doxazosin and Drug-Related Side Effects and Adverse Reactions
doxazosin has been researched along with Drug-Related Side Effects and Adverse Reactions in 5 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The role of doxazosin in treatment of hypertension remains controversial." | 5.13 | Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial. ( Chang, CL; Chapman, N; Dahlöf, B; Poulter, NR; Sever, PS; Wedel, H, 2008) |
"In Langendorff-perfused adult rat heart with constant pressure at 80 mmHg, we found doxazosin, an alpha(1) adrenoceptor blocker, at 10 muM prolonged PR interval and induced occasional arrhythmia followed by complete inhibition of the sinus rhythm, whereas bunazosin, another alpha(1)-blocker, at same concentration did not." | 3.74 | Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin. ( Chen, WP; Lee, AS; Su, MJ, 2008) |
" Frailty may contribute to both symptom progression and serious adverse events (SAEs), shifting the balance of benefits and harms of drug therapy." | 1.62 | Assessment of Frailty and Association With Progression of Benign Prostatic Hyperplasia Symptoms and Serious Adverse Events Among Men Using Drug Therapy. ( Bauer, SR; Covinsky, K; Ensrud, KE; Liu, TT; McVary, KT; Newman, JC; Ricke, WA; Suskind, AM; Walter, LC, 2021) |
"5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
Research
Studies (5)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (60.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Matthews, EJ | 1 |
Kruhlak, NL | 1 |
Weaver, JL | 1 |
Benz, RD | 1 |
Contrera, JF | 1 |
Liu, Z | 1 |
Shi, Q | 1 |
Ding, D | 1 |
Kelly, R | 1 |
Fang, H | 1 |
Tong, W | 1 |
Bauer, SR | 1 |
Walter, LC | 1 |
Ensrud, KE | 1 |
Suskind, AM | 1 |
Newman, JC | 1 |
Ricke, WA | 1 |
Liu, TT | 1 |
McVary, KT | 1 |
Covinsky, K | 1 |
Chapman, N | 1 |
Chang, CL | 1 |
Dahlöf, B | 1 |
Sever, PS | 1 |
Wedel, H | 1 |
Poulter, NR | 1 |
Lee, AS | 1 |
Chen, WP | 1 |
Su, MJ | 1 |
Trials
1 trial available for doxazosin and Drug-Related Side Effects and Adverse Reactions
Article | Year |
---|---|
Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Glucose; Blood Pressure; Dose-Response | 2008 |
Other Studies
4 other studies available for doxazosin and Drug-Related Side Effects and Adverse Reactions
Article | Year |
---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Assessment of Frailty and Association With Progression of Benign Prostatic Hyperplasia Symptoms and Serious Adverse Events Among Men Using Drug Therapy.
Topics: Aged; Aged, 80 and over; Disease Progression; Doxazosin; Drug Therapy, Combination; Drug-Related Sid | 2021 |
Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin.
Topics: Animals; Arrhythmias, Cardiac; Cardiac Electrophysiology; Doxazosin; Drug-Related Side Effects and A | 2008 |