doxepin and Hyperglycemia studies

Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.

Research Excerpts

Excerpt	Relevance	Reference
"Doxepin was further validated to stimulate the translocation of transcription factor HNF4α from the cytoplasm into the nucleus, where it promoted FAM3A transcription to enhance ATP synthesis, suppress gluconeogenesis, and reduce lipid deposition in hepatocytes."	5.56	Repurposing Doxepin to Ameliorate Steatosis and Hyperglycemia by Activating FAM3A Signaling Pathway. ( Chang, Y; Chen, Z; Cui, Q; Liu, X; Luo, Y; Meng, Y; Sun, L; Wang, J; Yang, J, 2020)
"Doxepin was further validated to stimulate the translocation of transcription factor HNF4α from the cytoplasm into the nucleus, where it promoted FAM3A transcription to enhance ATP synthesis, suppress gluconeogenesis, and reduce lipid deposition in hepatocytes."	1.56	Repurposing Doxepin to Ameliorate Steatosis and Hyperglycemia by Activating FAM3A Signaling Pathway. ( Chang, Y; Chen, Z; Cui, Q; Liu, X; Luo, Y; Meng, Y; Sun, L; Wang, J; Yang, J, 2020)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

doxepin and Hyperglycemia

Research Excerpts

Research

Studies (1)

Authors

Other Studies

Authors	Studies
Chen, Z	1
Liu, X	1
Luo, Y	1
Wang, J	1
Meng, Y	1
Sun, L	1
Chang, Y	1
Cui, Q	1
Yang, J	1