doxepin has been researched along with Chronic Illness in 37 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard." | 9.12 | Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. ( Davoudi, SM; Keshavarz, S; Sadr, B; Shohrati, M; Tajik, A, 2007) |
| "Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent." | 9.09 | Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. ( McCleane, G, 2000) |
| "Thirty patients with chronic low back or cervical pain combined with clinical depression were studied in a six-week, randomized, double-blind comparison of doxepin and placebo." | 9.05 | Doxepin effects on chronic pain, depression and plasma opioids. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR, 1982) |
| "Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo." | 9.05 | Doxepin's effects on chronic pain and depression: a controlled study. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Lerman, JC; Neuman, CP; Watts, KS; Weiss, JL; Womble, JR, 1984) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 9.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| "Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)." | 9.05 | Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985) |
| "The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects." | 7.68 | Mechanism of action of doxepin in the treatment of chronic urticaria. ( Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990) |
| "A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard." | 5.12 | Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. ( Davoudi, SM; Keshavarz, S; Sadr, B; Shohrati, M; Tajik, A, 2007) |
| "Overall pain was significantly reduced by doxepin, capsaicin and doxepin/capsaicin to a similar extent." | 5.09 | Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. ( McCleane, G, 2000) |
| "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin." | 5.06 | Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986) |
| "Thirty patients with chronic low back or cervical pain combined with clinical depression were studied in a six-week, randomized, double-blind comparison of doxepin and placebo." | 5.05 | Doxepin effects on chronic pain, depression and plasma opioids. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR, 1982) |
| "Sixty patients with chronic pain of the low back or cervical spine concomitant with clinical depression were studied in a 6-week, randomized, double-blind comparison of doxepin and placebo." | 5.05 | Doxepin's effects on chronic pain and depression: a controlled study. ( Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Lerman, JC; Neuman, CP; Watts, KS; Weiss, JL; Womble, JR, 1984) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 5.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| "Fifty patients with chronic idiopathic urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day)." | 5.05 | Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. ( Greene, SL; Reed, CE; Schroeter, AL, 1985) |
| "The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes." | 4.79 | A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996) |
| "The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects." | 3.68 | Mechanism of action of doxepin in the treatment of chronic urticaria. ( Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990) |
| "A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin." | 3.66 | The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression. ( Bloom, VL; Friedel, RO; Ward, NG, 1979) |
| "In elderly adults with insomnia, DXP 6 mg produced significant improvements in sleep maintenance, sleep duration, and sleep quality endpoints that were sustained throughout the trial." | 2.77 | Efficacy and safety of doxepin 6 mg in a four-week outpatient trial of elderly adults with chronic primary insomnia. ( Essink, B; Heith Durrence, H; Lankford, A; Ludington, E; Rogowski, R; Roth, T, 2012) |
| "Patients meeting DSM-IV-TR criteria for primary insomnia were randomized to 35 days of nightly treatment with DXP 3 mg (n=75), DXP 6 mg (n=73), or placebo (PBO; n=73), followed by 2 nights of single-blind PBO to evaluate discontinuation (DC) effects." | 2.76 | Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. ( Durrence, HH; Jochelson, P; Krystal, AD; Lankford, A; Ludington, E; Rogowski, R; Roth, T, 2011) |
| " These improvements were not accompanied by evidence of next-day residual sedation or other significant adverse effects." | 2.75 | Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. ( Durrence, HH; Jochelson, P; Krystal, AD; Ludington, E; Rogowski, R; Roth, T; Scharf, M, 2010) |
