doxepin has been researched along with Parkinson Disease in 2 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sleep outcomes included insomnia scales, clinical global impression, sleep diaries and actigraphy." | 2.78 | Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study. ( Bailes, S; Creti, L; Fichten, C; Libman, E; Pelletier, A; Postuma, RB; Rios Romenets, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rios Romenets, S | 1 |
| Creti, L | 1 |
| Fichten, C | 1 |
| Bailes, S | 1 |
| Libman, E | 1 |
| Pelletier, A | 1 |
| Postuma, RB | 1 |
| Meagher, LJ | 1 |
| McKay, D | 1 |
| Herkes, GK | 1 |
| Needham, M | 1 |
1 trial available for doxepin and Parkinson Disease
| Article | Year |
|---|---|
Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study.
Topics: Actigraphy; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Cognitive Behavioral T | 2013 |
1 other study available for doxepin and Parkinson Disease
| Article | Year |
|---|---|
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |