doxepin has been researched along with Arrhythmia in 18 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of doxepin on ventricular arrhythmias, the ECG, and left ventricular function was evaluated in 10 cardiac patients with symptoms with frequent ventricular premature depolarizations in a dose-ranging protocol." | 7.67 | Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias. ( Cooper, TB; Giardina, EG; Saroff, AL; Suckow, R, 1987) |
| "A case is described of ventricular arrhythmias associated with doxepin and amitriptyline treatment in a patient with preexisting heart disease." | 7.66 | Ventricular arrhythmias induced by doxepin and amitriptyline: case report. ( Faber, R; Todd, RD, 1983) |
| "This work was aimed at clarifying whether the anti-depressant doxepin had a cardiodepressant action, or favoured or initiated arrhythmias and/or ventricular conduction disorders, when administered orally for 14 days at a daily dosage of 75 mg." | 5.04 | [The influence of doxepin on the efficiancy of the human heart (author's transl)]. ( Frisch, P; Klepzig, H; Wolter, H, 1977) |
| "To address this issue, the authors studied the cardiovascular effects of doxepin in 32 depressed patients with preexisting left ventricular impairment, ventricular arrhythmias, and/or conduction disease." | 3.68 | Is doxepin a safer tricyclic for the heart? ( Dalack, GW; Giardina, EG; Glassman, AH; Roose, SP; Walsh, BT; Woodring, S, 1991) |
| "The effect of doxepin on ventricular arrhythmias, the ECG, and left ventricular function was evaluated in 10 cardiac patients with symptoms with frequent ventricular premature depolarizations in a dose-ranging protocol." | 3.67 | Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias. ( Cooper, TB; Giardina, EG; Saroff, AL; Suckow, R, 1987) |
| "A case is described of ventricular arrhythmias associated with doxepin and amitriptyline treatment in a patient with preexisting heart disease." | 3.66 | Ventricular arrhythmias induced by doxepin and amitriptyline: case report. ( Faber, R; Todd, RD, 1983) |
| "Treatment with imipramine and doxepin, but not placebo, was associated with significant improvement (P less than 0." | 2.65 | Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease. ( Barnes, RF; Caldwell, JH; Gumbrecht, G; Raskind, MA; Ritchie, JL; Veith, RC, 1982) |
| " Dx infused intravenously to conscious or anaesthetized guinea-pigs proved as cardiotoxic as amitriptyline but more toxic than protriptyline, thus confirming our previous results in rabbits." | 1.26 | Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs. ( Elonen, E; Eränkö, P; Mattila, MJ; Puisto, EL, 1980) |
| "Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin." | 1.26 | Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin. ( Brown, TC; Leversha, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (88.89) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luchins, DJ | 1 |
| Todd, RD | 1 |
| Faber, R | 1 |
| Puisto, EL | 2 |
| Mattila, MJ | 2 |
| Elonen, E | 1 |
| Eränkö, P | 1 |
| Veith, RC | 1 |
| Raskind, MA | 1 |
| Caldwell, JH | 1 |
| Barnes, RF | 1 |
| Gumbrecht, G | 1 |
| Ritchie, JL | 1 |
| Marshall, JB | 1 |
| Forker, AD | 1 |
| Rechlin, T | 1 |
| Wolter, H | 1 |
| Klepzig, H | 1 |
| Frisch, P | 1 |
| Brown, TC | 1 |
| Leversha, A | 1 |
| Weinberger, DR | 1 |
| Sivertsen, B | 1 |
| Roose, SP | 1 |
| Dalack, GW | 1 |
| Glassman, AH | 1 |
| Woodring, S | 1 |
| Walsh, BT | 1 |
| Giardina, EG | 2 |
| Meador-Woodruff, JH | 1 |
| Majchrzak, MJ | 1 |
| Anyos, K | 1 |
| Cooper, TB | 1 |
| Suckow, R | 1 |
| Saroff, AL | 1 |
| Mahapatra, RK | 1 |
| Paul, SK | 1 |
| Mahapatra, D | 1 |
| Winter, S | 1 |
| Fisch, C | 1 |
| Barth, N | 2 |
| Muscholl, E | 1 |
2 reviews available for doxepin and Arrhythmia
| Article | Year |
|---|---|
Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Syst | 1983 |
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular S | 1982 |
2 trials available for doxepin and Arrhythmia
| Article | Year |
|---|---|
Cardiovascular effects of tricyclic antidepressants in depressed patients with chronic heart disease.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease | 1982 |
[The influence of doxepin on the efficiancy of the human heart (author's transl)].
Topics: Age Factors; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Doxepin | 1977 |
14 other studies available for doxepin and Arrhythmia
| Article | Year |
|---|---|
Ventricular arrhythmias induced by doxepin and amitriptyline: case report.
Topics: Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Doxepin; Humans; Male; Middle Aged | 1983 |
Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Barium; Doxep | 1980 |
Decreased R-R variation: a criterium for overdosage of tricyclic psychotropic drugs.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Car | 1995 |
Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiovascular System; Dogs; Doxepin; Hypotension; Imi | 1979 |
Tricyclic choice for ill elderly patients.
Topics: Aged; Amitriptyline; Arrhythmias, Cardiac; Doxepin; Drug Interactions; Humans; Male; Quinidine | 1977 |
[ECG changes during treatment with Doxepin (Sinquan)].
Topics: Adult; Aged; Arrhythmias, Cardiac; Doxepin; Electrocardiography; Female; Humans; Male; Middle Aged | 1975 |
Is doxepin a safer tricyclic for the heart?
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Depressive Disorder; Dose-Response Relationship, Drug; D | 1991 |
Doxepin-induced cardiac dysrhythmia.
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; Doxepin; Female; Hea | 1988 |
Cardiotoxic actions of doxepin and barium chloride in conscious rabbits.
Topics: Animals; Arrhythmias, Cardiac; Barium; Barium Compounds; Chlorides; Doxepin; Female; Heart; Heart Ra | 1986 |
Cardiovascular effects of doxepin in cardiac patients with ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Doxepin; Drug Evaluation; Electrocardiography; Female; Heart Dise | 1987 |
Cardiovascular effects of polycyclic antidepressants.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depression; | 1986 |
Effect of fluoxetine on the electrocardiogram.
Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch | 1985 |
Proceedings: Arrhythmias evoked by infusion of tricyclic antidepressants and noradrenaline on isolated rabbit hearts.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Dose-Response Relationship, Drug; | 1974 |
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Autonomic Fibers, Postganglionic; Co | 1974 |