Page last updated: 2024-10-26

doxazosin and Liver Cirrhosis

doxazosin has been researched along with Liver Cirrhosis in 6 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Research Excerpts

ExcerptRelevanceReference
" The present study analyzed the effect of bone morphogenetic protein (BMP)‑7 gene therapy with or without co‑treatment with doxazosin in a model of liver cirrhosis in hamsters."3.85Adenoviral‑bone morphogenetic protein‑7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model. ( Aldaba-Muruato, LR; Borrego-Soto, G; Cervantes-Garcia, D; Cuellar-Juarez, AG; Muñoz-Ortega, MH; Rojas-Martinez, A; Salinas, E; Ventura-Juarez, J, 2017)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Serna-Salas, SA1
Arroyave-Ospina, JC1
Zhang, M1
Damba, T1
Buist-Homan, M1
Muñoz-Ortega, MH3
Ventura-Juárez, J3
Moshage, H1
Xiu, AY1
Ding, Q1
Li, Z1
Zhang, CQ1
Cervantes-Garcia, D2
Cuellar-Juarez, AG1
Borrego-Soto, G1
Rojas-Martinez, A1
Aldaba-Muruato, LR1
Salinas, E1
Llamas-Ramírez, RW1
Romero-Delgadillo, NI1
Elías-Flores, TG1
Tavares-Rodríguez, Ede J1
Campos-Esparza, Mdel R1
Muñoz-Fernández, L1
Gerardo-Rodríguez, M1
Paik, YH1
Kalambokis, GN1
Pappas, K1
Tsianos, EV1

Other Studies

6 other studies available for doxazosin and Liver Cirrhosis

ArticleYear
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate cells activation via induction of senescence.
    Mechanisms of ageing and development, 2022, Volume: 201

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Cell Cycle Checkpoints;

2022
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Autophagy; Carbon Tetrachloride; Cell L

2021
Adenoviral‑bone morphogenetic protein‑7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model.
    Molecular medicine reports, 2017, Volume: 16, Issue:6

    Topics: Adenoviridae; Adrenergic alpha-Antagonists; Animals; Bone Morphogenetic Protein 7; Collagen Type I;

2017
Doxazosin Treatment Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor β Secretion.
    Gut and liver, 2016, Volume: 10, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferases;

2016
Reappraisal of Antihypertensive Medicine Doxazosin and Carvedilol as a Potential Therapeutic for Hepatic Fibrosis.
    Gut and liver, 2016, Volume: 10, Issue:1

    Topics: Antihypertensive Agents; Doxazosin; Humans; Liver Cirrhosis

2016
Effect of alpha1-blockade with doxazosin in pulmonary hypertension associated with cirrhosis.
    Scandinavian journal of gastroenterology, 2010, Volume: 45, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Doxazosin; Female; Humans; Hypertension, Pulmonary; L

2010