doxepin has been researched along with Duodenal Ulcer in 12 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Duodenal Ulcer: A PEPTIC ULCER located in the DUODENUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the effect of 50- or 100-mg doses of oral doxepin or a placebo on basal gastric acid secretion, salivary flow, and pulse rate in seven asymptomatic patients with chronic duodenal ulcer disease." | 9.06 | Effect of doxepin on basal gastric acid and salivary secretion in patients with duodenal ulcer. ( Barnett, CC; Brater, DC; Brown-Cartwright, D; Richardson, CT, 1986) |
| "In the double-blind study of 51 patients with duodenal ulcer the effect of doxepin and placebo was evaluated." | 9.05 | Doxepin in the treatment of duodenal ulcer. A double-blind clinical study comparing doxepin and placebo. ( Andersen, OK; Bergsåker-Aspøy, J; Giercksky, KE; Halvorsen, L, 1984) |
| "In an open clinical endoscopic study, 50 patients with duodenal ulcer showed no significant difference in ulcer healing during a 6-week treatment period with doxepin HCl (50 mg h." | 9.05 | Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study. ( Hoff, GS; Holter, O; Ruud, TE; Tonder, M, 1982) |
| "Twenty-one patients with endoscopically proven active duodenal ulcers were studied in a double-blind randomized trial comparing doxepin hydrochloride (50 mg during the first week, and 100 mg thereafter, at bedtime) and cimetidine (1,200 mg/day in four divided doses)." | 9.05 | Doxepin and cimetidine in the treatment of duodenal ulcer: a double-blind comparative study. ( Shah, BK; Shrivastava, RK; Siegal, H, 1985) |
| "Ten patients with endoscopically proven active duodenal ulcers completed a double-blind placebo-controlled trial of doxepin hydrochloride." | 9.05 | Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine. ( Dayican, G; Lawlor, R; Shah, BK; Shrivastava, RK; Siegal, H, 1985) |
| "We compared the effect of 50- or 100-mg doses of oral doxepin or a placebo on basal gastric acid secretion, salivary flow, and pulse rate in seven asymptomatic patients with chronic duodenal ulcer disease." | 5.06 | Effect of doxepin on basal gastric acid and salivary secretion in patients with duodenal ulcer. ( Barnett, CC; Brater, DC; Brown-Cartwright, D; Richardson, CT, 1986) |
| "In the double-blind study of 51 patients with duodenal ulcer the effect of doxepin and placebo was evaluated." | 5.05 | Doxepin in the treatment of duodenal ulcer. A double-blind clinical study comparing doxepin and placebo. ( Andersen, OK; Bergsåker-Aspøy, J; Giercksky, KE; Halvorsen, L, 1984) |
| "In an open clinical endoscopic study, 50 patients with duodenal ulcer showed no significant difference in ulcer healing during a 6-week treatment period with doxepin HCl (50 mg h." | 5.05 | Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study. ( Hoff, GS; Holter, O; Ruud, TE; Tonder, M, 1982) |
| "Twenty-one patients with endoscopically proven active duodenal ulcers were studied in a double-blind randomized trial comparing doxepin hydrochloride (50 mg during the first week, and 100 mg thereafter, at bedtime) and cimetidine (1,200 mg/day in four divided doses)." | 5.05 | Doxepin and cimetidine in the treatment of duodenal ulcer: a double-blind comparative study. ( Shah, BK; Shrivastava, RK; Siegal, H, 1985) |
| "Ten patients with endoscopically proven active duodenal ulcers completed a double-blind placebo-controlled trial of doxepin hydrochloride." | 5.05 | Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine. ( Dayican, G; Lawlor, R; Shah, BK; Shrivastava, RK; Siegal, H, 1985) |
