doxepin has been researched along with Heart Diseases in 6 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of doxepin on ventricular arrhythmias, the ECG, and left ventricular function was evaluated in 10 cardiac patients with symptoms with frequent ventricular premature depolarizations in a dose-ranging protocol." | 7.67 | Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias. ( Cooper, TB; Giardina, EG; Saroff, AL; Suckow, R, 1987) |
| "To address this issue, the authors studied the cardiovascular effects of doxepin in 32 depressed patients with preexisting left ventricular impairment, ventricular arrhythmias, and/or conduction disease." | 3.68 | Is doxepin a safer tricyclic for the heart? ( Dalack, GW; Giardina, EG; Glassman, AH; Roose, SP; Walsh, BT; Woodring, S, 1991) |
| "The effect of doxepin on ventricular arrhythmias, the ECG, and left ventricular function was evaluated in 10 cardiac patients with symptoms with frequent ventricular premature depolarizations in a dose-ranging protocol." | 3.67 | Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias. ( Cooper, TB; Giardina, EG; Saroff, AL; Suckow, R, 1987) |
| "Treatment with imipramine and doxepin, but not placebo, was associated with significant improvement (P less than 0." | 2.65 | Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. ( Barnes, RF; Caldwell, JH; Gumbrecht, G; Raskind, MA; Ritchie, JL; Veith, RC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luchins, DJ | 1 |
| Evans, L | 1 |
| Cox, J | 1 |
| Veith, RC | 1 |
| Raskind, MA | 1 |
| Caldwell, JH | 1 |
| Barnes, RF | 1 |
| Gumbrecht, G | 1 |
| Ritchie, JL | 1 |
| Ross, WD | 1 |
| Roose, SP | 1 |
| Dalack, GW | 1 |
| Glassman, AH | 1 |
| Woodring, S | 1 |
| Walsh, BT | 1 |
| Giardina, EG | 2 |
| Cooper, TB | 1 |
| Suckow, R | 1 |
| Saroff, AL | 1 |
1 review available for doxepin and Heart Diseases
| Article | Year |
|---|---|
Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Syst | 1983 |
2 trials available for doxepin and Heart Diseases
| Article | Year |
|---|---|
A comparative study of the therapeutic effect and cardiotoxicity of dothiepin HCl and doxepin HCl in reactive depression.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Clinical Trials as Topic; Dibenzothiepins; Dothiepin; | 1981 |
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease | 1982 |
3 other studies available for doxepin and Heart Diseases
| Article | Year |
|---|---|
Treating depressed cardiac patients.
Topics: Adjustment Disorders; Antidepressive Agents; Doxepin; Heart Diseases; Humans | 1977 |
Is doxepin a safer tricyclic for the heart?
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Depressive Disorder; Dose-Response Relationship, Drug; D | 1991 |
Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Doxepin; Drug Evaluation; Electrocardiography; Female; Heart Dise | 1987 |