Page last updated: 2024-10-26

doxazosin and Cardiac Failure

doxazosin has been researched along with Cardiac Failure in 40 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Research Excerpts

ExcerptRelevanceReference
"This study was designed to evaluate the effect of carvedilol on nitrate tolerance in patients with chronic heart failure."9.08Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure. ( Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H, 1998)
"In this study we evaluated the effects of once-daily administration of oral doxazosin in patients with chronic congestive heart failure (CHF)."9.07Doxazosin for the treatment of chronic congestive heart failure: results of a randomized double-blind and placebo-controlled study. ( Chakko, S; DiBianco, R; Emmanuel, G; Marlon, A; Parker, JO; Singh, JB; Tanser, PH, 1991)
"Doxazosin treatment has been discouraged in hypertensive patients in order to prevent heart failure (HF) development."7.75Safety and efficacy of doxazosin as an "add-on" antihypertensive therapy in mild to moderate heart failure patients. ( Arioli, F; Cuko, A; Fragasso, G; Gardini, C; Margonato, A; Palloshi, A; Roccaforte, R; Salerno, A; Spoladore, R, 2009)
"Lower heart failure (HF) rates in individuals taking chlorthalidone vs amlodipine, lisinopril, or doxazosin were unanticipated in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)."5.14Heart failure in ALLHAT: did blood pressure medication at study entry influence outcome? ( Barzilay, J; Cutler, JA; Dart, RA; Davis, BR; Graumlich, JF; Grimm, RH; Margolis, KL; Murden, RA; Piller, LB; Randall, OS, 2009)
" The double-blind, active-controlled component of ALLHAT was designed to determine whether the rate of the primary outcome-a composite of fatal coronary heart disease and nonfatal myocardial infarction-differs between diuretic (chlorthalidone) treatment and each of three other classes of antihypertensive drugs: a calcium antagonist (amlodipine), an angiotensin-converting enzyme inhibitor (lisinopril), and an alpha-adrenergic blocker (doxazosin) in high-risk hypertensive persons ages 55 years and older."5.09Operational aspects of terminating the doxazosin arm of The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ( Bettencourt, J; Davis, BR; Ford, CE; Furberg, CD; Geraci, TS; Kimmel, B; Kingry, C; Lusk, C; Nwachuku, C; Parks, H; Piller, LB; Pressel, SL; Simpson, LM; Wright, JT, 2001)
"This study was designed to evaluate the effect of carvedilol on nitrate tolerance in patients with chronic heart failure."5.08Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure. ( Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H, 1998)
"In this study we evaluated the effects of once-daily administration of oral doxazosin in patients with chronic congestive heart failure (CHF)."5.07Doxazosin for the treatment of chronic congestive heart failure: results of a randomized double-blind and placebo-controlled study. ( Chakko, S; DiBianco, R; Emmanuel, G; Marlon, A; Parker, JO; Singh, JB; Tanser, PH, 1991)
