Page last updated: 2024-10-26

doxazosin and Hypotension

doxazosin has been researched along with Hypotension in 10 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"The objective of the present study was to examine the effects of administration of an alpha 1-adrenoceptor antagonist, doxazosin, for 7 days on cerebral blood flow and the autoregulatory response to hypotension in anesthetized spontaneously hypertensive rats."7.69The alpha 1-adrenoceptor antagonist, doxazosin, modulates the lower limit of autoregulation of cerebral blood flow during hemorrhagic hypotension in anesthetized hypertensive rats. ( Cai, H; Fujishima, M; Ibayashi, S; Sadoshima, S; Sugimori, H; Yao, H, 1995)
"Treatment of benign prostatic hyperplasia (BPH) with nonselective alpha1 antagonists such as terazosin, doxazosin, and prazosin results in blood pressure reduction due to vasodilation."3.71Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study. ( Chao, J; Chrischilles, E; Gilden, D; Kreder, KJ; Rubenstein, L; Shah, H, 2001)
"The objective of the present study was to examine the effects of administration of an alpha 1-adrenoceptor antagonist, doxazosin, for 7 days on cerebral blood flow and the autoregulatory response to hypotension in anesthetized spontaneously hypertensive rats."3.69The alpha 1-adrenoceptor antagonist, doxazosin, modulates the lower limit of autoregulation of cerebral blood flow during hemorrhagic hypotension in anesthetized hypertensive rats. ( Cai, H; Fujishima, M; Ibayashi, S; Sadoshima, S; Sugimori, H; Yao, H, 1995)
"In conclusion, intraoperative complications in pheochromocytoma surgery are common and can be potentially life-threatening."1.62Risk factors for intraoperative complications in pheochromocytomas. ( Álvarez-Escolá, C; Araujo-Castro, M; Blanco-Carrera, C; Calatayud Gutiérrez, M; de Miguel Novoa, P; Fernández-Ladreda, MT; Garcia Centeno, R; Gómez Dos Santos, V; Gracia Gimeno, P; Hanzu, FA; Lamas, C; López-García, MC; Mínguez Ojeda, C; Mora, M; Percovich Hualpa, JC; Serrano Romero, A; Valdés, N; Vidal, Ó, 2021)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's3 (30.00)18.2507
2000's3 (30.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Araujo-Castro, M1
Garcia Centeno, R1
López-García, MC1
Lamas, C1
Álvarez-Escolá, C1
Calatayud Gutiérrez, M1
Blanco-Carrera, C1
de Miguel Novoa, P1
Valdés, N1
Gracia Gimeno, P1
Fernández-Ladreda, MT1
Mínguez Ojeda, C1
Percovich Hualpa, JC1
Mora, M1
Vidal, Ó1
Serrano Romero, A1
Hanzu, FA1
Gómez Dos Santos, V1
Belayneh, M1
Korownyk, C1
Nakaigawa, N1
Komatsu, R1
Kamata, K1
Ozaki, M1
Kieback, AG1
Rödiger, O1
Jaenecke, H1
Grohmann, A1
Wernecke, KD1
Baumann, G1
Felix, SB1
Hall, GC1
McMahon, AD1
Rubin, PC1
Brunton, J1
Meredith, P1
Kooman, JP1
van Hooff, JP1
Leunissen, KM1
Takishita, S1
Muratani, H1
Kawazoe, N1
Kimura, Y1
Tozawa, M1
Fukiyama, K1
Cai, H1
Ibayashi, S1
Yao, H1
Sugimori, H1
Sadoshima, S1
Fujishima, M1
Chrischilles, E1
Rubenstein, L1
Chao, J1
Kreder, KJ1
Gilden, D1
Shah, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases With Benign Prostatic Hyperplasia[NCT03144596]Phase 463 participants (Actual)Interventional2015-10-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for doxazosin and Hypotension

ArticleYear
Treatment of lower urinary tract symptoms in benign prostatic hypertrophy with α-blockers.
    Canadian family physician Medecin de famille canadien, 2016, Volume: 62, Issue:9

    Topics: Adrenergic alpha-Antagonists; Dizziness; Doxazosin; Humans; Hypotension; Lower Urinary Tract Symptom

2016
The venous system and dialysis-associated hypotension.
    Contributions to nephrology, 1994, Volume: 106

    Topics: Blood Volume; Body Fluid Compartments; Doxazosin; Humans; Hypertension, Renal; Hypotension; Kidney F

1994

Trials

1 trial available for doxazosin and Hypotension

ArticleYear
Hemodynamic effects of alpha1-adrenoceptor antagonist, doxazosin, in patients with chronic congestive heart failure.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:4

    Topics: Adrenergic alpha-Antagonists; Aged; Chronic Disease; Double-Blind Method; Doxazosin; Electrocardiogr

2005

Other Studies

7 other studies available for doxazosin and Hypotension

ArticleYear
Risk factors for intraoperative complications in pheochromocytomas.
    Endocrine-related cancer, 2021, 09-08, Volume: 28, Issue:11

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Doxazosin; Female; Humans; Hydrocortisone; Hypo

2021
[Anesthetic management of a patient with pheochromocytoma and end-stage renal disease].
    Masui. The Japanese journal of anesthesiology, 2010, Volume: 59, Issue:6

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Anesthesia, General; Cervical Vertebrae; Chro

2010
Comparative study of modified release alpha-blocker exposure in elderly patients with fractures.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:8

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Case-Control Studies; Delayed-Action Preparat

2007
Determination of the vasodilator UK33274 by high-performance liquid chromatography using fluorescence detection.
    Journal of chromatography, 1980, Nov-14, Volume: 221, Issue:1

    Topics: Chromatography, High Pressure Liquid; Doxazosin; Humans; Hypotension; Prazosin; Quinazolines; Vasodi

1980
Neural effects on renal blood flow during acute hypotension vary with antihypertensive drugs.
    Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:1 Suppl

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dihydropyridines; Doxazosin; Hypotensio

1994
The alpha 1-adrenoceptor antagonist, doxazosin, modulates the lower limit of autoregulation of cerebral blood flow during hemorrhagic hypotension in anesthetized hypertensive rats.
    European journal of pharmacology, 1995, Nov-24, Volume: 286, Issue:3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Cerebrovascular Circ

1995
Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.
    Clinical therapeutics, 2001, Volume: 23, Issue:5

    Topics: Accidental Falls; Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Cohort Studies; Comor

2001