doxazosin has been researched along with Muscle Contraction in 29 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present in vitro study investigated the influence of doxazosin on the contractility of the urinary bladder in female pigs with experimentally induced cystitis." | 9.24 | The influence of doxazosin on the contractility of the urinary bladder in female pigs with experimentally induced cystitis. ( Bossowska, A; Jaroszewski, JJ; Lepiarczyk, E; Majewski, M; Markiewicz, W; Radziszewski, P; Wiśniewska, A, 2017) |
| "3H-Doxazosin binding sites were characterized in canine brain and human prostate homogenates using saturation experiments." | 5.28 | Binding and functional properties of doxazosin in the human prostate adenoma and canine brain. ( Baumann, M; Lepor, H; Shapiro, E, 1990) |
| "The present in vitro study investigated the influence of doxazosin on the contractility of the urinary bladder in female pigs with experimentally induced cystitis." | 5.24 | The influence of doxazosin on the contractility of the urinary bladder in female pigs with experimentally induced cystitis. ( Bossowska, A; Jaroszewski, JJ; Lepiarczyk, E; Majewski, M; Markiewicz, W; Radziszewski, P; Wiśniewska, A, 2017) |
| " A U-shaped dose-response curve to compounds with mixed alpha 2- and alpha 1-antagonist properties may be constructed, which emphasizes the importance of the dose-dependent selectivity of these antagonists at alpha 2- and alpha 1-receptors." | 2.66 | Human vascular smooth muscle responses mediated by alpha 2 mechanisms in vivo and in vitro. ( Calvete, J; Hayes, R; Martin, G; Sever, P; Thom, S, 1985) |
| " The results of our study have shown that long-term administration of doxazosin caused a desensitization of the detrusor smooth muscle for in vitro applied mediators of the autonomic nervous systems." | 1.40 | The influence of doxazosin, an alpha1-adrenergic receptor antagonist on the urinary bladder contractility in pigs. ( Barski, D; Bossowska, A; Janiuk, J; Jaroszewski, JJ; Jasiecka, A; Markiewicz, W, 2014) |
| "Doxazosin treatment significantly increased membrane-bound IRAP specific activity in rat prostate by 59." | 1.37 | Alpha-1-adrenergic receptor blockade modifies insulin-regulated aminopeptidase (IRAP) activity in rat prostate and modulates oxytocin functions. ( Carrera-González, MP; de la Chica, S; Manuel Martínez-Martos, J; Mayas, MD; Ramírez-Expósito, MJ; Saníger, MA, 2011) |
| "It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract." | 1.34 | Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment. ( Ali Onur, M; Eroglu, M; Kandirali, E; Metin, A; Semercioz, A; Sezgin, A, 2007) |
| "Tamsulosin was also administered to male rats (group IV)." | 1.33 | The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat. ( Bae, JH; Jung, PB; Lee, JG, 2005) |
| "Doxazosin and Y-27632 generate effective CCSM relaxation in the presence of BOO." | 1.33 | Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction. ( Aslan, G; Demir, O; Esen, AA; Gidener, S; Murat, N, 2006) |
| "Doxazosin was more effective in decreasing contractions when it was combined with sildenafil or the nitric oxide (NO) precursor L-arginine." | 1.32 | Chronic ischemia increases prostatic smooth muscle contraction in the rabbit. ( Azadzoi, KM; Babayan, RK; Kozlowski, R; Siroky, MB, 2003) |
| "Doxazosin (dox) is a clinically effective alpha-adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia (BPH)." | 1.31 | Effect of doxazosin on rat urinary bladder function after partial outlet obstruction. ( Das, AK; Eagen, G; Leggett, RE; Levin, RM; Whitbeck, C, 2002) |
| "Tamsulosin was shown to have greater potency than prazosin (more than 100-fold), doxazosin (more than 1000-fold), and terazosin (more than 1000-fold), in relaxation of cavernous smooth muscle." | 1.30 | Comparison of relaxation responses of cavernous and trigonal smooth muscles from rabbits by alpha1-adrenoceptor antagonists; prazosin, terazosin, doxazosin, and tamsulosin. ( Kim, SC; Lee, MY; Lim, SW; Seo, KK, 1999) |
