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doxazosin and Drug-Related Side Effects and Adverse Reactions

doxazosin has been researched along with Drug-Related Side Effects and Adverse Reactions in 5 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.

Research Excerpts

ExcerptRelevanceReference
"The role of doxazosin in treatment of hypertension remains controversial."5.13Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial. ( Chang, CL; Chapman, N; Dahlöf, B; Poulter, NR; Sever, PS; Wedel, H, 2008)
"In Langendorff-perfused adult rat heart with constant pressure at 80 mmHg, we found doxazosin, an alpha(1) adrenoceptor blocker, at 10 muM prolonged PR interval and induced occasional arrhythmia followed by complete inhibition of the sinus rhythm, whereas bunazosin, another alpha(1)-blocker, at same concentration did not."3.74Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin. ( Chen, WP; Lee, AS; Su, MJ, 2008)
" Frailty may contribute to both symptom progression and serious adverse events (SAEs), shifting the balance of benefits and harms of drug therapy."1.62Assessment of Frailty and Association With Progression of Benign Prostatic Hyperplasia Symptoms and Serious Adverse Events Among Men Using Drug Therapy. ( Bauer, SR; Covinsky, K; Ensrud, KE; Liu, TT; McVary, KT; Newman, JC; Ricke, WA; Suskind, AM; Walter, LC, 2021)
"5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects."1.32Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Matthews, EJ1
Kruhlak, NL1
Weaver, JL1
Benz, RD1
Contrera, JF1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W1
Bauer, SR1
Walter, LC1
Ensrud, KE1
Suskind, AM1
Newman, JC1
Ricke, WA1
Liu, TT1
McVary, KT1
Covinsky, K1
Chapman, N1
Chang, CL1
Dahlöf, B1
Sever, PS1
Wedel, H1
Poulter, NR1
Lee, AS1
Chen, WP1
Su, MJ1

Trials

1 trial available for doxazosin and Drug-Related Side Effects and Adverse Reactions

ArticleYear
Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial.
    Circulation, 2008, Jul-01, Volume: 118, Issue:1

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Glucose; Blood Pressure; Dose-Response

2008

Other Studies

4 other studies available for doxazosin and Drug-Related Side Effects and Adverse Reactions

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru

2004
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Assessment of Frailty and Association With Progression of Benign Prostatic Hyperplasia Symptoms and Serious Adverse Events Among Men Using Drug Therapy.
    JAMA network open, 2021, 11-01, Volume: 4, Issue:11

    Topics: Aged; Aged, 80 and over; Disease Progression; Doxazosin; Drug Therapy, Combination; Drug-Related Sid

2021
Comparison of the cardiac electrophysiological effects between doxazosin and bunazosin.
    Journal of biomedical science, 2008, Volume: 15, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Cardiac Electrophysiology; Doxazosin; Drug-Related Side Effects and A

2008
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