doxepin has been researched along with Colonic Inertia in 2 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Colonic Inertia: Symptom characterized by the passage of stool once a week or less.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A significant positive correlation was obtained between dosage and blood levels of maprotiline and doxepin, but there was no correlation between blood levels and clinical response." | 2.65 | Therapeutic superiority of maprotiline versus doxepin in geriatric depression. ( Ahles, S; DeMet, E; Gwirtsman, HE; Halaris, A; Hill, MA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwirtsman, HE | 1 |
| Ahles, S | 1 |
| Halaris, A | 1 |
| DeMet, E | 1 |
| Hill, MA | 1 |
| Hekimian, LJ | 1 |
| Weise, CC | 1 |
| Friedhoff, AJ | 1 |
2 trials available for doxepin and Colonic Inertia
| Article | Year |
|---|---|
Therapeutic superiority of maprotiline versus doxepin in geriatric depression.
Topics: Anthracenes; Clinical Trials as Topic; Constipation; Depressive Disorder; Dizziness; Double-Blind Me | 1983 |
Onset of action of amoxapine and doxepin in outpatients with "mixed anxiety/depression".
Topics: Adult; Ambulatory Care; Amoxapine; Anxiety Disorders; Constipation; Depressive Disorder; Dibenzoxaze | 1983 |