doxifluridine has been researched along with Colorectal Neoplasms in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.03) | 18.7374 |
| 1990's | 25 (37.88) | 18.2507 |
| 2000's | 25 (37.88) | 29.6817 |
| 2010's | 14 (21.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chionh, F; Lau, D; Price, T; Tebbutt, N; Yeung, Y | 1 |
| Fujita, KI; Ishida, H; Ishikawa, F; Kubota, Y; Ohkuma, R; Sasaki, Y; Sekido, M; Shibanuma, M; Takahashi, T; Tsunoda, T | 1 |
| Araki, A; Eto, R; Hazama, S; Hinoda, Y; Kanekiyo, S; Kondo, H; Nagashima, A; Oka, M; Okayama, N; Shimizu, R; Uchiyama, T; Yamamoto, T; Yoshida, S; Yoshino, S | 1 |
| Albain, KS; Blanke, CD; Coleman, D; Ely, B; Gold, PJ; Gotay, C; Lenz, HJ; Louie, SG; Raghavan, D; Shields, AF | 1 |
| Czejka, M; Dittrich, C; Gintersdorfer, S; Kitzmueller, M; Lichtneckert, M; Neudorfer, C; Poxhofer, M; Schreiber, V | 1 |
| Buchner, P; Czejka, M; Farkouh, A; Georgopoulos, A; Gruenberger, B; Scheithauer, W; Schueller, J | 1 |
| Liu, Q; Wang, Q; Ye, D; Zhang, J | 1 |
| Hoshino, S; Maekawa, T; Mikami, K; Sakai, T; Shirakusa, T; Yamashita, Y | 1 |
| Abe, R; Fujiwara, H; Fukuyama, N; Hirano, T; Hirata, K; Hotokezaka, M; Imamura, T; Ito, H; Iwashita, A; Kato, H; Konomi, K; Kuroki, N; Miyazaki, R; Miyazaki, Y; Nakahara, S; Nakano, S; Sakamoto, Y; Shimokobe, T; Shiraishi, M; Terasaka, R | 1 |
| Araki, A; Hazama, S; Hinoda, Y; Kondo, H; Nagashima, A; Oka, M; Okayama, N; Shimizu, R; Yoshida, S; Yoshino, S | 1 |
| Czejka, M; Farkouh, A; Gruenberger, B; Scheithauer, W; Schueller, J | 1 |
| Chen, Y; Liu, Q; Luo, J; Wang, J; Wang, X; Yan, Z | 1 |
| Honda, T; Inagawa, H; Nishizawa, T; Soma, G; Yamamoto, I; Yoshimura, H | 1 |
| Chae, YS; Choi, GS; Jang, YS; Jeon, SW; Jun, SH; Jung, MK; Kang, BW; Kim, JG; Lee, SJ; Lim, KH; Moon, JH; Park, JS; Sohn, SK | 1 |
| Bellot, GL; Koh, D; Tan, WH; Tay, LL; Wang, X | 1 |
| Hashizume, T; Kato, T; Kotake, K; Mori, T; Ohue, M; Sato, T; Takii, Y; Tango, T | 1 |
| Ahn, JH; Kang, YK; Kim, JC; Kim, JG; Kim, TW; Kim, WK; Lee, JH; Lee, JS; Min, YJ; Yu, CS | 1 |
| Ishikawa, T; Ouchi, KF; Tanaka, Y; Yanagisawa, M | 1 |
| Blesch, KS; Burger, HU; Gieschke, R; Reigner, B; Steimer, JL | 1 |
| Koda, K; Kodaira, S; Miyazaki, M; Nakazato, H; Ogawa, K; Saito, N; Sarashina, H; Suwa, T; Suzuki, M; Watanabe, S | 1 |
| Miwa, K; Nishimura, G | 1 |
| Heerschap, A; Kamm, YJ; Klomp, DW; Punt, CJ; van Laarhoven, HW | 1 |
| Liu, MJ; Matsuno, S; Mizoi, T; Sasak, I; Shiiba, K; Zhang, JM | 1 |
| Creer, S; Ishii, H; Kuroki, T; Mimori, K; Mori, M; Shiraishi, T; Taylor, S; Ueo, H | 1 |
| Hiro, J; Inoue, Y; Kobayashi, M; Kusunoki, M; Miki, C; Mori, K; Shirane, M; Tanaka, K; Yanagi, H | 1 |
| Hasegawa, R; Hasegawa, S; Koda, K; Miyazaki, M; Oda, K; Seike, K; Takiguchi, N | 1 |
| Fujimoto-Ouchi, K; Kato, T; Kikkawa, N; Mishima, H; Nishisho, I; Tanaka, Y; Tsujie, M; Tsujinaka, T; Yanagisawa, M | 1 |
| Hirose, K; Nishimura, M; Sawada, T | 1 |
| Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Ogo, S; Ohkita, A; Ozasa, H; Sasatomi, T; Shirouzu, K | 1 |
| Guichard, SM; Jodrell, DI; Mayer, I | 1 |
| Akagi, Y; Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Mori, S; Murakami, H; Ogata, Y; Ozasa, H; Shirouzu, K | 1 |
| Aoyagi, Y; Haku, K; Hayama, T; Matsuda, K; Mimura, T; Nakamura, K; Nozawa, K; Oomi, T; Watanabe, T; Yamada, H | 1 |
| Amano, M; Fukunaga, M; Ikeda, K; Ikeda, M; Ikenaga, M; Ishida, H; Kato, T; Mishima, H; Monden, M; Murata, K; Ohnishi, T; Ota, H; Sakamoto, J; Sekimoto, M; Tominaga, S | 1 |
| Higashijima, J; Kurita, N; Miyamoto, H; Miyatani, T; Nishioka, M; Shimada, M; Yoshikawa, K | 1 |
