Page last updated: 2024-10-26

doxazosin and Cardiac Output, Low

doxazosin has been researched along with Cardiac Output, Low in 4 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.

Research Excerpts

ExcerptRelevanceReference
"In high-risk patients with hypertension, the higher risk for heart failure while taking doxazosin compared with chlorthalidone is attenuated but not eliminated by adding other antihypertensive drugs."5.10Relationship of antihypertensive treatment regimens and change in blood pressure to risk for heart failure in hypertensive patients randomly assigned to doxazosin or chlorthalidone: further analyses from the Antihypertensive and Lipid-Lowering treatment t ( Cutler, JA; Davis, BR; Farber, MA; Felicetta, JV; Furberg, CD; Stokes, JD; Wright, JT, 2002)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, BR1
Cutler, JA1
Furberg, CD1
Wright, JT1
Farber, MA1
Felicetta, JV1
Stokes, JD1
Witte, KK1
Thackray, SD1
Nikitin, NP1
Cleland, JG1
Clark, AL1
Verma, SP1
Silke, B1
Reynolds, GW1
Kelly, JG1
Richmond, A1
Taylor, SH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000542]Phase 30 participants Interventional1993-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for doxazosin and Cardiac Output, Low

ArticleYear
Relationship of antihypertensive treatment regimens and change in blood pressure to risk for heart failure in hypertensive patients randomly assigned to doxazosin or chlorthalidone: further analyses from the Antihypertensive and Lipid-Lowering treatment t
    Annals of internal medicine, 2002, Sep-03, Volume: 137, Issue:5 Part 1

    Topics: Antihypertensive Agents; Blood Pressure; Cardiac Output, Low; Chlorthalidone; Double-Blind Method; D

2002
The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure.
    Heart (British Cardiac Society), 2003, Volume: 89, Issue:10

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Blood Pressure; Cardiac Output, Low; Chro

2003

Other Studies

2 other studies available for doxazosin and Cardiac Output, Low

ArticleYear
Summaries for patients. Blood pressure drugs and heart failure.
    Annals of internal medicine, 2002, Sep-03, Volume: 137, Issue:5 Part 1

    Topics: Antihypertensive Agents; Blood Pressure; Cardiac Output, Low; Chlorthalidone; Double-Blind Method; D

2002
Vasodilator therapy for acute heart failure: haemodynamic comparison of hydralazine/isosorbide, alpha-adrenoceptor blockade, and angiotensin-converting enzyme inhibition.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Cardiac Output,

1992