doxepin has been researched along with Alzheimer Disease in 2 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hajjo, R | 1 |
| Setola, V | 1 |
| Roth, BL | 1 |
| Tropsha, A | 1 |
| Higuchi, M | 1 |
| Yanai, K | 1 |
| Okamura, N | 1 |
| Meguro, K | 1 |
| Arai, H | 1 |
| Itoh, M | 1 |
| Iwata, R | 1 |
| Ido, T | 1 |
| Watanabe, T | 1 |
| Sasaki, H | 1 |
2 other studies available for doxepin and Alzheimer Disease
| Article | Year |
|---|---|
Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.
Topics: Alzheimer Disease; Cell Line, Tumor; Cloning, Molecular; Cognition; Drug Discovery; Drug Evaluation, | 2012 |
Histamine H(1) receptors in patients with Alzheimer's disease assessed by positron emission tomography.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain Chemistry; Carbon Radioisotopes; Cer | 2000 |