doxepin has been researched along with Chemical Dependence in 16 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dox concentration measured from two cases was well within a concentration range considered therapeutic, whereas subtherapeutic dosing may have occurred in another two cases." | 1.35 | Doxepin and nordoxepin concentrations in body fluids and tissues in doxepin associated deaths. ( Dettling, A; Gronewold, A; Haffner, HT; Skopp, G, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spurling, B | 1 |
| Clark, L | 1 |
| Fusick, AJ | 1 |
| Whiting, WL | 1 |
| Gronewold, A | 1 |
| Dettling, A | 1 |
| Haffner, HT | 1 |
| Skopp, G | 1 |
| Sudoh, Y | 1 |
| Cahoon, EE | 1 |
| Gerner, P | 1 |
| Wang, GK | 1 |
| Rademacher, S | 1 |
| Dietz, R | 1 |
| Haverkamp, W | 1 |
| Amitai, Y | 1 |
| Frischer, H | 1 |
| Cohen, ES | 1 |
| Holman, RC | 1 |
| Donhowe, SP | 1 |
| Vasiliades, J | 2 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Sahawneh, TM | 1 |
| Owens, C | 1 |
| Petit, JM | 1 |
| Biggs, JT | 1 |
| Burrows, GD | 1 |
| Vohra, J | 1 |
| Hunt, D | 1 |
| Sloman, JG | 1 |
| Scoggins, BA | 1 |
| Davies, B | 1 |
| Rosenstock, J | 1 |
| Prack, G | 1 |
| May, B | 1 |
| Haggerty, JJ | 1 |
| Drossman, DA | 1 |
| Daunderer, M | 1 |
| Kerscher, M | 1 |
| Bühringer, G | 1 |
| Kaneto, H | 1 |
| Koida, M | 1 |
| Tsuchie, F | 1 |
| Miyagawa, H | 1 |
2 reviews available for doxepin and Chemical Dependence
| Article | Year |
|---|---|
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression.
Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte | 1977 |
Use of psychotropic drugs in patients with peptic ulcer.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Cimetidine; Doxepin; Drug Interact | 1985 |
14 other studies available for doxepin and Chemical Dependence
| Article | Year |
|---|---|
Doxepin: Misuse and Abuse.
Topics: Antidepressive Agents, Tricyclic; Doxepin; Humans; Male; Middle Aged; Prescription Drug Misuse; Subs | 2018 |
Doxepin and nordoxepin concentrations in body fluids and tissues in doxepin associated deaths.
Topics: Adult; Antidepressive Agents, Tricyclic; Bile; Brain Chemistry; Chromatography, Liquid; Doxepin; Fem | 2009 |
Tricyclic antidepressants as long-acting local anesthetics.
Topics: Amines; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cell Line; Dose-Response Rela | 2003 |
QT prolongation and syncope with methadone, doxepin, and a beta-blocker.
Topics: Adrenergic beta-Antagonists; Adult; Anxiety Disorders; Doxepin; Electrocardiography; Humans; Long QT | 2005 |
Excess fatality from desipramine in children and adolescents.
Topics: Adolescent; Amitriptyline; Child; Desipramine; Doxepin; Humans; Imipramine; Incidence; Mortality; No | 2006 |
An integrated approach to iatrogenic drug abuse in a closed delivery system.
Topics: Adult; Aged; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Doxepin; Drug and Narcotic Control; Dr | 1980 |
Bilateral internuclear ophthalmoplegia from doxepin overdose.
Topics: Doxepin; Female; Humans; Middle Aged; Ophthalmoplegia; Substance-Related Disorders | 1984 |
Identification of misused drugs in the clinical laboratory. I. Tricyclics.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Chromatography, Thin La | 1980 |
Determination of therapeutic and toxic concentrations of doxepin and loxapine using gas-liquid chromatography with a nitrogen-sensitive detector, and gas chromatography-mass spectrometry of loxapine.
Topics: Adult; Chromatography, Gas; Dibenzoxazepines; Doxepin; Gas Chromatography-Mass Spectrometry; Humans; | 1979 |
Tricyclic antidepressant overdoses in adolescent patients.
Topics: Adolescent; Affective Symptoms; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-R | 1977 |
Cardiac effects of different tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bundle of His; Doxepin; Electrocardiograph | 1976 |
[Therapy of drug dependence in adolescents. Clinical aspects of somatic detoxification].
Topics: Adolescent; Adult; Age Factors; Doxepin; Female; Follow-Up Studies; Humans; Male; Methadone; Piracet | 1976 |
[Detoxication of juvenile addicts in a general hospital (author's transl)].
Topics: Adolescent; Attitude of Health Personnel; Behavior Therapy; Doxepin; Germany, West; Hospitals, Gener | 1974 |
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice].
Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight | 1973 |