| "(-)-Tamsulosin was a very potent, insurmountable antagonist of noradrenaline-mediated contractions of human prostate, yielding an approximate pA2 estimate of 9." | 1.29 | Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies. ( Chalmers, DH; Kenny, BA; Miller, AM; Naylor, AM; O'Connell, J; Williamson, IJ, 1996) |
| "3H-Doxazosin binding sites were characterized in canine brain and human prostate homogenates using saturation experiments." | 1.28 | Binding and functional properties of doxazosin in the human prostate adenoma and canine brain. ( Baumann, M; Lepor, H; Shapiro, E, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.34) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Britto-Júnior, J | 1 |
| da Silva-Filho, WP | 1 |
| Amorim, AC | 1 |
| Campos, R | 1 |
| Moraes, MO | 1 |
| Moraes, MEA | 1 |
| Fregonesi, A | 1 |
| Monica, FZ | 1 |
| Antunes, E | 1 |
| De Nucci, G | 1 |
| Markiewicz, W | 2 |
| Bossowska, A | 2 |
| Lepiarczyk, E | 1 |
| Majewski, M | 1 |
| Radziszewski, P | 1 |
| Wiśniewska, A | 1 |
| Jaroszewski, JJ | 2 |
| Zhao, Y | 2 |
| Cao, XB | 1 |
| Ren, LM | 2 |
| Jasiecka, A | 1 |
| Barski, D | 1 |
| Janiuk, J | 1 |
| Gumrah, A | 1 |
| Tanidir, Y | 1 |
| Tinay, I | 1 |
| Ozyurek, M | 1 |
| Tarcan, T | 1 |
| Kobayashi, S | 1 |
| Tomiyama, Y | 1 |
| Maruyama, K | 1 |
| Hoyano, Y | 1 |
| Yamazaki, Y | 1 |
| Kusama, H | 1 |
| Saníger, MA | 1 |
| Ramírez-Expósito, MJ | 1 |
| de la Chica, S | 1 |
| Carrera-González, MP | 1 |
| Mayas, MD | 1 |
| Manuel Martínez-Martos, J | 1 |
| Wang, M | 1 |
| Ren, XJ | 1 |
| Zhao, QH | 1 |
| Lin, LX | 1 |
| Wang, X | 1 |
| Azadzoi, KM | 1 |
| Babayan, RK | 1 |
| Kozlowski, R | 1 |
| Siroky, MB | 1 |
| Bae, JH | 1 |
| Jung, PB | 1 |
| Lee, JG | 1 |
| Demir, O | 1 |
| Murat, N | 1 |
| Aslan, G | 1 |
| Gidener, S | 1 |
| Esen, AA | 1 |
| Kilicarslan, H | 1 |
| Ayan, S | 1 |
| Vuruskan, H | 1 |
| Gokce, G | 1 |
| Gultekin, EY | 1 |
| Eroglu, M | 1 |
| Sezgin, A | 1 |
| Semercioz, A | 1 |
| Metin, A | 1 |
| Kandirali, E | 1 |
| Ali Onur, M | 1 |
| Colabufo, NA | 1 |
| Pagliarulo, V | 1 |
| Berardi, F | 1 |
| Contino, M | 1 |
| Perrone, R | 1 |
| Niso, M | 1 |
| Albo, G | 1 |
| de Rienzo, G | 1 |
| Pagliarulo, A | 1 |
| Nakada, SY | 1 |
| Coyle, TL | 1 |
| Ankem, MK | 1 |
| Moon, TD | 1 |
| Jerde, TJ | 1 |
| van Mastrigt, R | 1 |
| Kenny, BA | 1 |
| Miller, AM | 1 |
| Williamson, IJ | 1 |
| O'Connell, J | 1 |
| Chalmers, DH | 1 |
| Naylor, AM | 1 |
| Simonsen, U | 1 |
| Prieto, D | 1 |
| Nyborg, NC | 1 |
| Mulvany, MJ | 1 |
| Giardinà, D | 1 |
| Crucianelli, M | 1 |
| Marucci, G | 1 |
| Melchiorre, C | 1 |
| Polidori, C | 1 |
| Pompei, P | 1 |
| Massi, M | 1 |
| Esteban Fuertes, M | 1 |
| Salinas Casado, J | 1 |
| Virseda Chamorro, M | 1 |
| Ramírez Fernández, JC | 1 |
| Salomon Moh'd, S | 1 |
| Luengo Alpuente, S | 1 |
| Resel Estévez, L | 1 |
| Seo, KK | 1 |
| Lee, MY | 1 |
| Lim, SW | 1 |
| Kim, SC | 1 |
| Kaplan, SA | 1 |
| Stifelman, M | 1 |
| Avillo, C | 1 |
| Reis, RB | 1 |
| Te, AE | 1 |
| Khan, MA | 1 |
| Thompson, CS | 1 |
| Dashwood, MR | 1 |
| Mumtaz, FH | 1 |
| Mikhailidis, DP | 1 |
| Morgan, RJ | 1 |
| Boesch, ST | 1 |
| Dobler, G | 1 |
| Ramoner, R | 1 |
| Corvin, S | 1 |
| Thurnher, M | 1 |
| Bartsch, G | 1 |
| Klocker, H | 1 |
| Das, AK | 1 |
| Leggett, RE | 1 |
| Whitbeck, C | 1 |
| Eagen, G | 1 |
| Levin, RM | 1 |
| Lepor, H | 1 |
| Baumann, M | 1 |
| Shapiro, E | 1 |
| Thom, S | 2 |
| Hayes, R | 2 |
| Calvete, J | 2 |
| Sever, PS | 1 |
| Martin, G | 1 |
| Sever, P | 1 |
| Alabaster, VA | 1 |
| Davey, MJ | 1 |
2 trials available for doxazosin and Muscle Contraction
| Article | Year |
|---|---|
The influence of doxazosin on the contractility of the urinary bladder in female pigs with experimentally induced cystitis.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Animals; Cholinergic Agonists; Cystitis; Dox | 2017 |
Human vascular smooth muscle responses mediated by alpha 2 mechanisms in vivo and in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Arteries; Brimonidine Tartrate; Diox | 1985 |
27 other studies available for doxazosin and Muscle Contraction
| Article | Year |
|---|---|
6-nitrodopamine is a major endogenous modulator of human vas deferens contractility.
