doxepin has been researched along with Pruritus in 22 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabapentin and doxepin are well-known treatments of uremic pruritus in hemodialysis patients but no head-to-head studies were conducted to date." | 9.34 | Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial. ( Ammoury, A; Bachour, J; Haber, R; Habr, L; Joubran, N; Khoury, F; Maacaron, T; Salloum, A, 2020) |
| "Pregabalin was more effective than doxepin in reducing the severity of uremic pruritus and improving the quality of life of patients in this study, so we suggest that clinician can consider pregabalin prior to using antihistamine drugs in the management of severe itch in hemodialysis patients." | 9.24 | Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( Etminan, A; Foroutan, N; Nikvarz, N; Shojai Shahrokh Abadi, M, 2017) |
| "We suggest that doxepin, a tricyclic antidepressant with anti-H1 receptor effect, can help improve pruritus resistant to antihistamines in end-stage renal disease patients who undergo hemodialysis." | 9.12 | Low-dose doxepin for treatment of pruritus in patients on hemodialysis. ( Farrokhi, F; Firouzan, A; Nasli Esfahani, E; Nasrollahi, A; Pour-Reza-Gholi, F, 2007) |
| "A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard." | 9.12 | Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. ( Davoudi, SM; Keshavarz, S; Sadr, B; Shohrati, M; Tajik, A, 2007) |
| "The current study was undertaken to compare the efficacy and safety of topical 5% doxepin cream in relieving pruritus associated with atopic dermatitis." | 9.07 | Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group. ( Drake, LA; Fallon, JD; Sober, A, 1994) |
| "To evaluate the effect of doxepin hydrochloride 5% cream on reducing pruritus in burn scar patients compared to a placebo cream." | 5.34 | Doxepin cream is not effective in reducing itch in burn scar patients: A multicenter triple-blind randomized clinical crossover trial. ( Breederveld, RS; Kwa, KAA; Legemate, CM; Meij-de Vries, A; Middelkoop, E; Nieuwenhuis, MK; Pijpe, A; van Baar, ME, 2020) |
| "Gabapentin and doxepin are well-known treatments of uremic pruritus in hemodialysis patients but no head-to-head studies were conducted to date." | 5.34 | Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial. ( Ammoury, A; Bachour, J; Haber, R; Habr, L; Joubran, N; Khoury, F; Maacaron, T; Salloum, A, 2020) |
| "Pregabalin was more effective than doxepin in reducing the severity of uremic pruritus and improving the quality of life of patients in this study, so we suggest that clinician can consider pregabalin prior to using antihistamine drugs in the management of severe itch in hemodialysis patients." | 5.24 | Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial. ( Etminan, A; Foroutan, N; Nikvarz, N; Shojai Shahrokh Abadi, M, 2017) |
| "We suggest that doxepin, a tricyclic antidepressant with anti-H1 receptor effect, can help improve pruritus resistant to antihistamines in end-stage renal disease patients who undergo hemodialysis." | 5.12 | Low-dose doxepin for treatment of pruritus in patients on hemodialysis. ( Farrokhi, F; Firouzan, A; Nasli Esfahani, E; Nasrollahi, A; Pour-Reza-Gholi, F, 2007) |
| "A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard." | 5.12 | Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. ( Davoudi, SM; Keshavarz, S; Sadr, B; Shohrati, M; Tajik, A, 2007) |