"Doxazosin treatment has been discouraged in hypertensive patients in order to prevent heart failure (HF) development."3.75Safety and efficacy of doxazosin as an "add-on" antihypertensive therapy in mild to moderate heart failure patients. ( Arioli, F; Cuko, A; Fragasso, G; Gardini, C; Margonato, A; Palloshi, A; Roccaforte, R; Salerno, A; Spoladore, R, 2009)
"ALLHAT, a randomized, double-blind, active-controlled hypertension treatment trial in 42,418 patients, reported that a thiazide-type diuretic (chlorthalidone) was superior to a calcium channel blocker (amlodipine), an angiotensin-converting enzyme inhibitor (lisinopril), and an alpha1-blocker (doxazosin) in preventing the new onset of heart failure (HF)."3.74The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis. ( Black, HR; Cushman, WC; Davis, BR; Einhorn, PT; Levy, D; Massie, BM; Nwachuku, CE; Piller, LB; Simpson, LM, 2007)
" To assess whether these differential structural effects do translate into different effects on LV function and on heart failure mortality, Bd or sham Bd 8-week-old rats were randomized to vehicle treatment (Vh), chemical sympathectomy ([Sx] 6-hydroxydopamine, 150 mg/kg IP twice a week), beta-adrenoceptor blockade (propranolol [Pro], 40 mg/kg per day PO), or alpha-adrenoceptor blockade (doxazosin [Dox], 5 mg/kg per day PO)."3.73Survival benefits of different antiadrenergic interventions in pressure overload left ventricular hypertrophy/failure. ( Busca, G; Cesana, F; Clari, F; Ferrari, AU; Ferrero, I; Gatti, C; Janetti, MB; Mancia, G; Palladini, G; Perlini, S; Tozzi, R; Vezzoli, M, 2006)
"Background Hypertension is a known risk factor for heart failure ( HF ), possibly via the mechanism of cardiac remodeling and left ventricular hypertrophy ( LVH )."2.90Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. ( Davis, BR; Johnson, K; Oparil, S; Tereshchenko, LG, 2019)
"Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases."2.72Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. ( Colon, P; Crow, R; Cutler, JA; Davis, BR; Dunn, K; Ellsworth, A; Franklin, S; Furberg, C; Goff, D; Golden, J; Leenen, F; Mohiuddin, S; Papademetriou, V; Piller, LB; Proschan, M, 2006)
"The doxazosin arm was terminated early, when the trial's safety and monitoring board noted a twofold higher incidence of congestive heart failure in patients receiving doxazosin than in those receiving chlorthalidone (8."1.31Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial. ( Vidt, DG, 2000)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (7.50)18.2507
2000's34 (85.00)29.6817
2010's3 (7.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Drzayich Antol, D1
Waldman Casebeer, A1
Khoury, R1
Michael, T1
Renda, A1
Hopson, S1
Parikh, A1
Stein, A1
Costantino, M1
Stemkowski, S1
Bunce, M1
Nevo, N1
Abu-Abeid, S1
Hazzan, D1
Lahat, G1
Nachmani, I1
Eldar, SM1
Zhang, L1
Xia, X1
Zhong, Y1
Xie, D1
Liu, S1
Wang, X1
Tu, J1
