doxepin has been researched along with Uremia in 3 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabapentin and doxepin are well-known treatments of uremic pruritus in hemodialysis patients but no head-to-head studies were conducted to date." | 9.34 | Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial. ( Ammoury, A; Bachour, J; Haber, R; Habr, L; Joubran, N; Khoury, F; Maacaron, T; Salloum, A, 2020) |
| "Pregabalin was more effective than doxepin in reducing the severity of uremic pruritus and improving the quality of life of patients in this study, so we suggest that clinician can consider pregabalin prior to using antihistamine drugs in the management of severe itch in hemodialysis patients." | 9.24 | Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( Etminan, A; Foroutan, N; Nikvarz, N; Shojai Shahrokh Abadi, M, 2017) |
| "Gabapentin and doxepin are well-known treatments of uremic pruritus in hemodialysis patients but no head-to-head studies were conducted to date." | 5.34 | Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial. ( Ammoury, A; Bachour, J; Haber, R; Habr, L; Joubran, N; Khoury, F; Maacaron, T; Salloum, A, 2020) |
| "Pregabalin was more effective than doxepin in reducing the severity of uremic pruritus and improving the quality of life of patients in this study, so we suggest that clinician can consider pregabalin prior to using antihistamine drugs in the management of severe itch in hemodialysis patients." | 5.24 | Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( Etminan, A; Foroutan, N; Nikvarz, N; Shojai Shahrokh Abadi, M, 2017) |
| " The dialysis experiments show that modification of the usual dosage regimen is not necessary during hemodialysis or on dialysis days." | 1.27 | Hemodialysis of doxepin and desmethyldoxepin in uremic patients. ( Faulkner, RD; Lee, CS; Senekjian, HO, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Haber, R | 1 |
| Bachour, J | 1 |
| Salloum, A | 1 |
| Maacaron, T | 1 |
| Khoury, F | 1 |
| Habr, L | 1 |
| Ammoury, A | 1 |
| Joubran, N | 1 |
| Foroutan, N | 1 |
| Etminan, A | 1 |
| Nikvarz, N | 1 |
| Shojai Shahrokh Abadi, M | 1 |
| Faulkner, RD | 1 |
| Senekjian, HO | 1 |
| Lee, CS | 1 |
2 trials available for doxepin and Uremia
| Article | Year |
|---|---|
Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial.
Topics: Double-Blind Method; Doxepin; Gabapentin; Histamine Antagonists; Humans; Pruritus; Quality of Life; | 2020 |
Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial.
Topics: Analgesics; Doxepin; Female; Histamine Antagonists; Humans; Male; Middle Aged; Pregabalin; Pruritus; | 2017 |
1 other study available for doxepin and Uremia
| Article | Year |
|---|---|
Hemodialysis of doxepin and desmethyldoxepin in uremic patients.
Topics: Adult; Aged; Depression; Doxepin; Half-Life; Humans; Middle Aged; Renal Dialysis; Uremia | 1984 |