| " Since efficient benefit on pruritus and excoriations has been demonstrated with tricyclic agents, we investigated how the topical treatment with doxepin (5%, Boehringer Standard, Mannheim, Germany), a tricyclic compound with anticholinergic properties, may influence ACH induced itch and cutaneous sensations (erythema, wheal, axonreflex flare)." | 5.09 | Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema. ( Groene, D; Heyer, G; Martus, P, 2001) |
| "The current study was undertaken to compare the efficacy and safety of topical 5% doxepin cream in relieving pruritus associated with atopic dermatitis." | 5.07 | Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group. ( Drake, LA; Fallon, JD; Sober, A, 1994) |
| "Only four large, randomized, double-blind, placebo-controlled clinical trials with definitive conclusions (grade A) support the use of topical antihistaminic agents, specifically topical doxepin, for relief of pruritus." | 4.86 | An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus. ( Eschler, DC; Klein, PA, 2010) |
| "Histamine 1% was applied to the volar forearms using skin prick-test lancets." | 2.84 | Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Hilborg, SD; Jerwiarz, A; Melholt, C; Randers, A; Simoni, A, 2017) |
| "The causes of pruritus are numerous including xerosis, drug and photoeruptions, follicular and papular eruptions as well as infestations and infections by a wide range of organisms." | 2.68 | Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation. ( Lee, RB; Skelton, HG; Smith, KJ; Wagner, KF; Yeager, J, 1997) |
| "Psoriasis is a common chronic inflammatory skin disease observed in about 1-3% of the general population." | 2.53 | Itch in Psoriasis Management. ( Reich, A; Szepietowski, JC, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Kwa, KAA | 1 |
| Legemate, CM | 1 |
| Pijpe, A | 1 |
| Meij-de Vries, A | 1 |
| Middelkoop, E | 1 |
| van Baar, ME | 1 |
| Breederveld, RS | 1 |
| Nieuwenhuis, MK | 1 |
| Queruel, P | 1 |
| Bartholomei, MN | 1 |
| Chauvineau-Mortelette, V | 1 |
| Cabaret, E | 1 |
| Bartoli, JL | 1 |
| Naville, L | 1 |
| Laveix, I | 1 |
| Arnaudo, L | 1 |
| Haber, R | 1 |
| Bachour, J | 1 |
| Salloum, A | 1 |
| Maacaron, T | 1 |
| Khoury, F | 1 |
| Habr, L | 1 |
| Ammoury, A | 1 |
| Joubran, N | 1 |
| Beck, KM | 1 |
| Yang, EJ | 1 |
| Koo, J | 1 |
| Liang, Z | 1 |
| Huang, Q | 1 |
| Zhang, LS | 1 |
| Andersen, HH | 1 |
| Melholt, C | 1 |
| Hilborg, SD | 1 |
| Jerwiarz, A | 1 |
| Randers, A | 1 |
| Simoni, A | 1 |
| Elberling, J | 1 |
| Arendt-Nielsen, L | 1 |
| Foroutan, N | 1 |
| Etminan, A | 1 |
| Nikvarz, N | 1 |
| Shojai Shahrokh Abadi, M | 1 |
| Szepietowski, JC | 1 |
| Reich, A | 1 |
| Şavk, E | 1 |
| Danarti, R | 1 |
| Waskito, F | 1 |
| Indrastuti, N | 1 |
| Pour-Reza-Gholi, F | 1 |
| Nasrollahi, A | 1 |
| Firouzan, A | 1 |
| Nasli Esfahani, E | 1 |
| Farrokhi, F | 1 |
| Eschler, DC | 1 |
| Klein, PA | 1 |
| Blum, A | 1 |
| Shohrati, M | 1 |
| Davoudi, SM | 1 |
| Keshavarz, S | 1 |
| Sadr, B | 1 |
| Tajik, A | 1 |
| Bernstein, JE | 1 |
| Whitney, DH | 1 |
| Soltani, K | 1 |
| Drake, LA | 1 |
| Fallon, JD | 1 |
| Sober, A | 1 |
| Millikan, LE | 1 |
| Shelley, WB | 1 |
| Shelley, ED | 1 |
| Talanin, NY | 1 |
| Smith, PF | 1 |
| Corelli, RL | 1 |
| Smith, KJ | 1 |
| Skelton, HG | 1 |
| Yeager, J | 1 |
| Lee, RB | 1 |
| Wagner, KF | 1 |
| Groene, D | 1 |
| Martus, P | 1 |
| Heyer, G | 1 |
4 reviews available for doxepin and Pruritus
| Article | Year |
|---|---|
Itch in Psoriasis Management.
Topics: Adaptation, Psychological; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Doxepin; | 2016 |
Neurologic Itch Management.
Topics: Acupuncture Therapy; Amines; Anesthetics, Local; Anticonvulsants; Antipruritics; Botulinum Toxins, T | 2016 |
An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus.
