doxepin has been researched along with Hypotension, Orthostatic in 4 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To address this issue, the authors studied the cardiovascular effects of doxepin in 32 depressed patients with preexisting left ventricular impairment, ventricular arrhythmias, and/or conduction disease." | 3.68 | Is doxepin a safer tricyclic for the heart? ( Dalack, GW; Giardina, EG; Glassman, AH; Roose, SP; Walsh, BT; Woodring, S, 1991) |
| "The increased orthostatic hypotension occurred early in treatment and at low doses of imipramine." | 2.66 | Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients. ( Aldrich, J; Conolly, ME; Gerner, R; Hill, M; Jarvik, LF; Joseph, J; Linde, S; Mintz, J; Neshkes, RE; Rosen, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jarvik, LF | 2 |
| Read, SL | 1 |
| Mintz, J | 2 |
| Neshkes, RE | 2 |
| Roose, SP | 1 |
| Dalack, GW | 1 |
| Glassman, AH | 1 |
| Woodring, S | 1 |
| Walsh, BT | 1 |
| Giardina, EG | 1 |
| Schneider, LS | 1 |
| Gerner, R | 1 |
| Joseph, J | 1 |
| Linde, S | 1 |
| Aldrich, J | 1 |
| Conolly, ME | 1 |
| Rosen, R | 1 |
| Hill, M | 1 |
2 trials available for doxepin and Hypotension, Orthostatic
| Article | Year |
|---|---|
Pretreatment orthostatic hypotension in geriatric depression: predictor of response to imipramine and doxepin.
Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; H | 1983 |
Orthostatic effect of imipramine and doxepin in depressed geriatric outpatients.
Topics: Age Factors; Aged; Depressive Disorder; Double-Blind Method; Doxepin; Female; Humans; Hypotension, O | 1985 |
2 other studies available for doxepin and Hypotension, Orthostatic
| Article | Year |
|---|---|
Is doxepin a safer tricyclic for the heart?
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Depressive Disorder; Dose-Response Relationship, Drug; D | 1991 |
PSOP for response to imipramine and doxepin.
Topics: Blood Pressure; Doxepin; Humans; Hypotension, Orthostatic; Imipramine | 1985 |