| " Safety analyses included measures of residual sedation and adverse events." | 2.73 | Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in adults with primary insomnia. ( Corser, B; Hull, S; Koshorek, G; Lankford, A; Rogowski, R; Roth, T; Schwartz, H; Seiden, D, 2007) |
| "Treatment with imipramine and doxepin, but not placebo, was associated with significant improvement (P less than 0." | 2.65 | Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. ( Barnes, RF; Caldwell, JH; Gumbrecht, G; Raskind, MA; Ritchie, JL; Veith, RC, 1982) |
| " Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication." | 1.27 | Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (56.76) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 5 (13.51) | 29.6817 |
| 2010's | 7 (18.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, KM | 1 |
| Yang, EJ | 1 |
| Koo, J | 1 |
| Krystal, AD | 2 |
| Durrence, HH | 2 |
| Scharf, M | 1 |
| Jochelson, P | 2 |
| Rogowski, R | 4 |
| Ludington, E | 3 |
| Roth, T | 4 |
| Tarbox, JA | 1 |
| Gutta, RC | 1 |
| Radojicic, C | 1 |
| Lang, DM | 1 |
| Lankford, A | 3 |
| Essink, B | 1 |
| Heith Durrence, H | 1 |
| Zazzali, JL | 1 |
| Broder, MS | 1 |
| Chang, E | 1 |
| Chiu, MW | 1 |
| Hogan, DJ | 1 |
| Patel, S | 1 |
| Sindher, S | 1 |
| Jariwala, S | 1 |
| Hudes, G | 1 |
| Härtter, S | 1 |
| Connemann, B | 1 |
| Schönfeldt-Lecuona, C | 1 |
| Sachse, J | 1 |
| Hiemke, C | 1 |
| Shohrati, M | 1 |
| Davoudi, SM | 1 |
| Keshavarz, S | 1 |
| Sadr, B | 1 |
| Tajik, A | 1 |
| Hull, S | 1 |
| Schwartz, H | 1 |
| Koshorek, G | 1 |
| Corser, B | 1 |
| Seiden, D | 1 |
| Hameroff, SR | 3 |
| Cork, RC | 2 |
| Scherer, K | 1 |
| Crago, BR | 2 |
| Neuman, C | 1 |
| Womble, JR | 2 |
| Davis, TP | 3 |
| Richelson, E | 1 |
| Weiss, JL | 1 |
| Lerman, JC | 1 |
| Watts, KS | 1 |
| Neuman, CP | 1 |
| Ward, N | 1 |
| Bokan, JA | 1 |
| Phillips, M | 1 |
| Benedetti, C | 1 |
| Butler, S | 1 |
| Spengler, D | 1 |
| Ayd, FJ | 3 |
| Veggeberg, SK | 1 |
| Watts, KL | 1 |
| Veith, RC | 1 |
| Raskind, MA | 1 |
| Caldwell, JH | 1 |
| Barnes, RF | 1 |
| Gumbrecht, G | 1 |
| Ritchie, JL | 1 |
| Aronoff, GM | 1 |
| Evans, WO | 1 |
| Gartrell, N | 1 |
| Mosbacher, D | 1 |
| Ostrov, MR | 1 |
| Godfrey, RG | 1 |
| Kiefer, G | 1 |
| Fischer, W | 1 |
| Feuerstein, TJ | 1 |
| McCleane, G | 1 |
| Hajak, G | 1 |
| Rodenbeck, A | 1 |
| Voderholzer, U | 1 |
| Riemann, D | 1 |
| Cohrs, S | 1 |
| Hohagen, F | 1 |
| Berger, M | 1 |
| Rüther, E | 1 |
| Ward, NG | 2 |
| Bloom, VL | 1 |
| Friedel, RO | 1 |
| Ananth, J | 1 |
| Solyom, L | 1 |
| Solyom, C | 1 |
| Sookm, D | 1 |
| Figueiredo, A | 1 |
| Ribeiro, CA | 1 |
| Gonçalo, M | 1 |
| Almeida, L | 1 |
| Poiares-Baptista, A | 1 |
| Teixeira, F | 1 |
| Harto, A | 1 |
| Sendagorta, E | 1 |
| Ledo, A | 1 |
| Tollison, CD | 1 |
| Kriegel, ML | 1 |
| Harris, BA | 1 |
| Sherertz, EF | 1 |
| Flowers, FP | 1 |
| Cunha, UV | 1 |
| Callies, AL | 1 |
| Popkin, MK | 1 |
| Greene, SL | 1 |
| Reed, CE | 1 |
| Schroeter, AL | 1 |
| Harris, SJ | 1 |
| Parent, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Internet-Enhanced Management of Fibromyalgia[NCT00423631] | 118 participants (Actual) | Interventional | 2006-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for doxepin and Chronic Illness
| Article | Year |
|---|---|
The use of tricyclic antidepressants in chronic gastrointestinal pain.
Topics: Abdomen; Antidepressive Agents, Tricyclic; Chronic Disease; Cimetidine; Doxepin; Humans; Pain; Pepti | 1982 |
Doxepin as an adjunct in the treatment of chronic pain.
Topics: Chronic Disease; Clinical Trials as Topic; Depression; Depressive Disorder; Doxepin; Humans; Hydroxy | 1982 |
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif | 1996 |
17 trials available for doxepin and Chronic Illness
| Article | Year |
|---|---|
Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia.
Topics: Aged; Antidepressive Agents, Tricyclic; Chronic Disease; Dose-Response Relationship, Drug; Double-Bl | 2010 |
Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia.
Topics: Adolescent; Adult; Chronic Disease; Double-Blind Method; Doxepin; Female; Humans; Hypnotics and Seda | 2011 |
Efficacy and safety of doxepin 6 mg in a four-week outpatient trial of elderly adults with chronic primary insomnia.
Topics: Aged; Aged, 80 and over; Chronic Disease; Doxepin; Female; Histamine H1 Antagonists; Humans; Male; M | 2012 |
Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial.
