doxazosin has been researched along with Arteriosclerosis in 9 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension treatment with doxazosin or HCTZ resulted in a comparable change in arterial IMT after three years, in spite of differences in effect on plasma lipids." | 5.10 | Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands. ( Birkenhägeri, JC; de Groot, E; de Heide, LH; de Ridder, MA; Hoogerbrugge, N; Jansen, H; Stijnen, T, 2002) |
| " With the monotherapy of essential hypertension concurrent with hypercholesterolemia with the alpha 1-adrenoblocker Doxazosin, in addition to the agent's high antihypertensive effects, the authors noted its favourable action on lipid spectral parameters and platelet functional activity." | 3.69 | [Hypertension, diabetes mellitus, atherosclerosis: clinical manifestations of metabolic syndrome X. Prospects of pharmacological treatment]. ( Ivleva, AIa; Kobalava, ZhD; Moiseev, VS, 1995) |
| "Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1." | 2.70 | Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. ( Higaki, J; Jinno, T; Katsuya, T; Komai, N; Matsumoto, K; Moriguchi, A; Ogihara, T; Ohishi, M; Rakugi, H; Yanagitani, Y, 2002) |
| "Doxazosin was more effective in decreasing contractions when it was combined with sildenafil or the nitric oxide (NO) precursor L-arginine." | 1.32 | Chronic ischemia increases prostatic smooth muscle contraction in the rabbit. ( Azadzoi, KM; Babayan, RK; Kozlowski, R; Siroky, MB, 2003) |
| "Doxazosin was administered to rabbits fed diets enriched in cholesterol and peanut oil for 7." | 1.29 | Effects of doxazosin on atherosclerosis in cholesterol-fed rabbits. ( Chichester, CO; Krupp, MN; Reynolds, JA; Swindell, AC; Twomey, TM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoogerbrugge, N | 1 |
| de Groot, E | 1 |
| de Heide, LH | 1 |
| de Ridder, MA | 1 |
| Birkenhägeri, JC | 1 |
| Stijnen, T | 1 |
| Jansen, H | 1 |
| Azadzoi, KM | 1 |
| Babayan, RK | 1 |
| Kozlowski, R | 1 |
| Siroky, MB | 1 |
| Wilson, TA | 1 |
| Foxall, TL | 2 |
| Nicolosi, RJ | 4 |
| Moiseev, VS | 1 |
| Ivleva, AIa | 1 |
| Kobalava, ZhD | 1 |
| Swindell, AC | 1 |
| Krupp, MN | 1 |
| Twomey, TM | 1 |
| Reynolds, JA | 1 |
| Chichester, CO | 1 |
| Komai, N | 1 |
| Ohishi, M | 1 |
| Moriguchi, A | 1 |
| Yanagitani, Y | 1 |
| Jinno, T | 1 |
| Matsumoto, K | 1 |
| Katsuya, T | 1 |
| Rakugi, H | 1 |
| Higaki, J | 1 |
| Ogihara, T | 1 |
| Shwaery, GT | 1 |
| Stucchi, AF | 1 |
| Wong, SS | 1 |
| Kowala, MC | 2 |
| Nunnari, JJ | 1 |
| Durham, SK | 1 |
2 trials available for doxazosin and Arteriosclerosis
| Article | Year |
|---|---|
Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands.
Topics: Aged; Antihypertensive Agents; Arteriosclerosis; Carotid Arteries; Disease Progression; Diuretics; D | 2002 |
Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation.
Topics: Adrenergic alpha-Antagonists; Aorta; Arteriosclerosis; Doxazosin; Elasticity; Endothelium, Vascular; | 2002 |
7 other studies available for doxazosin and Arteriosclerosis
| Article | Year |
|---|---|
Chronic ischemia increases prostatic smooth muscle contraction in the rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Arginine; Arteriosclerosis; Blood Flow Velocity; Cyclic GMP; | 2003 |
Doxazosin, an alpha-1 antagonist, prevents further progression of the advanced atherosclerotic lesion in hypercholesterolemic hamsters.
Topics: Adrenergic alpha-Antagonists; Animals; Anticholesteremic Agents; Aorta; Arteriosclerosis; Cholestero | 2003 |
[Hypertension, diabetes mellitus, atherosclerosis: clinical manifestations of metabolic syndrome X. Prospects of pharmacological treatment].
Topics: Anticholesteremic Agents; Arteriosclerosis; Diabetes Mellitus; Diabetes Mellitus, Type 2; Doxazosin; | 1995 |
Effects of doxazosin on atherosclerosis in cholesterol-fed rabbits.
Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Collagen; Doxazosin; Elastin; L | 1993 |
Dose-related effects of doxazosin on plasma lipids and aortic fatty streak formation in the hypercholesterolemic hamster model.
Topics: Adrenergic alpha-Antagonists; Animals; Aortic Diseases; Arteriosclerosis; Cricetinae; Dose-Response | 1992 |
Doxazosin and cholestyramine similarly decrease fatty streak formation in the aortic arch of hyperlipidemic hamsters.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteriosclerosis; Blood Pressure; Cholestero | 1991 |
Effect of doxazosin on plasma lipids and atherogenesis: a preliminary report.
Topics: Adrenergic alpha-Antagonists; Animals; Arteriosclerosis; Blood Pressure; Cholesterol; Cholesterol, H | 1989 |