doxepin has been researched along with Sleep Wake Disorders in 11 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxepin is a tricyclic compound that has been used extensively for the treatment of depressive and anxiety disorders for approximately thirty years." | 2.45 | Low-dose doxepin for the treatment of insomnia: emerging data. ( Goforth, HW, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goforth, HW | 1 |
| Kelsay, K | 1 |
| Roth, T | 1 |
| Zorick, F | 1 |
| Wittig, R | 1 |
| McLenaghan, A | 1 |
| Roehrs, T | 1 |
| Finnerty, RJ | 3 |
| Goldberg, HL | 3 |
| Rodenbeck, A | 1 |
| Huether, G | 1 |
| Rüther, E | 1 |
| Hajak, G | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Rickels, K | 1 |
| Radmayr, E | 1 |
| Mendels, J | 1 |
| Schless, A | 1 |
| Ewert, EG | 1 |
| Nathan, L | 1 |
| Cole, JO | 1 |
4 reviews available for doxepin and Sleep Wake Disorders
| Article | Year |
|---|---|
Low-dose doxepin for the treatment of insomnia: emerging data.
Topics: Antidepressive Agents, Tricyclic; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Doxep | 2009 |
Management of sleep disturbance associated with atopic dermatitis.
Topics: Algorithms; Clonidine; Dermatitis, Atopic; Doxepin; Histamine H1 Antagonists; Humans; Hypnotics and | 2006 |
Nocturnal melatonin secretion and its modification by treatment in patients with sleep disorders.
Topics: Adult; Circadian Rhythm; Doxepin; Flunitrazepam; Humans; Hypnotics and Sedatives; Melatonin; Middle | 1999 |
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression.
Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte | 1977 |
4 trials available for doxepin and Sleep Wake Disorders
| Article | Year |
|---|---|
Specific responses to imipramine and doxepin in psychoneurotic depressed patients with sleep disturbance.
Topics: Adult; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Imipramine; Male; Random A | 1981 |
Doxepin versus imipramine in psychoneurotic depressed patients with sleep disturbance: a double-blind study.
Topics: Adjustment Disorders; Adult; Aged; Anxiety; Cognition; Double-Blind Method; Doxepin; Drug Evaluation | 1978 |
A controlled comparison of doxepin h.s. and doxepin q.i.d.
Topics: Adult; Anxiety; Depression; Doxepin; Female; Humans; Male; Middle Aged; Placebos; Psychiatric Status | 1975 |
Doxepin in a single bedtime dose in psychoneurotic outpatients.
Topics: Adjustment Disorders; Administration, Oral; Adult; Ambulatory Care; Anxiety Disorders; Clinical Tria | 1974 |
3 other studies available for doxepin and Sleep Wake Disorders
| Article | Year |
|---|---|
The effects of doxepin HCl on sleep and depression.
Topics: Adult; Circadian Rhythm; Depressive Disorder; Dose-Response Relationship, Drug; Doxepin; Female; Hum | 1982 |
[Experience with Sinquan in a single bedtime dose].
Topics: Adult; Depression; Doxepin; Drug Evaluation; Female; Humans; Male; Middle Aged; Psychotic Disorders; | 1977 |
[Corticoid-induced psychovegetative disorders and their therapy using Sinquan].
Topics: Adrenal Cortex Hormones; Adult; Bipolar Disorder; Doxepin; Female; Humans; Long-Term Care; Male; Mid | 1973 |