Topics: Administration, Cutaneous; Diphenhydramine; Doxepin; Evidence-Based Medicine; Histamine Antagonists; | 2010 |
Treating pruritus. What's new in safe relief of symptoms?
Topics: Administration, Topical; Adrenal Cortex Hormones; Antipruritics; Doxepin; Histamine H1 Antagonists; | 1996 |
11 trials available for doxepin and Pruritus
| Article | Year |
|---|---|
Doxepin cream is not effective in reducing itch in burn scar patients: A multicenter triple-blind randomized clinical crossover trial.
Topics: Administration, Cutaneous; Adult; Body Surface Area; Burns; Cicatrix; Cross-Over Studies; Double-Bli | 2020 |
Comparison of gabapentin and doxepin in the management of uremic pruritus: A randomized crossover clinical trial.
Topics: Double-Blind Method; Doxepin; Gabapentin; Histamine Antagonists; Humans; Pruritus; Quality of Life; | 2020 |
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
Topics: Acrolein; Antipruritics; Cold Temperature; Doxepin; Female; Healthy Volunteers; Histamine; Histamine | 2017 |
Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial.
Topics: Analgesics; Doxepin; Female; Histamine Antagonists; Humans; Male; Middle Aged; Pregabalin; Pruritus; | 2017 |
Onset and duration of action of topical antihistamine: a study of histamine skin test response.
Topics: Administration, Topical; Adolescent; Adult; Allergens; Cross-Over Studies; Dermatitis, Atopic; Doubl | 2008 |
Low-dose doxepin for treatment of pruritus in patients on hemodialysis.
Topics: Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Doxepin; Fem | 2007 |
Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial.
Topics: Administration, Oral; Adult; Antipruritics; Cetirizine; Chemical Warfare Agents; Chronic Disease; Do | 2007 |
Inhibition of histamine-induced pruritus by topical tricyclic antidepressants.
Topics: Administration, Topical; Amitriptyline; Antidepressive Agents, Tricyclic; Diphenhydramine; Double-Bl | 1981 |
Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group.
Topics: Administration, Cutaneous; Adult; Dermatitis, Atopic; Double-Blind Method; Doxepin; Eczema; Female; | 1994 |
Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation.
Topics: Administration, Cutaneous; Administration, Topical; Anti-Inflammatory Agents; Antipruritics; Cycloox | 1997 |
Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema.
Topics: Acetylcholine; Administration, Cutaneous; Adult; Antipruritics; Area Under Curve; Cholinergic Antago | 2001 |
7 other studies available for doxepin and Pruritus
| Article | Year |
|---|---|
Use of topical doxepin for the treatment of burn scar pruritus in adults: An inaccessible therapeutic alternative?
Topics: Administration, Cutaneous; Adult; Burns; Cicatrix; Doxepin; Drug Costs; France; Histamine Antagonist | 2020 |
Dose escalation of doxepin for intractable pruritus.
Topics: Antidepressive Agents, Tricyclic; Antipruritics; Chronic Disease; Doxepin; Humans; Pruritus | 2018 |
Pruritus in the Right Lower Limb Occurred During Removal of the Right Meningioma.
Topics: Adult; Antipruritics; Capsaicin; Doxepin; Female; Histamine Antagonists; Humans; Lower Extremity; Ma | 2016 |
Responses to article regarding a diagnostic approach to pruritus.
Topics: Doxepin; Histamine Antagonists; Humans; Pruritus | 2012 |
Doxepin cream for pruritus.
Topics: Administration, Cutaneous; Controlled Clinical Trials as Topic; Doxepin; Eczema; Histamine H1 Antago | 1994 |
Self-potentiating allergic contact dermatitis caused by doxepin hydrochloride cream.
Topics: Adult; Aged; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dermatologic Agents; Doxepin; Drug Er | 1996 |
Doxepin in the management of pruritus associated with allergic cutaneous reactions.
Topics: Antidepressive Agents, Tricyclic; Dermatitis, Contact; Doxepin; Humans; Pruritus | 1997 |