| Bajetta, E; Bozzetti, F; Buzzoni, R; Cappuzzo, F; Colleoni, M; Di Bartolomeo, M; Doci, R; Guenzi, A; Somma, L; Stampino, CG | 1 |
| Barduagni, M; Bertuccelli, M; Calabresi, F; Carrai, M; Ceribelli, A; Cianci, C; De Marco, S; Falcone, A; Pfanner, E; Ricci, S | 1 |
| Mori, T; Takahashi, K; Takahashi, T | 1 |
| Hiratsuka, M; Imaoka, S; Ishikawa, O; Kabuto, T; Kameyama, M; Nakamori, S; Nakano, H; Ohigashi, H; Sasaki, Y; Yasuda, T | 1 |
| Haruta, A; Ikeda, S; Jyozaki, H; Tanaka, S; Toriya, H; Umeno, T | 1 |
| Hachisuka, K; Honda, H; Honda, K; Maeda, A; Nakazato, H; Tsuruga, N; Yamaguchi, A; Yoshizaki, S; Yura, J | 1 |
| Hanyu, F; Hayashi, T; Igarashi, T; Suzuki, M; Watanabe, K; Yoshida, K | 1 |
| Amadori, D; Bajetta, E; Calabresi, F; Colleoni, M; Comella, G; Lorusso, V; Marangolo, M; Rosso, R; Scanni, A; Sobrero, A | 1 |
| Fujiwara, T; Hizuta, A; Iwagaki, H; Orita, K; Perdomo, JA; Tanaka, N | 1 |
| Bajetta, E; Bordogna, G; Comella, G; Di Bartolomeo, M; Gebbia, V; Moreschi, M; Scanni, A; Somma, L; Stampino, CG; Turci, D | 1 |
| Doi, O; Furukawa, H; Hiratsuka, M; Imaoka, S; Ishikawa, O; Iwanaga, T; Kabuto, T; Kameyama, M; Nakamori, S; Ohigashi, H; Sasaki, Y; Yasuda, T; Yokouchi, H | 1 |
| Ariga, T; Kinoshita, H; Maeda, T; Maruyama, T; Ohshima, I; Ozaki, M; Shimada, H; Shoko, T; Takeda, A; Yoshimura, S | 1 |
| Baba, H; Kohnoe, S; Matsuoka, H; Morita, M; Saito, T; Seo, Y; Taketomi, A; Tomoda, H | 1 |
| Artale, S; Bajetta, E; Bignami, P; Buzzoni, R; Del Vecchio, M; Di Bartolomeo, M; Magnani, E; Somma, L; Zunino, F | 1 |
| Furukawa, H; Hiratsuka, M; Imaoka, S; Ishikawa, O; Kabuto, T; Kameyama, M; Murata, K; Nakano, H; Ohigashi, H; Sasaki, Y; Tsugawa, T; Yasuda, T | 1 |
| Amano, M; Haba, A; Ikeda, K; Izawa, H; Kanoh, T; Monden, M; Monden, T; Ohnishi, T; Okamura, J; Sekimoro, M; Tomita, N; Tsujie, M | 1 |
| Horie, H; Hosoya, Y; Ishizuka, T; Kanazawa, K; Kashiwagi, H; Kojima, M; Konishi, H; Shitou, K | 1 |
| Chimori, Y; Fujita, Y; Ikoma, H; Nanri, M; Oguro, A; Yamane, E | 1 |
| Agostino, I; Andreoli, F; Bartolini, P; Gemelli, MT; Neri, B; Pantalone, D; Pernice, ML; Scatizzi, M; Siliani, GM | 1 |
| Fushimi, H; Hazama, K; Honda, M; Inoue, Y; Matsuo, Y; Takao, T; Tanaka, Y; Yamamoto, S | 1 |
| Cano, JP; Ciccolini, J; Cuq, P; Evrard, A; Vian, L | 1 |
| Amano, M; Haba, A; Monden, M; Monden, T; Ohue, M; Sakita, I; Sekimoto, M; Tamaki, Y; Tomita, N | 1 |
| Baba, H; Ebuchi, M; Kure, N; Maruyama, M; Nagahama, T; Toukairin, Y; Yoshida, T | 1 |
| Kato, S; Onda, M; Tanaka, N; Tanaka-Nozaki, M | 1 |
| Fujita, H; Hiki, Y; Ike, H; Mitomi, T; Otani, Y; Oya, K; Sadahiro, S; Shimada, H; Yamaguchi, S | 1 |
| Fujioka, M; Hashimoto, D; Hoshino, T; Inokuma, S; Ishida, H; Ishizuka, N; Matsumoto, Y; Miura, T; Murata, N; Nakada, H; Odaka, A; Ohsawa, T; Takeuchi, I; Yamada, H; Yokoyama, M | 1 |
| Bajetta, E; Colleoni, M; de Braud, F; Nelli, P; Nolè, F; Zilembo, N | 1 |
| Eliason, JF; Givel, JC; Laurent, PL; Odartchenko, N; Suardet, L; Tevaearai, HT | 1 |
| Calabresi, F; Repetto, M | 1 |
| Harada, T; Hirano, M; Kikkawa, H; Masuda, S; Matsu, T; Saito, H; Sakatoku, M; Tatsuzawa, T | 1 |
| Dobbs, BR; Edwards, IR; Perrier, DG; Schaaf, LJ | 1 |
| Hattori, T; Hirabayashi, N; Kirihara, Y; Niimoto, M; Nishiyama, M; Nosoh, Y; Saeki, T; Takagami, S | 1 |
5 review(s) available for doxifluridine and Colorectal Neoplasms
| Article | Year |
|---|---|
Oral versus intravenous fluoropyrimidines for colorectal cancer.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2017 |