Topics: Administration, Oral; Adult; Antipruritics; Cetirizine; Chemical Warfare Agents; Chronic Disease; Do | 2007 |
Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in adults with primary insomnia.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Chronic Disease; Cross-Over Studies; Double-Bli | 2007 |
Doxepin effects on chronic pain, depression and plasma opioids.
Topics: Adult; Aged; beta-Endorphin; Chronic Disease; Depression; Double-Blind Method; Doxepin; Endorphins; | 1982 |
Doxepin's effects on chronic pain and depression: a controlled study.
Topics: beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; | 1984 |
Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared.
Topics: Adult; Anxiety Disorders; Back Pain; beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depr | 1984 |
Long-term treatment of chronic depression: 15-year experience with doxepin HCl.
Topics: Adult; Aged; Ambulatory Care; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Doxepi | 1984 |
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease | 1982 |
Doxepin as an adjunct in the treatment of chronic pain.
Topics: Chronic Disease; Clinical Trials as Topic; Depression; Depressive Disorder; Doxepin; Humans; Hydroxy | 1982 |
Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adult; Antidepressive Agents, Tricyclic; Capsaicin; Chronic Disease; Double | 2000 |
Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study.
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Me | 2001 |
Doxepin in the treatment of obsessive compulsive neurosis.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Chronic Disease; Clinical Trials as Topic; Doxepin; Drug E | 1975 |
Doxepin in the treatment of chronic urticaria.
Topics: Adolescent; Adult; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Doxepin; Female; | 1985 |
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl | 1986 |
Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria.
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Autoantibodies; Blood Sedimentation; Child; Chroni | 1985 |
18 other studies available for doxepin and Chronic Illness
| Article | Year |
|---|---|
Dose escalation of doxepin for intractable pruritus.
Topics: Antidepressive Agents, Tricyclic; Antipruritics; Chronic Disease; Doxepin; Humans; Pruritus | 2018 |
Utility of routine laboratory testing in management of chronic urticaria/angioedema.
Topics: Adult; Angioedema; Blood Cell Count; Chronic Disease; Diagnostic Tests, Routine; Doxepin; Female; Hi | 2011 |
Cost, utilization, and patterns of medication use associated with chronic idiopathic urticaria.
Topics: Acetates; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Angioedema; Chronic Dise | 2012 |
Chronic urticaria with monoclonal IgG gammopathy: a clinical variant of Schnitzler syndrome?
Topics: Adult; Arthralgia; Chronic Disease; Diagnosis, Differential; Doxepin; Female; Fever; Histamine Antag | 2012 |
Elevated quetiapine serum concentrations in a patient treated concomitantly with doxepin, lorazepam, and pantoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agen | 2004 |
Sensitive and quantitative determination of plasma doxepin and desmethyldoxepin in chronic pain patients by gas chromatography and mass spectrometry.
Topics: Chronic Disease; Double-Blind Method; Doxepin; Drug Evaluation; Gas Chromatography-Mass Spectrometry | 1983 |
A case report of irritable bowel syndrome treated with doxepin.
Topics: Adult; Chronic Disease; Colonic Diseases, Functional; Doxepin; Female; Follow-Up Studies; Humans | 1982 |
Dramatic resolution of chronic urticaria.
Topics: Abscess; Adult; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin | 1995 |
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic A | 1999 |
The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression.
Topics: Chronic Disease; Depression; Doxepin; Headache; Humans; Pain; Placebos | 1979 |
Maintenance doxepin (sinequan) therapy for depressive illness.
Topics: Adult; Aged; Bipolar Disorder; Chemical and Drug Induced Liver Injury; Chronic Disease; Depression; | 1975 |
Mechanism of action of doxepin in the treatment of chronic urticaria.
Topics: Adult; Aged; Animals; Atropine; Carbachol; Chronic Disease; Dimaprit; Doxepin; Female; Gastric Juice | 1990 |
Selected tricyclic antidepressants in the management of chronic benign pain.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Doxepin; Huma | 1988 |
Five to fifteen years' maintenance doxepin therapy.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Depressive Disorder; Doxepin; Drug Interactions; Fe | 1986 |
Improvement of chronic neurotic excoriations with oral doxepin therapy.
Topics: Administration, Oral; Aged; Chronic Disease; Depression; Dermatitis, Atopic; Doxepin; Female; Humans | 1987 |
Antidepressants: their uses in nonpsychiatric disorders of aging.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr | 1986 |
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di | 1987 |
Patient with chronic and apparently treatment-resistant dysthymia.
Topics: Adult; Amoxapine; Antidepressive Agents; Chronic Disease; Depressive Disorder; Doxepin; Humans; Male | 1986 |