Faconti, L1
Mills, CE1
Govoni, V1
Gu, H1
Morant, S1
Jiang, B1
Cruickshank, JK1
Webb, AJ1
Lin, J1
Wu, YJ1
Liang, X1
Ji, M1
Ying, HM1
Wang, XY1
Sun, X1
Shao, CH1
Zhan, LX1
Zhang, Y1
Czamara, K1
Karnas, E1
Majka, Z1
Wojcik, T1
Zuba-Surma, EK1
Baranska, M1
Kaczor, A1
Liu, X1
Zhou, F1
Yang, Y1
Wang, W1
Niu, L1
Zuo, D1
Li, X1
Hua, H1
Zhang, B1
Kou, Y1
Guo, J1
Kong, F1
Pan, W1
Gao, D1
Meves, JM1
Sun, H1
Xue, M1
Zhang, Q1
Wang, Y1
Tang, R1
Iso, T1
Haruyama, H1
Sunaga, H1
Matsui, H1
Matsui, M1
Tanaka, R1
Umbarawan, Y1
Syamsunarno, MRAA1
Putri, M1
Yamaguchi, A1
Hanaoka, H1
Negishi, K1
Yokoyama, T1
Kurabayashi, M1
Palomo-Briones, R1
Esquivel-González, S1
Aizpuru, A1
Gómez-Hernández, N1
Casas-Flores, S1
Barba de la Rosa, AP1
Arriaga, S1
Peterson, ME1
Carothers, MA1
Gamble, DA1
Rishniw, M1
Johnson, K1
Oparil, S1
Davis, BR6
Tereshchenko, LG1
Kostis, JB1
Simpson, LM3
Black, HR2
Cushman, WC2
Einhorn, PT2
Farber, MA1
Ford, CE2
Levy, D2
Massie, BM2
Nawaz, S1
Barrios, V1
Escobar, C1
Tomás, JP1
Calderon, A1
Echarri, R1
Spoladore, R1
Roccaforte, R1
Fragasso, G1
Gardini, C1
Palloshi, A1
Cuko, A1
Arioli, F1
Salerno, A1
Margonato, A1
Grimm, RH1
Piller, LB4
Cutler, JA2
Margolis, KL1
Barzilay, J1
Dart, RA1
Graumlich, JF1
Murden, RA1
Randall, OS1
Chapman, N1
Chen, CY1
Fujita, T1
Hobbs, FD1
Kim, SJ1
Staessen, JA1
Tanomsup, S1
Wang, JG1
Williams, B1
Paran, E1
Düsing, R1
Lohm, L1
Lindh, E1
Frösing, R1
Järhult, B2
Lindahl, SO2
Furberg, C2
Gustafsson, LL1
Cervera Casino, P1
Ruiz García, V1
Gervas Camacho, J1
Kieback, AG1
Rödiger, O1
Jaenecke, H1
Grohmann, A1
Wernecke, KD1
Baumann, G1
Felix, SB1
Dunn, K1
Franklin, S1
Goff, D1
Leenen, F1
Mohiuddin, S1
Papademetriou, V1
Proschan, M1
Ellsworth, A1
Golden, J1
Colon, P1
Crow, R1
Yusuf, S1
Perlini, S1
Ferrero, I1
Palladini, G1
Tozzi, R1
Gatti, C1
Vezzoli, M1
Cesana, F1
Janetti, MB1
Clari, F1
Busca, G1
Mancia, G1
Ferrari, AU1
Nwachuku, CE1
Kukin, ML1
Kalman, J1
Mannino, M1
Freudenberger, R1
Buchholz, C1
Ocampo, O1
Watanabe, H1
Kakihana, M1
Ohtsuka, S1
Sugishita, Y1
SoRelle, R1
Messerli, FH3
Ball, SG1
Thackray, S1
Witte, K1
Clark, AL1
Cleland, JG1
Vidt, DG1
Grossman, E1
Hansson, L1
Feldman, RD1
Campbell, N1
Larochelle, P1
Osnes, JB1
Aass, H1
Andersen, GO1
Skomedal, T1
Pressel, SL1
Wright, JT1
Geraci, TS1
Kingry, C1
Bettencourt, J1
Kimmel, B1
Lusk, C1
Parks, H1
Nwachuku, C1
Furberg, CD1
McLellan, F1
Faulhaber, HD1
Simon, HB1
Kjeldsen, SE1
DiBianco, R1
Parker, JO1
Chakko, S1
Tanser, PH1
Emmanuel, G1
Singh, JB1
Marlon, A1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000542]Phase 30 participants Interventional1993-08-31Completed
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055]Phase 475 participants (Anticipated)Interventional2023-08-25Recruiting
A Randomized Controlled Trial of Influenza Vaccine to Prevent Adverse Vascular Events: A Pilot Study[NCT01945268]Phase 4107 participants (Actual)Interventional2015-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for doxazosin and Cardiac Failure

