doxazosin has been researched along with Glioblastoma in 4 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This includes less toxic drugs, more selective towards tumor cells, causing less damage to the patient." | 5.43 | Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity. ( Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V, 2016) |
| " This includes less toxic drugs, more selective towards tumor cells, causing less damage to the patient." | 1.43 | Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity. ( Battastini, AM; Coelho, BP; de Quadros, AH; Gaelzer, MM; Gonçalves, CA; Guerra, MC; Guma, FC; Hoppe, JB; Salbego, CG; Setton-Avruj, P; Terra, SR; Usach, V, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ricci, B | 1 |
| Millner, TO | 1 |
| Pomella, N | 1 |
| Zhang, X | 1 |
| Guglielmi, L | 1 |
| Badodi, S | 1 |
| Ceric, D | 1 |
| Gemma, C | 1 |
| Cognolato, E | 1 |
| Zhang, Y | 1 |
| Brandner, S | 1 |
| Barnes, MR | 1 |
| Marino, S | 1 |
| Orahoske, CM | 1 |
| Li, Y | 1 |
| Petty, A | 1 |
| Salem, FM | 1 |
| Hanna, J | 1 |
| Zhang, W | 1 |
| Su, B | 1 |
| Wang, B | 1 |
| Staudacher, I | 1 |
| Jehle, J | 1 |
| Staudacher, K | 1 |
| Pledl, HW | 1 |
| Lemke, D | 1 |
| Schweizer, PA | 1 |
| Becker, R | 1 |
| Katus, HA | 1 |
| Thomas, D | 1 |
| Gaelzer, MM | 1 |
| Coelho, BP | 1 |
| de Quadros, AH | 1 |
| Hoppe, JB | 1 |
| Terra, SR | 1 |
| Guerra, MC | 1 |
| Usach, V | 1 |
| Guma, FC | 1 |
| Gonçalves, CA | 1 |
| Setton-Avruj, P | 1 |
| Battastini, AM | 1 |
| Salbego, CG | 1 |
4 other studies available for doxazosin and Glioblastoma
| Article | Year |
|---|---|
Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma.
Topics: Animals; Antihypertensive Agents; Cell Proliferation; Doxazosin; Drug Delivery Systems; Ephrin-A5; E | 2020 |
Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Dimerization; Doxazosin; | 2020 |
HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells.
Topics: Apoptosis; Brain Neoplasms; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cytoprotection; Des | 2014 |
Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Caspase 3; Cell Line, Tumor; | 2016 |