[Doxifluridine for treatment of colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Pentosyltransferases; Prodrugs; Prognosis; Pyrimidine Phosphorylases; Thymidine Phosphorylase | 2003 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
[PyNPase expression and cancer progression in the colorectum].
Topics: Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Colorectal Neoplasms; Disease Progression; Floxuridine; Humans; Macrophages; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases | 1998 |
Doxifluridine in advanced colorectal cancer.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Isomerism | 1991 |
31 trial(s) available for doxifluridine and Colorectal Neoplasms
| Article | Year |
|---|---|
UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism-directed phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Polymorphism, Genetic; Survival Analysis; Time Factors; Treatment Outcome | 2013 |
Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).
Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Glomerular Filtration Rate; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors | 2013 |
[A randomized controlled trial of postoperative adjuvant chemotherapy for colorectal cancer-optimal duration of the treatment].
Topics: Adult; Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Follow-Up Studies; Humans; Middle Aged; Prospective Studies; Survival Rate; Time Factors | 2009 |
Phase I study of irinotecan and doxifluridine for metastatic colorectal cancer focusing on the UGT1A1*28 polymorphism.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Polymorphism, Genetic | 2010 |
Plasma disposition of capecitabine and its metabolites 5'DFCR and 5'DFUR in a standard and dose-intensified monotherapy regimen.
Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Cross-Over Studies; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2011 |
Hepatic arterial infusion with oxaliplatin, irinotecan and doxifluridine for unresectable liver metastases of colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoembolization, Therapeutic; Colorectal Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Iodized Oil; Irinotecan; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin | 2010 |
Factors predicting the response to oral fluoropyrimidine drugs: a phase II trial on the individualization of postoperative adjuvant chemotherapy using oral fluorinated pyrimidines in stage III colorectal cancer treated by curative resection (ACT-01 Study)
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Confidence Intervals; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Floxuridine; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Orotate Phosphoribosyltransferase; Proportional Hazards Models; RNA, Messenger; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase | 2013 |
Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase II trial with intravenous 5-fluorouracil plus leucovorin.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Survival Analysis | 2003 |
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunosuppressive Agents; Lymphatic Metastasis; Male; Middle Aged; Prognosis; Recurrence; Time Factors; Treatment Outcome | 2003 |
Gene expression profiles of colorectal carcinoma in response to neo-adjuvant chemotherapy.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Interactions; Female; Floxuridine; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoadjuvant Therapy; Treatment Outcome; Up-Regulation | 2004 |
Sequential treatment with irinotecan and doxifluridine: optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Transplantation, Heterologous | 2005 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer.
