doxepin has been researched along with Substance Withdrawal Syndrome in 16 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " But 2 days later he developed auditory hallucinations which were interpreted as alcohol hallucinations, for which he was additionally given haloperidol, 15 mg/d." | 3.68 | [Central anticholinergic intoxication syndrome. A contribution to the differential diagnosis of exogenous psychoses]. ( Eikmeier, G; Gastpar, M; Kastrup, O, 1991) |
| "Patients meeting DSM-IV-TR criteria for primary insomnia were randomized to 35 days of nightly treatment with DXP 3 mg (n=75), DXP 6 mg (n=73), or placebo (PBO; n=73), followed by 2 nights of single-blind PBO to evaluate discontinuation (DC) effects." | 2.76 | Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. ( Durrence, HH; Jochelson, P; Krystal, AD; Lankford, A; Ludington, E; Rogowski, R; Roth, T, 2011) |
| "Clonidine was slightly more effective in controlling sweating, hot flushes, palpitations and nausea, and doxepin was slightly more effective in relieving the craving for opiates, lassitude and depression." | 2.66 | A controlled comparison of clonidine and doxepin in the treatment of the opiate withdrawal syndrome. ( Täschner, KL, 1986) |
| " Mean administration of clonidine (on an "as-needed" basis) was 5 days (maximum 7 days), whilst the mean daily dosage ranged from 0." | 1.27 | [Clonidine for the treatment of heroin withdrawal syndrome]. ( Hermann, P; Presslich, O; Schanda, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krystal, AD | 1 |
| Lankford, A | 1 |
| Durrence, HH | 1 |
| Ludington, E | 1 |
| Jochelson, P | 1 |
| Rogowski, R | 1 |
| Roth, T | 1 |
| Schanda, H | 1 |
| Presslich, O | 1 |
| Hermann, P | 1 |
| Borg, V | 1 |
| Santos, AB | 1 |
| Mccurdy, L | 1 |
| Pary, RJ | 1 |
| Klontz, W | 1 |
| Foxworth, JM | 1 |
| Galynker, II | 1 |
| Rosenthal, RN | 1 |
| Perkel, C | 1 |
| Shwartz, A | 1 |
| Ulmer, A | 1 |
| Rosenstock, J | 1 |
| Prack, G | 1 |
| May, B | 1 |
| Kastrup, O | 1 |
| Eikmeier, G | 1 |
| Gastpar, M | 1 |
| Murphy, JK | 1 |
| Edwards, NB | 2 |
| Downs, AD | 1 |
| Ackerman, BJ | 1 |
| Rosenthal, TL | 2 |
| Fellhauer, M | 1 |
| Simmons, RC | 1 |
| Hoon, PW | 1 |
| Downs, JM | 1 |
| Täschner, KL | 1 |
| Ayd, FJ | 1 |
| Daunderer, M | 1 |
| Kerscher, M | 1 |
| Bühringer, G | 1 |
| Kaneto, H | 1 |
| Koida, M | 1 |
| Tsuchie, F | 1 |
| Miyagawa, H | 1 |
4 trials available for doxepin and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.
Topics: Adolescent; Adult; Chronic Disease; Double-Blind Method; Doxepin; Female; Humans; Hypnotics and Seda | 2011 |
[Clinical trial of Tegretol and Anafranil/Sinequan in alcohol abstinence symptoms].
Topics: Alcoholism; Carbamazepine; Clinical Trials as Topic; Clomipramine; Depression; Double-Blind Method; | 1980 |
Effects of doxepin on withdrawal symptoms in smoking cessation.
Topics: Adult; Circadian Rhythm; Clinical Trials as Topic; Data Collection; Double-Blind Method; Doxepin; Dr | 1990 |
A controlled comparison of clonidine and doxepin in the treatment of the opiate withdrawal syndrome.
Topics: Adolescent; Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Doxepin; Female; Heroin | 1986 |
12 other studies available for doxepin and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
[Clonidine for the treatment of heroin withdrawal syndrome].
Topics: 2-Hydroxyphenethylamine; Clonidine; Dose-Response Relationship, Drug; Doxepin; Drug Administration S | 1983 |
Delirium after abrupt withdrawal from doxepin: case report.
Topics: Adjustment Disorders; Adult; Delirium; Doxepin; Humans; Male; Substance Withdrawal Syndrome | 1980 |
Cholinergic rebounds and withdrawal syndromes.
Topics: Benztropine; Doxepin; Haloperidol; Humans; Male; Receptors, Cholinergic; Substance Withdrawal Syndro | 1980 |
Doxepin withdrawal mania.
Topics: Bipolar Disorder; Doxepin; Drug Therapy, Combination; Female; Humans; Lithium; Lorazepam; Middle Age | 1995 |
[Cerebral seizures under doxepin during a substitution with dihydrocodeine].
Topics: Brain Diseases; Codeine; Depression; Doxepin; Humans; Seizures; Substance Withdrawal Syndrome | 1994 |
[Therapy of drug dependence in adolescents. Clinical aspects of somatic detoxification].
Topics: Adolescent; Adult; Age Factors; Doxepin; Female; Follow-Up Studies; Humans; Male; Methadone; Piracet | 1976 |
[Central anticholinergic intoxication syndrome. A contribution to the differential diagnosis of exogenous psychoses].
Topics: Akathisia, Drug-Induced; Biperiden; Diagnosis, Differential; Doxepin; Dysarthria; Dyskinesia, Drug-I | 1991 |
[Drug treatment of nicotine dependence].
Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndro | 1990 |
Doxepin in the treatment of nicotine withdrawal.
Topics: Adult; Aged; Doxepin; Female; Humans; Middle Aged; Nicotine; Patient Compliance; Substance Withdrawa | 1988 |
Five to fifteen years' maintenance doxepin therapy.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Depressive Disorder; Doxepin; Drug Interactions; Fe | 1986 |
[Detoxication of juvenile addicts in a general hospital (author's transl)].
Topics: Adolescent; Attitude of Health Personnel; Behavior Therapy; Doxepin; Germany, West; Hospitals, Gener | 1974 |
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice].
Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight | 1973 |