doxazosin has been researched along with Muscle Relaxation in 6 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract." | 1.34 | Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment. ( Ali Onur, M; Eroglu, M; Kandirali, E; Metin, A; Semercioz, A; Sezgin, A, 2007) |
| "Tamsulosin was shown to have greater potency than prazosin (more than 100-fold), doxazosin (more than 1000-fold), and terazosin (more than 1000-fold), in relaxation of cavernous smooth muscle." | 1.30 | Comparison of relaxation responses of cavernous and trigonal smooth muscles from rabbits by alpha1-adrenoceptor antagonists; prazosin, terazosin, doxazosin, and tamsulosin. ( Kim, SC; Lee, MY; Lim, SW; Seo, KK, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oger, S | 1 |
| Behr-Roussel, D | 1 |
| Gorny, D | 1 |
| Lecoz, O | 1 |
| Lebret, T | 1 |
| Denoux, Y | 1 |
| Faix, A | 1 |
| Leriche, A | 1 |
| Wayman, C | 1 |
| Alexandre, L | 1 |
| Giuliano, F | 1 |
| Wang, M | 1 |
| Ren, XJ | 1 |
| Zhao, QH | 1 |
| Lin, LX | 1 |
| Wang, X | 1 |
| Zhao, Y | 1 |
| Ren, LM | 1 |
| Eroglu, M | 1 |
| Sezgin, A | 1 |
| Semercioz, A | 1 |
| Metin, A | 1 |
| Kandirali, E | 1 |
| Ali Onur, M | 1 |
| Nakada, SY | 1 |
| Coyle, TL | 1 |
| Ankem, MK | 1 |
| Moon, TD | 1 |
| Jerde, TJ | 1 |
| Yeates, RA | 1 |
| Seo, KK | 1 |
| Lee, MY | 1 |
| Lim, SW | 1 |
| Kim, SC | 1 |
1 trial available for doxazosin and Muscle Relaxation
| Article | Year |
|---|---|
Combination of doxazosin and sildenafil exerts an additive relaxing effect compared with each compound alone on human cavernosal and prostatic tissue.
Topics: Adrenergic alpha-Antagonists; Adult; Doxazosin; Drug Combinations; Erectile Dysfunction; Humans; Mal | 2009 |
5 other studies available for doxazosin and Muscle Relaxation
| Article | Year |
|---|---|
Relaxant and contractile responses of detrusor muscle strips obtained from bladder outlet-obstructed rats treated with doxazosin enantiomers.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Agonists; Animals; Carbachol; Cholinergic A | 2011 |
Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Doxazosin; Epinephrine; Male; Muscle Contr | 2007 |
Doxazosin relaxes ureteral smooth muscle and inhibits epinephrine-induced ureteral contractility in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; | 2007 |
Influence of doxazosin on the activity of the endothelium-derived relaxing factor.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcimycin; Doxazosin; In Vitro Tec | 1994 |
Comparison of relaxation responses of cavernous and trigonal smooth muscles from rabbits by alpha1-adrenoceptor antagonists; prazosin, terazosin, doxazosin, and tamsulosin.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Doxazosin; In Vitro | 1999 |