ArticleYear
Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension?
    Journal of hypertension, 2010, Volume: 28, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Clinical Trials as

2010
Doxazosin and congestive heart failure.
    Journal of the American College of Cardiology, 2001, Nov-01, Volume: 38, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adverse Drug Reaction Reporting Systems; Angiotensin-Converting Enzyme

2001

Trials

13 trials available for doxazosin and Cardiac Failure

ArticleYear
    Journal of patient-reported outcomes, 2018, Volume: 2

    Topics: Adult; Aged; Animals; Astrocytes; Bariatric Surgery; Beta vulgaris; Bioreactors; Biotechnology; Bloo

2018
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
    Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8

    Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography

2019
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
    Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8

    Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography

2019
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
    Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8

    Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography

2019
Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
    Journal of the American Heart Association, 2019, 04-16, Volume: 8, Issue:8

    Topics: Aged; Amlodipine; Antihypertensive Agents; Causality; Chlorthalidone; Doxazosin; Electrocardiography

2019
Heart failure with preserved and reduced left ventricular ejection fraction in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.
    Circulation, 2008, Nov-25, Volume: 118, Issue:22

    Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Antihypertensive Agents; Coronary Disease; Double-Bl

2008
Heart failure in ALLHAT: did blood pressure medication at study entry influence outcome?
    Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:9

    Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Confidence Intervals; Double-Blind Meth

2009
Hemodynamic effects of alpha1-adrenoceptor antagonist, doxazosin, in patients with chronic congestive heart failure.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:4

    Topics: Adrenergic alpha-Antagonists; Aged; Chronic Disease; Double-Blind Method; Doxazosin; Electrocardiogr

2005
Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
    Circulation, 2006, May-09, Volume: 113, Issue:18

    Topics: Adrenergic beta-Antagonists; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihyperte

2006
Combined alpha-beta blockade (doxazosin plus metoprolol) compared with beta blockade alone in chronic congestive heart failure.
    The American journal of cardiology, 1996, Mar-01, Volume: 77, Issue:7

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Chronic Disease; Doxazosin;

1996
Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure.
    Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5

    Topics: Adrenergic Antagonists; Aged; Blood Flow Velocity; Blood Platelets; Blood Pressure; Carbazoles; Carv

1998
National Heart, Lung, and Blood Institute halts part of antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
    Circulation, 2000, Mar-28, Volume: 101, Issue:12

    Topics: Adrenergic alpha-Antagonists; Anticholesteremic Agents; Chlorthalidone; Diuretics; Doxazosin; Female

2000
Implications of discontinuation of doxazosin arm of ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
    Lancet (London, England), 2000, Mar-11, Volume: 355, Issue:9207

    Topics: Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Antihypertensive Agents; Chlortha

2000
Clinical trials update: OPTIME-CHF, PRAISE-2, ALL-HAT.
    European journal of heart failure, 2000, Volume: 2, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amlodipine; Angiotensin-Converting Enzyme

2000
Operational aspects of terminating the doxazosin arm of The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
    Controlled clinical trials, 2001, Volume: 22, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Antihypertensive Agents; Cause of Death; Coronary Disease;

2001
Doxazosin for the treatment of chronic congestive heart failure: results of a randomized double-blind and placebo-controlled study.
    American heart journal, 1991, Volume: 121, Issue:1 Pt 2

    Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Doxazosin; Exercise; Female; Heart Failure; Hemod

1991

Other Studies

25 other studies available for doxazosin and Cardiac Failure

ArticleYear
Doxazosin and heart failure: to be or not to be.
    Journal of hypertension, 2009, Volume: 27, Issue:2

    Topics: Antihypertensive Agents; Doxazosin; Heart Failure; Humans; Hypertension; Hypertrophy, Left Ventricul

2009
Safety and efficacy of doxazosin as an "add-on" antihypertensive therapy in mild to moderate heart failure patients.
    Acta cardiologica, 2009, Volume: 64, Issue:4

    Topics: Aged; Antihypertensive Agents; Doxazosin; Female; Heart Failure; Hospitalization; Humans; Hypertensi

2009
Doxazosin and ALLHAT trial: a response.
    American journal of hypertension, 2002, Volume: 15, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Clinical Trials as Topic; Doxazos

2002
[The new (old) knowledge in primary prevention of stroke. It depends on lowering of blood pressure].
    MMW Fortschritte der Medizin, 2003, Volume: 145 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2003
[Alfadil and heart failure--clinical conclusions do exist!].
    Lakartidningen, 2003, Dec-04, Volume: 100, Issue:49

    Topics: Anticholesteremic Agents; Antihypertensive Agents; Doxazosin; Drug Information Services; Heart Failu

2003
[Doxazosin and heart failure: truthful information--for the sake of patients].
    Lakartidningen, 2003, Nov-27, Volume: 100, Issue:48

    Topics: Antihypertensive Agents; Doxazosin; Drug Information Services; Heart Failure; Humans

2003
[Doxazosin and heart failure: a clinical conclusion is wanted].
    Lakartidningen, 2003, Dec-18, Volume: 100, Issue:51-52

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Doxazosin; Heart Failure; Humans; Hypertensio

2003
[Alfadil--positive documentation when it comes to safety is missing].
    Lakartidningen, 2003, Dec-18, Volume: 100, Issue:51-52

