Page last updated: 2024-08-22

doxifluridine and Neoplasms

doxifluridine has been researched along with Neoplasms in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (35.90)	18.7374
1990's	12 (30.77)	18.2507
2000's	6 (15.38)	29.6817
2010's	5 (12.82)	24.3611
2020's	2 (5.13)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L	1
Li, K; Liu, J; Si, S; Xu, J; Xue, P	1
Jiang, WL; Li, CY; Mao, GJ; Tan, M; Tan, ZK; Wang, WX	1
Beijnen, JH; Cats, A; de Vries, N; Deenen, MJ; Huitema, ADR; Jacobs, BAW; Joerger, M; Meulendijks, D; Rosing, H; Schellens, JHM	1
He, S; Jiang, Y; Pu, K; Xie, C	1
Chen, X; Dai, X; Deng, P; Ding, L; Ji, C; Zhong, D	1
Chang, Y; Chen, Y; Fan, H; Fang, F; Gupta, N; Kong, X; Liang, J; Liu, X; Wang, R	1
Harada, N; Kurasawa, M; Mori, K; Sato, Y; Yanagisawa, M; Yasuno, H	1
Cao, D; Pizzorno, G	1
Bacsó, Z; Eliason, JF; Megyeri, A; Shields, A	1
Lokiec, F; Rezaí, K; Urien, S	1
Baldwin, J; Basche, M; Britten, CD; Camidge, DR; Darstein, C; Finn, RS; Gail Eckhardt, S; Gore, L; Holden, SN; Leong, S; Musib, L; O'Bryant, CL; Thornton, D	1
Abele, R; Alberto, P; Bollag, W; Germano, G; Heintz, R; Seematter, RJ	1
Armstrong, RD; Cadman, E	1
Hara, Y; Ishitsuka, H; Karube, Y; Kono, A; Matsushima, Y; Sugata, S	1
Armstrong, RD; Cadman, E; Gesmonde, J; Wu, T	1
Kimura, K; Suga, S	1
Hara, Y	1
Urushizaki, I	1
Antimi, M; Majoli, L; Minelli, M; Pandolfi, A; Papa, G; Stampino, CG	1
Palmisano, F; Zambonin, CG	1
Hino, A; Ishitsuka, H; Matsumoto, T; Mori, K; Nishida, M; Yoshikubo, T	1
Paillard, F	1
Denning, C; Pitts, JD	1
Ishikawa, T; Ishitsuka, H; Miwa, M; Mori, K; Nishida, M; Sawada, N; Shimma, N; Umeda, I; Ura, M	1
González Barón, M	1
De Bruijn, EA; Highley, MS; Maes, RA; Reeuwijk, HJ; Tjaden, UR; Van Der Heyden, SA; Van Oosterom, AT; Van Slooten, H	1
Ebata, K; Endo, M; Horiuchi, J; Kamata, R; Saito, T; Sanuki, E; Sato, K; Sekiguchi, K; Shibuya, H; Yamashita, T	1
Bishop, JF; Guentert, TW; Hill, HS; Hillcoat, BL; Morris, RG; Olver, IN; Reece, PA	1
Bishop, JF; Guentert, TW; Hillcoat, BL; Morris, RG; Olver, IN; Reece, PA	1
Alberto, P; Bruyere, A; Decoster, G; Holdener, EE; Paschoud, N; Peytremann, R; Righetti, A; Winkelmann, JJ	1
Furue, H; Kanamaru, R; Kimura, K; Komita, T; Murakami, M; Nakao, I; Ohta, K; Saito, T; Wakui, A; Yokoyama, M	1
Abe, O; Kimura, K; Kimura, T; Kurihara, M; Nakao, I; Niitani, H; Ohta, K; Saito, T; Urushizaki, I; Yoshida, Y	1
Irie, K; Kawahara, T; Okajima, K; Sakai, K; Satomi, T; Taguchi, T; Terasawa, T; Tomita, K; Yamaguchi, A; Yamamoto, M	1
Okumura, T	1
Armand, JP; Bastit, P; Cappelaere, P; Fargeot, P; Fumoleau, P; Hurteloup, P; Keiling, R; Kerbrat, P; Metz, R; Schraub, S	1
Ishitsuka, H; Kamiyama, T; Miwa, M; Nishimura, J	1
Tsukagoshi, S	1

Reviews

3 review(s) available for doxifluridine and Neoplasms

Article	Year
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nature cell biology, 2015, Volume: 17, Issue:11 Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction	2015
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation. Drugs of today (Barcelona, Spain : 1998), 2004, Volume: 40, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Neoplasms; Pyrimidines; Uridine; Uridine Phosphorylase	2004
[Oral fluoropyrimidines in oncology]. Anales de la Real Academia Nacional de Medicina, 1998, Volume: 115, Issue:3 Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil	1998

