doxepin has been researched along with Disease Models, Animal in 4 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The von Frey and Hargreaves' tests were used to assess mechanical allodynia and thermal hyperalgesia, respectively, after intraplantar (ipl) or subcutaneous (sc) administration of amitriptyline, doxepin, or venlafaxine, or their ipl co-administration with morphine on day 12-16 after injury." | 3.80 | Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. ( Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J, 2014) |
| "Menopause is a period of higher depressive vulnerability." | 1.43 | Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice. ( Huang, S; Liu, C; Liu, X; Ye, Y, 2016) |
| " Unexpectedly, chronic administration of doxepin or amitriptyline for 12 days produced allodynia and hyperalgesia in naïve mice." | 1.42 | Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model. ( Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M, 2015) |
| "Allodynia and hyperalgesia were assessed after intraperitoneal administration of each drug alone or in combination." | 1.35 | Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. ( Obara, I; Przewlocka, B; Wordliczek, J; Wrzosek, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jagla, G | 1 |
| Mika, J | 2 |
| Makuch, W | 2 |
| Obara, I | 2 |
| Wordliczek, J | 2 |
| Przewlocka, B | 3 |
| Jurga, AM | 1 |
| Starnowska, J | 1 |
| Wasylewski, M | 1 |
| Rojewska, E | 1 |
| Kwiatkowski, K | 1 |
| Malek, N | 1 |
| Ye, Y | 1 |
| Liu, C | 1 |
| Liu, X | 1 |
| Huang, S | 1 |
| Wrzosek, A | 1 |
4 other studies available for doxepin and Disease Models, Animal
| Article | Year |
|---|---|
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Do | 2014 |
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; | 2015 |
Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Doxepin; Estro | 2016 |
Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyc | 2009 |