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Documentation; Doxazosin; Drug Information Se

2003
[Choice of antihypertensive agent--insignificant role of doxazosin (Alfadil). How are evidence-based recommendations implemented?].
    Lakartidningen, 2004, Jan-15, Volume: 101, Issue:3

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Contraindications; Doxazosin; Evidence-Based

2004
[Antihypertensive therapy and congestive heart failure].
    Medicina clinica, 2005, Apr-09, Volume: 124, Issue:13

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Doxazosin; Drug Utilization; Heart Failure; H

2005
Preventing vascular events due to elevated blood pressure.
    Circulation, 2006, May-09, Volume: 113, Issue:18

    Topics: Antihypertensive Agents; Cardiovascular Diseases; Chlorthalidone; Comorbidity; Doxazosin; Drug Thera

2006
Survival benefits of different antiadrenergic interventions in pressure overload left ventricular hypertrophy/failure.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 48, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aorta, Abdominal; Blood Pressure

2006
The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis.
    American heart journal, 2007, Volume: 153, Issue:1

    Topics: Adrenergic alpha-Antagonists; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2007
Discontinuation of doxazosin arm of ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack.
    Lancet (London, England), 2000, Apr-29, Volume: 355, Issue:9214

    Topics: Antihypertensive Agents; Coronary Disease; Doxazosin; Heart Failure; Humans

2000
Diuretics vs. alpha blockers.
    Harvard heart letter : from Harvard Medical School, 2000, Volume: 10, Issue:10

    Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Ca

2000
Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial.
    Cleveland Clinic journal of medicine, 2000, Volume: 67, Issue:6

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Chlorthalidone; Doxazosin; Female; Heart Fail

2000
Doxazosin arm of the ALLHAT study discontinued: how equal are antihypertensive drugs? Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial.
    Current hypertension reports, 2000, Volume: 2, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors;

2000
First-line antihypertensive therapy.
    Lancet (London, England), 2000, Aug-05, Volume: 356, Issue:9228

    Topics: Antihypertensive Agents; Doxazosin; Heart Failure; Humans; Myocardial Infarction; Randomized Control

2000
First-line antihypertensive therapy. Task Force for the Development of the 1999 Canadian Recommendations for the Management of Hypertension.
    Lancet (London, England), 2000, Aug-05, Volume: 356, Issue:9228

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Doxazosin; Heart Failure; Humans; Randomized

2000
First-line antihypertensive therapy.
    Lancet (London, England), 2000, Aug-05, Volume: 356, Issue:9228

    Topics: Antihypertensive Agents; Chlorthalidone; Doxazosin; Heart Failure; Humans; Myocardium; Randomized Co

2000
US FDA weighs options for warning on antihypertensive drug.
    Lancet (London, England), 2001, Jun-02, Volume: 357, Issue:9270

    Topics: Antihypertensive Agents; Doxazosin; Drug Labeling; Heart Failure; Humans; United States; United Stat

2001
[Alpha-blockers in therapy of arterial hypertension. No longer the drug of first choice].
    MMW Fortschritte der Medizin, 2001, May-31, Volume: 143, Issue:22

    Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Cause of Death; Chlorthalidone; Doxazos

2001
On call. I'm a 76-year-old man with an enlarged prostate. I've been taking Cardura and it's helped a lot, but my doctor stopped it because he said a study found the drug could cause heart failure. Now I'm getting up three or four times a night again. Is C
    Harvard men's health watch, 2001, Volume: 5, Issue:12

    Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Doxazosin; Heart Failure; Humans; Hyper

2001
Heart lines. Cardura update.
    Harvard heart letter : from Harvard Medical School, 2001, Volume: 12, Issue:1

    Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Diuretics; Doxazosin; Heart Failure; Humans;

2001
Warning for antihypertensive drug?
    Lancet (London, England), 2001, Oct-06, Volume: 358, Issue:9288

    Topics: Antihypertensive Agents; Clinical Trials as Topic; Doxazosin; Drug Labeling; Heart Failure; Humans;

2001