doxepin has been researched along with Muscle Contraction in 5 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects." | 7.68 | Mechanism of action of doxepin in the treatment of chronic urticaria. ( Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990) |
| "The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects." | 3.68 | Mechanism of action of doxepin in the treatment of chronic urticaria. ( Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990) |
| "Doxepin was given at bedtime in a single 50 mg." | 2.66 | Doxepin in the treatment of female detrusor overactivity: a randomized double-blind crossover study. ( Jørgensen, L; Lose, G; Thunedborg, P, 1989) |
| "Doxepin was a competitive inhibitor of [3H]-mepyramine binding to guinea-pig cerebellar homogenates." | 1.27 | The binding of doxepin to histamine H1-receptors in guinea-pig and rat brain. ( Aceves, J; Mariscal, S; Morrison, KE; Young, JM, 1985) |
| "Doxepin was administered once daily during the first trimester (days 1-7), second trimester (days 8-14) or third trimester (days 15-21) of pregnancy, while imipramine was administered during the third trimester only." | 1.27 | Effects of prenatal exposure to tricyclic antidepressants on adrenergic responses in progeny. ( Field, FP; Simpkins, JW; Soltis, EE; Torosian, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Figueiredo, A | 1 |
| Ribeiro, CA | 1 |
| Gonçalo, M | 1 |
| Almeida, L | 1 |
| Poiares-Baptista, A | 1 |
| Teixeira, F | 1 |
| Lose, G | 1 |
| Jørgensen, L | 1 |
| Thunedborg, P | 1 |
| Aceves, J | 1 |
| Mariscal, S | 1 |
| Morrison, KE | 1 |
| Young, JM | 1 |
| Simpkins, JW | 1 |
| Field, FP | 1 |
| Torosian, G | 1 |
| Soltis, EE | 1 |
| Elonen, E | 1 |
| Mattila, MJ | 1 |
| Saarnivaara, L | 1 |
1 trial available for doxepin and Muscle Contraction
| Article | Year |
|---|---|
Doxepin in the treatment of female detrusor overactivity: a randomized double-blind crossover study.
Topics: Adult; Aged; Circadian Rhythm; Double-Blind Method; Doxepin; Female; Humans; Middle Aged; Muscle Con | 1989 |
4 other studies available for doxepin and Muscle Contraction
| Article | Year |
|---|---|
Mechanism of action of doxepin in the treatment of chronic urticaria.
Topics: Adult; Aged; Animals; Atropine; Carbachol; Chronic Disease; Dimaprit; Doxepin; Female; Gastric Juice | 1990 |
The binding of doxepin to histamine H1-receptors in guinea-pig and rat brain.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Doxepin; Female; Guinea Pigs; In Vitro Techni | 1985 |
Effects of prenatal exposure to tricyclic antidepressants on adrenergic responses in progeny.
Topics: Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Doxepin; Female; Gestational Age; Heart R | 1985 |
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits.
Topics: Amitriptyline; Animals; Antidepressive Agents; Aorta; Blood Pressure; Depression, Chemical; Dibenzoc | 1974 |