doxepin has been researched along with Brain Neoplasms in 3 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found the treatment of C6-glioma cells with LPS results in deleterious effects, including the augmentation of inflammatory cytokine levels (tumor necrosis factor-α, interleukin-1β), and suppresses the Akt phosphorylation." | 5.56 | Anti-inflammatory effects of doxepin hydrochloride against LPS-induced C6-glioma cell inflammatory reaction by PI3K-mediated Akt signaling. ( Bo, J; Duan, L; Tao, F; Wu, J; Yao, K; Zhang, J; Zhu, J; Zu, H, 2020) |
| "We found the treatment of C6-glioma cells with LPS results in deleterious effects, including the augmentation of inflammatory cytokine levels (tumor necrosis factor-α, interleukin-1β), and suppresses the Akt phosphorylation." | 1.56 | Anti-inflammatory effects of doxepin hydrochloride against LPS-induced C6-glioma cell inflammatory reaction by PI3K-mediated Akt signaling. ( Bo, J; Duan, L; Tao, F; Wu, J; Yao, K; Zhang, J; Zhu, J; Zu, H, 2020) |
| "In this investigation the effects of tricyclic drugs on cellular respiration were studied using the anaplastic astrocytoma cell line IPSB-18 by use of a Clark-type oxygen electrode which measured changes in cellular respiration rate (oxygen consumption), in a dose-response assay." | 1.36 | The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma. ( Higgins, SC; Pilkington, GJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Tao, F | 1 |
| Zhu, J | 1 |
| Duan, L | 1 |
| Wu, J | 1 |
| Zhang, J | 1 |
| Yao, K | 1 |
| Bo, J | 1 |
| Zu, H | 1 |
| Higgins, SC | 1 |
| Pilkington, GJ | 1 |
| Koval'chuk, VV | 1 |
1 trial available for doxepin and Brain Neoplasms
| Article | Year |
|---|---|
[Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors].
Topics: Adult; Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain Neoplas | 2007 |
2 other studies available for doxepin and Brain Neoplasms
| Article | Year |
|---|---|
Anti-inflammatory effects of doxepin hydrochloride against LPS-induced C6-glioma cell inflammatory reaction by PI3K-mediated Akt signaling.
Topics: Animals; Anti-Inflammatory Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Doxepin; Glioma | 2020 |
The in vitro effects of tricyclic drugs and dexamethasone on cellular respiration of malignant glioma.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Hormonal; Antineoplastic Com | 2010 |