Topics: Adult; Aged; Antineoplastic Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Humans; Male; Middle Aged; Mitomycin; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases; Recurrence; Survival Analysis; Treatment Outcome | 2007 |
Doxifluridine and leucovorin: an oral treatment combination in advanced colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Gastrointestinal Diseases; Humans; Leucovorin; Male; Middle Aged; Survival Rate; Treatment Outcome | 1995 |
Oral doxifluridine in elderly patients with metastatic colorectal cancer: a multicenter phase II study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Diarrhea; Feasibility Studies; Female; Floxuridine; Humans; Italy; Male; Neoplasm Metastasis; Remission Induction | 1994 |
[Hepatic arterial infusion after hepatectomy for liver metastases of colorectal carcinoma to prevent residual hepatic recurrence].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Prognosis | 1994 |
[Adjuvant chemo-endocrine chemotherapy with gastrin antagonist after resection of liver metastasis in colorectal cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Doxorubicin; Female; Floxuridine; Gastrins; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Proglumide | 1994 |
[A study of preoperative administration of 5'-DFUR in patients with colo-rectal cancer].
Topics: Administration, Oral; Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1994 |
[Study of 5'-DFUR treatment as postoperative adjuvant chemotherapy for stomach and colorectal cancer. Tokai GATS Group (pilot study)].
Topics: Administration, Oral; Antineoplastic Agents; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diarrhea; Drug Administration Schedule; Floxuridine; Humans; Mitomycin; Pilot Projects; Postoperative Care; Remission Induction; Stomach Neoplasms; Survival Rate | 1994 |
Prospective randomised trial comparing fluorouracil versus doxifluridine for the treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leukopenia; Male; Middle Aged; Prospective Studies | 1993 |
Effect of low dose cyclophosphamide on the synthesis of acute phase protein and its significance for cancer chemotherapy.
Topics: Acute-Phase Proteins; Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cyclophosphamide; Floxuridine; Humans; Middle Aged; Neoplasm Proteins | 1996 |
Randomized phase II noncomparative trial of oral and intravenous doxifluridine plus levo-leucovorin in untreated patients with advanced colorectal carcinoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antidotes; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Survival Rate | 1996 |
Doxifluridine in colorectal cancer patients resistant to 5-fluorouracil (5-FU) containing regimens.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed | 1997 |
Results of leucovorin and doxifluridine oral regimen in the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Humans; Italy; Leucovorin; Male; Middle Aged; Treatment Outcome | 1998 |
[Antitumor effect of 5'-DFUR and PyNPase activity in colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1999 |
Selective augmentations of intratumoral 5-fluorouracil concentration by local immunotherapy with OK-432 and fibrinogen.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colon; Colorectal Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Fibrinogen; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Picibanil; Rectum | 2000 |
[Preoperative chemotherapy for advanced colorectal carcinomas--comparison of histological effect between 5'-DFUR + leucovorin tablet and 5'-DFUR alone].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Preoperative Care; Tablets | 2001 |
Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels.
Topics: Antimetabolites, Antineoplastic; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Rectum; RNA, Messenger | 2001 |
[Combination chemotherapy of doxifluridine plus mitomycin C for colorectal lung metastasis--phase II study].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Survival Rate | 2001 |
The pharmacokinetics of doxifluridine and 5-fluorouracil after single intravenous infusions of doxifluridine to patients with colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged | 1988 |
31 other study(ies) available for doxifluridine and Colorectal Neoplasms
| Article | Year |
|---|---|
Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cell Proliferation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Proton Pump Inhibitors; Rabeprazole | 2019 |
Impact of co-administered drugs on drug monitoring of capecitabine in patients with advanced colorectal cancer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Floxuridine; Fluorouracil; Humans; Pantoprazole; Proton Pump Inhibitors | 2014 |
Clinical pharmacokinetics of capecitabine and its metabolites in combination with the monoclonal antibody bevacizumab.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2014 |
[Transfection of thymidine phosphorylase cDNA with lentiviral vector enhances the anticancer effect of 5'-deoxy-5-fluorouridine on colorectal cancer cell lines HT29 and LS174T].
