Page last updated: 2024-10-26

doxepin and Arrhythmia

doxepin has been researched along with Arrhythmia in 18 studies

Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.

Research Excerpts

ExcerptRelevanceReference
"The effect of doxepin on ventricular arrhythmias, the ECG, and left ventricular function was evaluated in 10 cardiac patients with symptoms with frequent ventricular premature depolarizations in a dose-ranging protocol."7.67Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias. ( Cooper, TB; Giardina, EG; Saroff, AL; Suckow, R, 1987)
"A case is described of ventricular arrhythmias associated with doxepin and amitriptyline treatment in a patient with preexisting heart disease."7.66Ventricular arrhythmias induced by doxepin and amitriptyline: case report. ( Faber, R; Todd, RD, 1983)
"This work was aimed at clarifying whether the anti-depressant doxepin had a cardiodepressant action, or favoured or initiated arrhythmias and/or ventricular conduction disorders, when administered orally for 14 days at a daily dosage of 75 mg."5.04[The influence of doxepin on the efficiancy of the human heart (author's transl)]. ( Frisch, P; Klepzig, H; Wolter, H, 1977)
"To address this issue, the authors studied the cardiovascular effects of doxepin in 32 depressed patients with preexisting left ventricular impairment, ventricular arrhythmias, and/or conduction disease."3.68Is doxepin a safer tricyclic for the heart? ( Dalack, GW; Giardina, EG; Glassman, AH; Roose, SP; Walsh, BT; Woodring, S, 1991)
"The effect of doxepin on ventricular arrhythmias, the ECG, and left ventricular function was evaluated in 10 cardiac patients with symptoms with frequent ventricular premature depolarizations in a dose-ranging protocol."3.67Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias. ( Cooper, TB; Giardina, EG; Saroff, AL; Suckow, R, 1987)
"A case is described of ventricular arrhythmias associated with doxepin and amitriptyline treatment in a patient with preexisting heart disease."3.66Ventricular arrhythmias induced by doxepin and amitriptyline: case report. ( Faber, R; Todd, RD, 1983)
"Treatment with imipramine and doxepin, but not placebo, was associated with significant improvement (P less than 0."2.65Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. ( Barnes, RF; Caldwell, JH; Gumbrecht, G; Raskind, MA; Ritchie, JL; Veith, RC, 1982)
" Dx infused intravenously to conscious or anaesthetized guinea-pigs proved as cardiotoxic as amitriptyline but more toxic than protriptyline, thus confirming our previous results in rabbits."1.26Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs. ( Elonen, E; Eränkö, P; Mattila, MJ; Puisto, EL, 1980)
"Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin."1.26Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin. ( Brown, TC; Leversha, A, 1979)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199016 (88.89)18.7374
1990's2 (11.11)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Luchins, DJ1
Todd, RD1
Faber, R1
Puisto, EL2
Mattila, MJ2
Elonen, E1
Eränkö, P1
Veith, RC1
Raskind, MA1
Caldwell, JH1
Barnes, RF1
Gumbrecht, G1
Ritchie, JL1
Marshall, JB1
Forker, AD1
Rechlin, T1
Wolter, H1
Klepzig, H1
Frisch, P1
Brown, TC1
Leversha, A1
Weinberger, DR1
Sivertsen, B1
Roose, SP1
Dalack, GW1
Glassman, AH1
Woodring, S1
Walsh, BT1
Giardina, EG2
Meador-Woodruff, JH1
Majchrzak, MJ1
Anyos, K1
Cooper, TB1
Suckow, R1
Saroff, AL1
Mahapatra, RK1
Paul, SK1
Mahapatra, D1
Winter, S1
Fisch, C1
Barth, N2
Muscholl, E1

Reviews

2 reviews available for doxepin and Arrhythmia

ArticleYear
Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.
    The American journal of psychiatry, 1983, Volume: 140, Issue:8

    Topics: Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Syst

1983
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
    American heart journal, 1982, Volume: 103, Issue:3

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular S

1982

Trials

2 trials available for doxepin and Arrhythmia

ArticleYear
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease.
    The New England journal of medicine, 1982, Apr-22, Volume: 306, Issue:16

    Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease

1982
[The influence of doxepin on the efficiancy of the human heart (author's transl)].
    Medizinische Klinik, 1977, Sep-02, Volume: 72, Issue:35

    Topics: Age Factors; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Doxepin

1977

Other Studies

14 other studies available for doxepin and Arrhythmia

ArticleYear
Ventricular arrhythmias induced by doxepin and amitriptyline: case report.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:11

    Topics: Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Doxepin; Humans; Male; Middle Aged

1983
Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs.
    Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:3

    Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Barium; Doxep

1980
Decreased R-R variation: a criterium for overdosage of tricyclic psychotropic drugs.
    Intensive care medicine, 1995, Volume: 21, Issue:7

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Car

1995
Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
    Clinical toxicology, 1979, Volume: 14, Issue:3

    Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiovascular System; Dogs; Doxepin; Hypotension; Imi

1979
Tricyclic choice for ill elderly patients.
    The American journal of psychiatry, 1977, Volume: 134, Issue:9

    Topics: Aged; Amitriptyline; Arrhythmias, Cardiac; Doxepin; Drug Interactions; Humans; Male; Quinidine

1977
[ECG changes during treatment with Doxepin (Sinquan)].
    Ugeskrift for laeger, 1975, Jun-16, Volume: 137, Issue:25

    Topics: Adult; Aged; Arrhythmias, Cardiac; Doxepin; Electrocardiography; Female; Humans; Male; Middle Aged

1975
Is doxepin a safer tricyclic for the heart?
    The Journal of clinical psychiatry, 1991, Volume: 52, Issue:8

    Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Depressive Disorder; Dose-Response Relationship, Drug; D

1991
Doxepin-induced cardiac dysrhythmia.
    Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:2

    Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; Doxepin; Female; Hea

1988
Cardiotoxic actions of doxepin and barium chloride in conscious rabbits.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1986, Volume: 9

    Topics: Animals; Arrhythmias, Cardiac; Barium; Barium Compounds; Chlorides; Doxepin; Female; Heart; Heart Ra

1986
Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias.
    Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:1

    Topics: Adult; Aged; Arrhythmias, Cardiac; Doxepin; Drug Evaluation; Electrocardiography; Female; Heart Dise

1987
Cardiovascular effects of polycyclic antidepressants.
    Angiology, 1986, Volume: 37, Issue:10

    Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depression;

1986
Effect of fluoxetine on the electrocardiogram.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:3 Pt 2

    Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch

1985
Proceedings: Arrhythmias evoked by infusion of tricyclic antidepressants and noradrenaline on isolated rabbit hearts.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl

    Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Dose-Response Relationship, Drug;

1974
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 284, Issue:3

    Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Autonomic Fibers, Postganglionic; Co

1974