| "The anti-ulcer and antisecretory properties of 3-(dibenz[b,e] oxepin - 11(6H)-ylidene)-N,N- dimethylpropylamine hydrochloride (doxepin) were investigated in a series of acute experiments in rats with gastric and duodenal ulcer." | 3.67 | Anti-ulcer and secretion-inhibitory properties of the tricyclic derivative doxepin in rats and dogs. ( Fleissig, W; Leitold, M; Merk, A, 1984) |
| "Doxepin hydrochloride was given to 12 patients with duodenal ulcer and one patient with an anastomotic ulcer." | 3.66 | Tricyclic antidepressants in the treatment of peptic ulcer disease. ( Mangla, JC; Pereira, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ries, RK | 1 |
| Gilbert, DA | 1 |
| Katon, W | 1 |
| Andersen, OK | 1 |
| Bergsåker-Aspøy, J | 1 |
| Halvorsen, L | 1 |
| Giercksky, KE | 1 |
| Leitold, M | 1 |
| Fleissig, W | 1 |
| Merk, A | 1 |
| Chojnacki, J | 1 |
| Tkaczewski, W | 1 |
| Klupińska, G | 1 |
| Grzegorczyk, K | 1 |
| Michowicz, A | 1 |
| Hoff, GS | 2 |
| Ruud, TE | 2 |
| Tønder, M | 1 |
| Holter, O | 2 |
| Mangla, JC | 1 |
| Pereira, M | 1 |
| Tonder, M | 1 |
| Fauchald, NK | 1 |
| Yang, ZX | 1 |
| Tian, XL | 1 |
| Bian, ZF | 1 |
| Shrivastava, RK | 2 |
| Shah, BK | 2 |
| Siegal, H | 2 |
| Lawlor, R | 1 |
| Dayican, G | 1 |
| Brown-Cartwright, D | 1 |
| Brater, DC | 1 |
| Barnett, CC | 1 |
| Richardson, CT | 1 |
1 review available for doxepin and Duodenal Ulcer
| Article | Year |
|---|---|
Tricyclic antidepressant therapy for peptic ulcer disease.
Topics: Cimetidine; Dibenzazepines; Doxepin; Drug Administration Schedule; Drug Evaluation; Duodenal Ulcer; | 1984 |
8 trials available for doxepin and Duodenal Ulcer
| Article | Year |
|---|---|
Doxepin in the treatment of duodenal ulcer. A double-blind clinical study comparing doxepin and placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Doxepin; Duodenal Ulcer; Female; Humans; | 1984 |
Doxepin in the treatment of duodenal ulcer. An open clinical and endoscopic study comparing doxepin and cimetidine.
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Doxepin; Duodenal Ulcer; Duodenoscopy; Female; Gu | 1981 |
Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study.
Topics: Adult; Aged; Cimetidine; Doxepin; Duodenal Ulcer; Duodenoscopy; Gastric Acid; Guanidines; Humans; Mi | 1982 |
[Doxepin (Sinequan) in the treatment of dyspepsia in the upper gastrointestinal tract].
Topics: Clinical Trials as Topic; Doxepin; Duodenal Ulcer; Dyspepsia; Humans | 1976 |
[Short-term clinical trial of China made doxepin in peptic ulcer].
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Doxepin; Duodenal Ulcer; Female; Humans; Male; | 1988 |
Doxepin and cimetidine in the treatment of duodenal ulcer: a double-blind comparative study.
Topics: Adult; Aged; Anxiety; Cimetidine; Clinical Trials as Topic; Depression; Double-Blind Method; Doxepin | 1985 |
Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine.
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Doxepin; Duodenal Ulcer; Fem | 1985 |
Effect of doxepin on basal gastric acid and salivary secretion in patients with duodenal ulcer.
Topics: Adult; Aged; Doxepin; Duodenal Ulcer; Gastric Acid; Humans; Middle Aged; Pulse; Random Allocation; S | 1986 |
3 other studies available for doxepin and Duodenal Ulcer
| Article | Year |
|---|---|
Anti-ulcer and secretion-inhibitory properties of the tricyclic derivative doxepin in rats and dogs.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Benzodiazepinones; Carbachol; Cimetidine; Depr | 1984 |
[Prevention of duodenal ulcer recurrences after treatment with cimetidine preparations].
Topics: Adolescent; Adult; Chlordiazepoxide; Cimetidine; Double-Blind Method; Doxepin; Drug Combinations; Du | 1982 |
Tricyclic antidepressants in the treatment of peptic ulcer disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cimetidine; Doxepin; Duodenal Ulcer; Female; Histamin | 1982 |