Trials

6 trial(s) available for doxifluridine and Neoplasms

Article	Year
Simultaneous determination of capecitabine and its three nucleoside metabolites in human plasma by high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, May-01, Volume: 989 Topics: Antimetabolites, Antineoplastic; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Male; Neoplasms; Tandem Mass Spectrometry; Therapeutic Equivalency	2015
Pharmacokinetic modelling of 5-FU production from capecitabine--a population study in 40 adult patients with metastatic cancer. Journal of pharmacokinetics and pharmacodynamics, 2005, Volume: 32, Issue:5-6 Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Irinotecan; Middle Aged; Models, Biological; Molecular Structure; Neoplasm Metastasis; Neoplasms; Prodrugs; Sesquiterpenes	2005
A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors. Anti-cancer drugs, 2008, Volume: 19, Issue:1 Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cohort Studies; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Indoles; Male; Middle Aged; Monocytes; Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase C beta	2008
A phase I safety study of doxifluridine and interferon-alpha-2a in patients with advanced neoplastic disease. Tumori, 1993, Oct-31, Volume: 79, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Neoplasms; Recombinant Proteins	1993
[Multi-institutional trials of radiation and Furtulon combination therapy for malignant tumors]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:5 Topics: Administration, Oral; Antineoplastic Agents; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Neoplasms; Radiotherapy Dosage	1992
[Clinical trial of 5'-DFUR against various malignant tumors]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:12 Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasms; Stomach Neoplasms	1985