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Genetic Vectors; HT29 Cells; Humans; RNA, Messenger; Thymidine Phosphorylase; Transfection | 2015 |
Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.
Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Immunotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteoglycans; Retrospective Studies; Tegafur; Uracil | 2008 |
The relationship between clinicopathological factors and the reduction of pyrimidine nucleoside phosphorylase activity after preoperative administration of 5'-deoxy-5-fluorouridine.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Humans; Pentosyltransferases; Pyrimidine Phosphorylases | 2010 |
Clinical significance of microsatellite instability for stage II or III colorectal cancer following adjuvant therapy with doxifluridine.
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Cohort Studies; Colorectal Neoplasms; Female; Floxuridine; Humans; Male; Microsatellite Instability; Middle Aged; Neoplasm Staging; Young Adult | 2011 |
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil | 2012 |
[Optimal dosing schedule in combination therapy with irinotecan and doxifluridine in a human colorectal cancer xenograft model].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Floxuridine; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation | 2003 |
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prodrugs | 2003 |
[Thymidine phosphorylase expressed in monocyte-macrophages enhanced anticancer effect of 5'-deoxy-5-fluorouridine on colorectal carcinoma cells].
Topics: Adenocarcinoma; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Floxuridine; Humans; Immunohistochemistry; Macrophages; Monocytes; Thymidine Phosphorylase; U937 Cells | 2004 |
Prediction of 5'-deoxy-5-fluorouridine sensitivity in colorectal cancer cases by thymidine phosphorylase activity and preliminary identification of susceptibility related genes.
Topics: Aged; Antimetabolites, Antineoplastic; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Female; Floxuridine; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Male; Middle Aged; RNA, Messenger; Thymidine Phosphorylase | 2004 |
Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients.
Topics: Administration, Oral; Aged; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Prognosis; Risk; Thymidine Phosphorylase; Time Factors; Treatment Outcome | 2005 |
[Long-term survival in a case of large bowel cancer--efficacy of CPT-11-based chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Mitomycin; Peritoneal Neoplasms; Survivors | 2005 |
The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Retrospective Studies; Survival Rate; Tegafur; Uracil | 2006 |
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
Topics: Animals; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Humans; Liver; Mice; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Floxuridine; Humans; Male; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Retrospective Studies; Survival Rate; Tegafur; Vascular Endothelial Growth Factor A | 2006 |
[A treatment for pulmonary metastases from colorectal cancer by pre-operative CPT-11/5'-DFUR combination therapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Humans; Irinotecan; Lung Neoplasms; Middle Aged; Neoadjuvant Therapy; Pneumonectomy | 2006 |
[Study on the relationship between concentrations of 5-FU and PyNPase activity in tumor tissue during oral 5'-DFUR treatment in patients with advanced colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1994 |
[PyNPase activity in primary and metastatic colorectal cancer].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1997 |
[The relation between pyrimidine nucleoside phosphorylase (PyNPase) activity in colorectal cancer tissues and pathological effects].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Humans; Male; Middle Aged; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1997 |
[Pyrimidine nucleoside phosphorylase activity, 5-fluorouracil concentration and thymidylate synthase inhibition rate in colorectal cancer after oral administration of 5'-doxifluridine].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Thymidylate Synthase | 1997 |
[Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Doxorubicin; Drug Administration Schedule; Floxuridine; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Proglumide; Receptors, Cholecystokinin | 1998 |
[Three cases of colorectal cancer with lung metastasis successfully treated with combination chemotherapy using 5'-DFUR and MMC].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Quality of Life | 1998 |
[Comparative study of 5'-DFUR administration of single time per day versus two or three times].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Middle Aged | 1998 |
Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Cloning, Molecular; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Humans; Recombinant Proteins; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1999 |
[Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Oxidoreductases; Survival Rate; Thymidine Phosphorylase | 2001 |
Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis | 1992 |
Interactions of interferon-alpha 2a with 5'-deoxy-5-fluorouridine in colorectal cancer cells in vitro.
Topics: Antineoplastic Agents; Cell Division; Colorectal Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Thymidine Phosphorylase; Tumor Cells, Cultured | 1992 |
[A study on preoperative administration of doxifluridine in carcinoma of the colon and rectum].
Topics: Adenocarcinoma; Administration, Oral; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care | 1990 |
The antiproliferative effects of fluoropyrimidine derivatives against human tumor xenografts in a subrenal capsule assay.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Division; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Transplantation, Heterologous | 1988 |