doxazosin has been researched along with Invasiveness, Neoplasm in 5 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two cell lines were used: renal cell carcinoma (RCC) 786-0, harboring a von Hippel-Lindau (VHL) tumor-suppressor gene mutation with a highly angiogenic phenotype, and Caki cells (no VHL mutation)." | 1.37 | Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma. ( Kyprianou, N; Sakamoto, S; Schwarze, S, 2011) |
| "Androgen independent PC-3 prostate cancer cells and PC-3 transfectant clones over expressing the apoptosis suppressor bcl-2 were used as an in vitro model." | 1.32 | Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2. ( Keledjian, K; Kyprianou, N, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ricci, B | 1 |
| Millner, TO | 1 |
| Pomella, N | 1 |
| Zhang, X | 1 |
| Guglielmi, L | 1 |
| Badodi, S | 1 |
| Ceric, D | 1 |
| Gemma, C | 1 |
| Cognolato, E | 1 |
| Zhang, Y | 1 |
| Brandner, S | 1 |
| Barnes, MR | 1 |
| Marino, S | 1 |
| de Marcondes, PG | 1 |
| Bastos, LG | 1 |
| de-Freitas-Junior, JC | 1 |
| Rocha, MR | 1 |
| Morgado-Díaz, JA | 1 |
| Sakamoto, S | 1 |
| Schwarze, S | 1 |
| Kyprianou, N | 2 |
| Johansson, M | 1 |
| Keledjian, K | 1 |
5 other studies available for doxazosin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma.
Topics: Animals; Antihypertensive Agents; Cell Proliferation; Doxazosin; Drug Delivery Systems; Ephrin-A5; E | 2020 |
EphA4-mediated signaling regulates the aggressive phenotype of irradiation survivor colorectal cancer cells.
Topics: Antigens, CD; Cadherins; Colorectal Neoplasms; Doxazosin; Extracellular Signal-Regulated MAP Kinases | 2016 |
Anoikis disruption of focal adhesion-Akt signaling impairs renal cell carcinoma.
Topics: Adrenergic alpha-1 Receptor Antagonists; Anoikis; Antineoplastic Agents; Carcinoma, Renal Cell; Casp | 2011 |
Lord of the rings: a promising novel treatment for renal cell carcinoma?
Topics: Adrenergic alpha-1 Receptor Antagonists; Anoikis; Antineoplastic Agents; Carcinoma, Renal Cell; Cell | 2011 |
Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anoikis; Cell Adhesion; Cell | 2003 |