Topics: Adrenergic Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Carbamazepine; Chr | 2022 |
Doxazosin selectively potentiates contraction to serotonin via 5-HT₂A receptors in longitudinal muscle strips of the rabbit gastric body.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Doxazosin; In Vitro Techniques; Muscle Contraction | 2014 |
The influence of doxazosin, an alpha1-adrenergic receptor antagonist on the urinary bladder contractility in pigs.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Doxazosin; Muscle Contraction; Muscle, Smooth; Swi | 2014 |
The effect of doxazosin and sildenafil citrate combination on bladder tissue contractility, alpha adrenergic receptor, and iNOS subtype expression in a male rat model of partially bladder outlet obstruction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Carbachol; Disease Models, Animal; Doxazosin; Male | 2017 |
Effects of four different alpha(1)-adrenoceptor antagonists on alpha-adrenoceptor agonist-induced contractions in isolated mouse and hamster ureters.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 2009 |
Alpha-1-adrenergic receptor blockade modifies insulin-regulated aminopeptidase (IRAP) activity in rat prostate and modulates oxytocin functions.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cystinyl Aminopeptidase; Doxazosin; Immunoenzyme T | 2011 |
Relaxant and contractile responses of detrusor muscle strips obtained from bladder outlet-obstructed rats treated with doxazosin enantiomers.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Agonists; Animals; Carbachol; Cholinergic A | 2011 |
Chronic ischemia increases prostatic smooth muscle contraction in the rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Arginine; Arteriosclerosis; Blood Flow Velocity; Cyclic GMP; | 2003 |
The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Doxazosin; Female; Male; Muscle Contraction; | 2005 |
Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction.
Topics: Adrenergic alpha-Antagonists; Aged; Amides; Dose-Response Relationship, Drug; Doxazosin; Erectile Dy | 2006 |
Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Baclofen; Doxazosin; Female; Humans; Middle A | 2006 |
Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Doxazosin; Epinephrine; Male; Muscle Contr | 2007 |
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aged; Dose-Response Relationship, D | 2007 |
Doxazosin relaxes ureteral smooth muscle and inhibits epinephrine-induced ureteral contractility in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; | 2007 |
Quantification of lower urinary tract function and dysfunction.
Topics: Doxazosin; Female; Humans; Male; Muscle Contraction; Pilot Projects; Postoperative Period; Prostate; | 1993 |
Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Blood Pressure; D | 1996 |
Effects of doxazosin on functional alterations of isolated coronary arteries from cholesterol-fed rabbits.
Topics: Adrenergic alpha-Antagonists; Animals; Cholesterol; Cholesterol, Dietary; Coronary Circulation; Coro | 1996 |
Pharmacological evaluation of prazosin- and doxazosin-related compounds with modified piperazine ring.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Doxazosin; In Vitro Techniques; Injections, I | 1996 |
[Doxazosin treatment of disorders of the voiding phase in benign prostatic hyperplasia].
Topics: Adrenergic alpha-Antagonists; Aged; Doxazosin; Humans; Male; Middle Aged; Muscle Contraction; Prospe | 1997 |
Comparison of relaxation responses of cavernous and trigonal smooth muscles from rabbits by alpha1-adrenoceptor antagonists; prazosin, terazosin, doxazosin, and tamsulosin.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Doxazosin; In Vitro | 1999 |
Detrusor contraction duration may predict response to alpha-blocker therapy for lower urinary tract symptoms.
Topics: Adrenergic alpha-Antagonists; Doxazosin; Humans; Male; Middle Aged; Muscle Contraction; Predictive V | 2000 |
Doxazosin modifies serotonin-mediated rabbit urinary bladder contraction. Potential clinical relevance.
Topics: Animals; Autoradiography; Doxazosin; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; | 2000 |
Effects of alpha1-adrenoceptor antagonists on cultured prostatic smooth muscle cells.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Ap | 2000 |
Effect of doxazosin on rat urinary bladder function after partial outlet obstruction.
Topics: Adenosine Triphosphate; Administration, Oral; Adrenergic alpha-Antagonists; Animals; Blood Flow Velo | 2002 |
Binding and functional properties of doxazosin in the human prostate adenoma and canine brain.
Topics: Adenoma; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Dogs; Doxazosin; Humans | 1990 |
In vivo and in vitro studies of alpha 2-adrenoceptor responses in human vascular smooth muscle.
Topics: Adult; Animals; Arm; Brimonidine Tartrate; Dioxanes; Dioxins; Doxazosin; Epinephrine; Humans; Idazox | 1985 |
The alpha 1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Angiotensin II; Animals; Antihypertensive Agents; Cats; Do | 1986 |