doxazosin has been researched along with Alcoholism in 5 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) are two of the most common mental health disorders affecting civilians as well as military populations." | 2.87 | Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans. ( Augur, I; Back, SE; Brady, KT; Flanagan, JC; Hancock, AK; Henschel, A; Jones, JL; Joseph, JE; Keane, TM; Litz, BT; Mintz, J; Peterson, AL; Roache, JD; Shirley, DW; Wachen, JS; Young-McCaughan, S, 2018) |
| "The comorbidity between alcohol use disorder and post-traumatic stress disorder represents a serious health care burden with few effective treatment options." | 1.56 | Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress. ( Becker, HC; Carper, BA; Lopez, MF; Nolen, TL; Reasons, SE; Williams, RL, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez, MF | 1 |
| Reasons, SE | 1 |
| Carper, BA | 1 |
| Nolen, TL | 1 |
| Williams, RL | 1 |
| Becker, HC | 1 |
| Haass-Koffler, CL | 2 |
| Goodyear, K | 1 |
| Zywiak, WH | 2 |
| Magill, M | 1 |
| Eltinge, SE | 1 |
| Wallace, PM | 1 |
| Long, VM | 1 |
| Jayaram-Lindström, N | 1 |
| Swift, RM | 2 |
| Kenna, GA | 3 |
| Leggio, L | 3 |
| Back, SE | 1 |
| Flanagan, JC | 1 |
| Jones, JL | 1 |
| Augur, I | 1 |
| Peterson, AL | 1 |
| Young-McCaughan, S | 1 |
| Shirley, DW | 1 |
| Henschel, A | 1 |
| Joseph, JE | 1 |
| Litz, BT | 1 |
| Hancock, AK | 1 |
| Roache, JD | 1 |
| Mintz, J | 1 |
| Wachen, JS | 1 |
| Keane, TM | 1 |
| Brady, KT | 1 |
| Edwards, SM | 1 |
| Brickley, MB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Focus on Alpha-1 Blockade as a Novel Pharmacological Treatment for AUD[NCT04135846] | Phase 2 | 184 participants (Anticipated) | Interventional | 2019-12-19 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for doxazosin and Alcoholism
| Article | Year |
|---|---|
Higher pretreatment blood pressure is associated with greater alcohol drinking reduction in alcohol-dependent individuals treated with doxazosin.
Topics: Adult; Alcohol Drinking; Alcoholism; Blood Pressure; Double-Blind Method; Doxazosin; Female; Humans; | 2017 |
Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans.
Topics: Adrenergic alpha-1 Receptor Antagonists; Alcoholism; Brain; Double-Blind Method; Doxazosin; Function | 2018 |
Role of the α1 blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Alcoholism; Double-Blind Method; Doxazosin; Female; | 2016 |
2 other studies available for doxazosin and Alcoholism
| Article | Year |
|---|---|
Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
Topics: Alcohol Drinking; Alcoholism; Animals; Doxazosin; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; S | 2020 |
Commentary: Doxazosin for alcoholism.
Topics: Adrenergic alpha-1 Receptor Antagonists; Alcohol Drinking; Alcoholism; Animals; Disease Models, Anim | 2013 |