Page last updated: 2024-10-26

doxazosin and Mydriasis

doxazosin has been researched along with Mydriasis in 1 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Mydriasis: Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.

Research Excerpts

ExcerptRelevanceReference
" Clonidine did not significantly reduce the mydriatic effects of MDMA, although it produced miosis when administered alone."4.88Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex. ( Hysek, CM; Liechti, ME, 2012)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hysek, CM1
Liechti, ME1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacological Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy): Pharmacodynamics (PD) and Pharmacokinetics (PK)[NCT00990067]Phase 116 participants (Actual)Interventional2009-11-30Completed
Pharmacological Interaction Between Reboxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy): Pharmacological Effects and Pharmacokinetics[NCT00886886]Phase 116 participants (Actual)Interventional2009-04-30Completed
Pharmacological Interaction Between Clonidine and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)[NCT01136278]Phase 116 participants (Actual)Interventional2010-07-31Completed
Interactive Effects of Doxazosin and 3,4-Methylenedioxymethamphetamine (MDMA) in Healthy Subjects[NCT01386177]Phase 116 participants (Actual)Interventional2011-07-31Completed
"Effects of Carvedilol on the Cardiovascular and Subjective Response to MDMA (3,4-Methylenedioxymethamphetamine, Ecstasy)"[NCT01270672]16 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for doxazosin and Mydriasis

ArticleYear
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012
Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
    Psychopharmacology, 2012, Volume: 224, Issue:3

    Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Adult; Affe

2012