than benefit?
Topics: Antiemetics; Data Collection; Defibrillators, Implantable; Device Approval; Disclosure; Doxylamine; | 2007 |
Safety of Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetal Death; Humans | 1981 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Humans; Infa | 1981 |
Bendectin (Debendox) and congenital diaphragmatic hernia.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Hernia, Diaphragmatic; Herni | 1983 |
Bendectin (debendox) and congenital diaphragmatic hernia.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Hernias, Diaphragmatic, Congenital; | 1983 |
Chromosomal studies on children with phocomelia, exposed to debendox during early pregnancy.
Topics: Chromosome Inversion; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Female; Humans; Infant | 1983 |
Teratogenicity of debendox and pyrimethamine.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1983 |
Debendox is not thalidomide.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1984 |
Our bundle of responsibility. Presidential address.
Topics: Abnormalities, Drug-Induced; Costs and Cost Analysis; Delivery of Health Care; Dicyclomine; Doxylami | 1984 |
Pyloric stenosis and maternal Bendectin exposure.
Topics: Adult; Dicyclomine; Doxylamine; Drug Combinations; Drug Prescriptions; Female; Follow-Up Studies; Hu | 1984 |
Possible association of use of bendectin during early pregnancy and congenital lung hypoplasia.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1984 |
Debendox and pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre | 1984 |
Debendox: a statement from the New Zealand Adverse Drug Reactions Committee.
Topics: Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1984 |
No more bendectin.
Topics: Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1983 |
Bendectin and pyloric stenosis.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Pregnancy; | 1983 |
Bendectin: the wrong way to regulate drug availability.
Topics: Abnormalities, Drug-Induced; Canada; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Fema | 1983 |
Nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
Bendectin: a case of mourning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
Two legal issues: expert witnesses and Bendectin case.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Expert Testimony; Female; Humans; Jurisprudence; Pregnan | 1983 |
Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis | 1983 |
Bendectin and pyloric stenosis in infants.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange | 1983 |
Additional follow-up of congenital limb disorders in relation to Bendectin use.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Follow | 1983 |
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; | 1984 |
Good-bye, Bendectin, old friend.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1984 |
Debendox withdrawn.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1984 |
Product liability all dressed up American style.
Topics: Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinations; Drug Industry; Drug Lab | 1981 |
Debendox in early pregnancy and fetal malformation.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1981 |
Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Estradiol; Fem | 1983 |
Congenital malformations.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Combinations; F | 1983 |
The Bendectin Saga: another American tragedy (Brent, '80).
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1983 |
Debendox in the dock.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
Bendectin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1982 |
New Zealand committee on adverse drug reactions: fourteenth annual report 1979.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Child, Preschool; Doxylamine; Drug Synergism; | 1980 |
Bendectin and fetal development. A study of Boston City Hospital.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1982 |
Bendectin PPI available.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Labeling; Female; Humans; Patient Educ | 1982 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine; | 1982 |
Bendectin (Debendox) as a risk factor for pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Adult; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart Defect | 1982 |
The law and Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1981 |
Indications for bendectin narrowed.
Topics: Antiemetics; Carcinogens; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; Pre | 1981 |
Is Bendectin a teratogen?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluatio | 1981 |
Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects.
Topics: Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; F | 1981 |
Congenital anomalies in relation to the use of doxylamine/dicyclomine and other antenatal factors: an ongoing prospective study.
Topics: Abnormalities, Drug-Induced; Adult; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combi | 1981 |
Debendox and limb reduction deformities.
Topics: Abnormalities, Drug-Induced; Australia; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug C | 1981 |
A dearth of new drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Doxylamine; Drug Combinations; Drug Evaluation; Drug Evalu | 1980 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1980 |
The ingestion by pregnant women of substances toxic to the foetus.
Topics: Abnormalities, Drug-Induced; Barbiturates; Clitoris; Diazepam; Disorders of Sex Development; Doxylam | 1980 |
How safe is Bendectin?
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; Female; Hu | 1980 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
The Bendectin debate.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Femal | 1980 |
Public health issues: bendectin, love canal.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; New York; Pregnancy; Pyridines; Pyridoxi | 1981 |
Bendectin and fetal malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1981 |
Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy?
Topics: Age of Onset; Antiemetics; Arm; Dermatoglyphics; Diagnosis, Differential; Dicyclomine; Doxylamine; D | 1995 |
Science, law, and the search for truth in the courtroom: lessons from Daubert v. Merrell Dow.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1994 |
Admissibility of scientific testimony into evidence.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; | 1994 |
Study of prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1993 |
Environmental hazards: real or exaggerated?
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Hazardous Substances; Humans; Pregnancy; Pyridox | 1993 |
Supreme Court to weigh science.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1993 |
Bringing scholarship to the courtroom: the Daubert decision and its impact on the Teratology Society.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Ethics, Professional; Expert Testimony; Female; Humans; | 1995 |
Drug therapies for hyperemesis gravidarum.
Topics: Administration, Oral; Antiemetics; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Infusions, In | 1997 |
Pregnancy outcome of women exposed to pinaverium due to a dispensing error.
Topics: Antiemetics; Calcium Channel Blockers; Canada; Dicyclomine; Doxylamine; Drug Combinations; Female; F | 1999 |
From science to evidence: the testimony on causation in the Bendectin cases.
Topics: Abnormalities, Drug-Induced; Data Collection; Decision Making; Doxylamine; Drug Combinations; Expert | 1993 |
Managing women with nausea and vomiting of pregnancy. Canadian consensus.
Topics: Adult; Anti-Inflammatory Agents; Antiemetics; Asthma; Diagnosis, Differential; Doxylamine; Drug Ther | 2000 |
Tort liability and the availability of contraceptive drugs and devices in the United States.
Topics: Antiemetics; Breast Implants; Contraceptive Agents; Delivery of Health Care; Doxylamine; Drug Indust | 1997 |
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di | 2000 |
The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy.
Topics: Antiemetics; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Nausea; Pregnancy; Preg | 2001 |
CDC study: no evidence for teratogenicity of Bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart | 1979 |
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1978 |
Unusual fetal malformations after antiemetics in early pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Female; Humans; Pregnancy | 1978 |
Fetal malformation after Debendox treatment in early pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1978 |
Congenital deformities associated with Benedectin.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1977 |
Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.
Topics: Abnormalities, Drug-Induced; Birth Weight; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Env | 1977 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Fe | 1992 |
Risk, statistical inference, and the law of evidence: the use of epidemiological data in toxic tort cases.
Topics: Abnormalities, Drug-Induced; Antiemetics; Confidence Intervals; Data Interpretation, Statistical; Di | 1992 |
Potential risk factors for brain tumors in children. An analysis of 200 cases.
Topics: Adolescent; Brain Neoplasms; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; Glioma; Huma | 1990 |
Drugs in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyrid | 1990 |
Bendectin--birth defects controversy.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Extre | 1990 |
Key witness against morning sickness drug faces scientific fraud charges.
Topics: Animals; Antiemetics; Australia; Biomedical Research; Dicyclomine; Doxylamine; Drug Combinations; Fe | 1990 |
Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon.
Topics: Animals; Chromatography, Gas; Dicyclomine; Doxylamine; Drug Combinations; Female; Half-Life; Macaca | 1989 |
Bendectin and human congenital malformations.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do | 1989 |
Mutagenicity testing of doxylamine succinate, an antinauseant drug.
Topics: Animals; Antiemetics; Bone Marrow; Chromosome Aberrations; Cricetinae; Cricetulus; Doxylamine; Embry | 1989 |
Embryo-maternal distribution of basic compounds in the CD-1 mouse: doxylamine and nicotine.
Topics: Animals; Biological Transport; Doxylamine; Embryo, Mammalian; Female; Hydrogen-Ion Concentration; Ma | 1989 |
Bendectin and interventricular septal defects.
Topics: Centers for Disease Control and Prevention, U.S.; Dicyclomine; Doxylamine; Drug Combinations; Female | 1985 |
Agenesis of the corpus callosum and neural crest tumors.
Topics: Abdominal Neoplasms; Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Child; Child, Prescho | 1986 |
Discontinuation of Bendectin.
Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; P | 1988 |
Factors associated with infantile hypertrophic pyloric stenosis.
Topics: Birth Order; Breast Feeding; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hypertrophy | 1988 |
Developmental toxicity evaluation of Bendectin in CD rats.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1988 |
The value of case reports in human teratology.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth | 1986 |
Debendox.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1986 |
The management of nausea and vomiting during pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea; | 1987 |
Limb-reduction deformities and Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1987 |
The weight of the evidence--or--more likely than not.
Topics: Abnormalities, Drug-Induced; Dicyclomine; District of Columbia; Doxylamine; Drug Combinations; Femal | 1986 |
Drugs and stillbirth.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Contraceptives, Oral; Dicyclomine; Doxyla | 1986 |
The debendox saga.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1985 |
Debendox.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1986 |
Jury clears Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1985 |
First-trimester drug use and congenital disorders.
Topics: Abnormalities, Drug-Induced; Brompheniramine; Congenital Abnormalities; Dicyclomine; Doxylamine; Dru | 1985 |
Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy.
Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Antiemetics; Aspirin; Dicyclomine; Doxylamine; Drug Com | 1985 |
Blame, compensation and birth defects.
Topics: Abnormalities, Drug-Induced; Australia; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Comb | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
Evaluation of bendectin embryotoxicity in nonhuman primates: I. Ventricular septal defects in prenatal macaques and baboon.
Topics: Animals; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Fetus | 1985 |
Evaluation of bendectin embryotoxicity in nonhuman primates: II. Double-blind study in term cynomolgus monkeys.
Topics: Animals; Brain; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Method; Doxylamine; Drug | 1985 |
Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy.
Topics: Adolescent; Antiemetics; Child; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship | 1985 |
Circadian aspects of prostaglandin F2alpha-induced termination of pregnancy.
Topics: Abortion, Induced; Abortion, Therapeutic; Adult; Amniotic Fluid; Circadian Rhythm; Dextropropoxyphen | 1974 |