Other Studies

30 other study(ies) available for doxifluridine and Neoplasms

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Construction of synergistic pH/H Bioorganic chemistry, 2022, Volume: 119 Topics: A549 Cells; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Liberation; Floxuridine; HeLa Cells; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Molecular Structure; Neoplasms; Optical Imaging; Prodrugs; Structure-Activity Relationship; Tumor Microenvironment	2022
A novel near-infrared theranostic probe for accurate cancer chemotherapy Chemical communications (Cambridge, England), 2021, Dec-16, Volume: 57, Issue:100 Topics: Animals; Antineoplastic Agents; Boronic Acids; Cell Line, Tumor; Coumarins; Floxuridine; Fluorescent Dyes; HEK293 Cells; Humans; Hydrogen Peroxide; Male; Mice, Inbred BALB C; Neoplasms; Optical Imaging; Precision Medicine; Thymidine Phosphorylase	2021
Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis. CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:12 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Gastrectomy; Humans; Male; Middle Aged; Neoplasms; Pharmacogenomic Variants; Prodrugs	2019
An Organic Afterglow Protheranostic Nanoassembly. Advanced materials (Deerfield Beach, Fla.), 2019, Volume: 31, Issue:32 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dimerization; Drug Delivery Systems; Floxuridine; Hydrogen Peroxide; Infrared Rays; Luminescent Agents; Mice; Nanoparticles; Neoplasms; Polyethylene Glycols; Prodrugs; Theranostic Nanomedicine; Tissue Distribution; Tumor Microenvironment; Uridine	2019
Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Molecular pharmacology, 2009, Volume: 76, Issue:4 Topics: Antimetabolites, Antineoplastic; Base Sequence; Cell Line, Tumor; Cell Proliferation; DNA Primers; Electrophoretic Mobility Shift Assay; Enzyme Induction; ERRalpha Estrogen-Related Receptor; Floxuridine; Humans; Neoplasms; Polymerase Chain Reaction; Receptors, Estrogen; Transcription Factors; Transcription, Genetic; Uridine Phosphorylase	2009
Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes. Oncology reports, 2013, Volume: 29, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Mice; Mice, Nude; Neoplasms; Nucleoside-Phosphate Kinase; Orotate Phosphoribosyltransferase; Ribonucleotide Reductases; RNA, Messenger; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Uridine Kinase; Uridine Phosphorylase	2013
Development of a stereological method to measure levels of fluoropyrimidine metabolizing enzymes in tumor sections using laser scanning cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2005, Volume: 64, Issue:2 Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Dihydrouracil Dehydrogenase (NADP); Esophageal Neoplasms; Floxuridine; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Laser Scanning Cytometry; Neoplasms; Pyrimidines; Thymidine Phosphorylase	2005
Phase I clinical study with 5'-deoxy-5-fluorouridine, a new fluoropyrimidine derivative. Cancer treatment reports, 1982, Volume: 66, Issue:6 Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Half-Life; Humans; Kinetics; Leukocyte Count; Leukopenia; Male; Middle Aged; Neoplasms; Platelet Count; Stomatitis; Thrombocytopenia	1982
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. Cancer research, 1983, Volume: 43, Issue:6 Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Neoplasms; Osteosarcoma	1983
Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors. Chemical & pharmaceutical bulletin, 1983, Volume: 31, Issue:1 Topics: Animals; Biotransformation; Floxuridine; Guinea Pigs; Humans; Male; Mice; Middle Aged; Neoplasms; Pentosyltransferases; Thymidine Phosphorylase	1983
Cytotoxic activity of 5'-deoxy-5-fluorouridine in cultured human tumors. Cancer treatment reports, 1983, Volume: 67, Issue:6 Topics: Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Female; Floxuridine; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Neoplasms; Osteosarcoma; Pancreatic Neoplasms	1983
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives]. Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur; Uracil	1982
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:10 Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms; Pentosyltransferases; Pyrimidine Phosphorylases; Sarcoma, Experimental; Stomach Neoplasms; Uridine Phosphorylase; Uterine Neoplasms	1984
[Chemotherapy for older cancer patients]. Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:7 Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Drug Administration Schedule; Etoposide; Female; Floxuridine; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Neoplasms; Neoplasms, Multiple Primary; Palliative Care; Quality of Life	1993
Gas chromatography-mass spectrometry identification of a novel N3-methylated metabolite of 5'-deoxy-5-fluorouridine in plasma of cancer patients undergoing chemotherapy. Journal of pharmaceutical and biomedical analysis, 1996, Volume: 14, Issue:11 Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Floxuridine; Gas Chromatography-Mass Spectrometry; Humans; Neoplasms; Prodrugs; Reference Standards	1996
Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:11 Topics: Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Thymidine Phosphorylase	1996
Bystander effects in enzyme/prodrug gene therapy. Human gene therapy, 1997, Oct-10, Volume: 8, Issue:15 Topics: Antineoplastic Agents; Floxuridine; Ganciclovir; Gap Junctions; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Neoplasms; Prodrugs; Thymidine Kinase; Thymidine Phosphorylase	1997
Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes. Human gene therapy, 1997, Oct-10, Volume: 8, Issue:15 Topics: Animals; Apoptosis; Cell Communication; Cell Line; Cricetinae; Drug Synergism; Floxuridine; Ganciclovir; Gap Junctions; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Mice; Neoplasms; Prodrugs; Thymidine Kinase; Thymidine Phosphorylase; Tumor Cells, Cultured	1997
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:8 Topics: Animals; Capecitabine; Carboxylic Ester Hydrolases; Cytidine Deaminase; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Liver; Male; Mice; Neoplasms; Thymidine Phosphorylase	1998
Pharmacokinetics and bioavailability of oral 5'-deoxy-5-fluorouridine in cancer patients. British journal of clinical pharmacology, 1999, Volume: 47, Issue:4 Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Biological Availability; Female; Floxuridine; Humans; Middle Aged; Neoplasms	1999
Pharmacokinetic study of doxifluridine given by 5-day stepped-dose infusion. Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:4 Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms	1990
A phase I study of doxifluridine as a five-day stepped-dose continuous infusion. American journal of clinical oncology, 1990, Volume: 13, Issue:4 Topics: Adult; Aged; Antineoplastic Agents; Cohort Studies; Dose-Response Relationship, Drug; Drug Evaluation; Female; Floxuridine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Remission Induction	1990
Phase I study of oral doxifluridine using two schedules. European journal of cancer & clinical oncology, 1989, Volume: 25, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Female; Floxuridine; Humans; Isomerism; Male; Middle Aged; Neoplasms	1989
[Phase I study of 5'-deoxy-5-fluorouridine (5'-DFUR)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:10 Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Leukocyte Count; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasms	1985
[Phase II study of 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with malignant cancer--a multi-institutional cooperative study]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:10 Topics: Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Leukopenia; Male; Nausea; Neoplasms; Stomach Neoplasms	1985
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group]. Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:11 Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nausea; Neoplasms; Rectal Neoplasms; Stomach Neoplasms	1985
Phase II clinical evaluation of doxifluridine. Cancer treatment reports, 1986, Volume: 70, Issue:6 Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Diseases; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine; Heart Diseases; Hematologic Diseases; Humans; Infusions, Parenteral; Kidney Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Nausea; Neoplasms; Rectal Neoplasms	1986
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients]. Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10 Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Leukemia P388; Mice; Neoplasms; Neoplasms, Experimental; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Sarcoma 180	1987
[A new anticancer drug, 5'-deoxy-5-fluorouridine (5'-DFUR)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10 Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Floxuridine; Humans; Male; Middle Aged; Neoplasms	1987