Page last updated: 2024-10-26

doxepin and Neoplasms

doxepin has been researched along with Neoplasms in 5 studies

Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"This research expands on our prior study, in which we assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy."7.73Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy. ( Epstein, JB; Epstein, JD; Epstein, MS; Oien, H; Truelove, EL, 2006)
"To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day)."7.67Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain. ( Bier, R; Cohn, M; Cohn, ML; Machado, AF, 1988)
" In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome."4.80Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000)
"This research expands on our prior study, in which we assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy."3.73Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy. ( Epstein, JB; Epstein, JD; Epstein, MS; Oien, H; Truelove, EL, 2006)
"To provide an effective continuum of the relief of severe carcinomatous pain with minimal side reactions, we initiated treatment with piroxicam (60 to 120 mg per day) and doxepin hydrochloride (25 to 225 mg per day)."3.67Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain. ( Bier, R; Cohn, M; Cohn, ML; Machado, AF, 1988)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tukey, RH1
Strassburg, CP1
Kastrinsky, DB1
Sangodkar, J1
Zaware, N1
Izadmehr, S1
Dhawan, NS1
Narla, G1
Ohlmeyer, M1
Epstein, JB1
Epstein, JD1
Epstein, MS1
Oien, H1
Truelove, EL1
Storey, P1
Trumble, M1
Cohn, ML1
Machado, AF1
Bier, R1
Cohn, M1

Reviews

1 review available for doxepin and Neoplasms

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia;

2000

Other Studies

4 other studies available for doxepin and Neoplasms

ArticleYear
Reengineered tricyclic anti-cancer agents.
    Bioorganic & medicinal chemistry, 2015, Oct-01, Volume: 23, Issue:19

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dibenzazepines; Heterocyclic Compou

2015
Oral doxepin rinse: the analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Doxepin; Female; Humans; Male; Mid

2006
Rectal doxepin and carbamazepine therapy in patients with cancer.
    The New England journal of medicine, 1992, Oct-29, Volume: 327, Issue:18

    Topics: Administration, Rectal; Carbamazepine; Doxepin; Humans; Neoplasms

1992
Piroxicam and doxepin--an alternative to narcotic analgesics in managing advanced cancer pain.
    The Western journal of medicine, 1988, Volume: 148, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Doxepin; Drug Therapy, Combination; Female; Humans; Male; Middle Age

1988