Page last updated: 2024-10-26

doxazosin and Alcoholism

doxazosin has been researched along with Alcoholism in 5 studies

Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.

Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Research Excerpts

ExcerptRelevanceReference
"Posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) are two of the most common mental health disorders affecting civilians as well as military populations."2.87Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans. ( Augur, I; Back, SE; Brady, KT; Flanagan, JC; Hancock, AK; Henschel, A; Jones, JL; Joseph, JE; Keane, TM; Litz, BT; Mintz, J; Peterson, AL; Roache, JD; Shirley, DW; Wachen, JS; Young-McCaughan, S, 2018)
"The comorbidity between alcohol use disorder and post-traumatic stress disorder represents a serious health care burden with few effective treatment options."1.56Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress. ( Becker, HC; Carper, BA; Lopez, MF; Nolen, TL; Reasons, SE; Williams, RL, 2020)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Lopez, MF1
Reasons, SE1
Carper, BA1
Nolen, TL1
Williams, RL1
Becker, HC1
Haass-Koffler, CL2
Goodyear, K1
Zywiak, WH2
Magill, M1
Eltinge, SE1
Wallace, PM1
Long, VM1
Jayaram-Lindström, N1
Swift, RM2
Kenna, GA3
Leggio, L3
Back, SE1
Flanagan, JC1
Jones, JL1
Augur, I1
Peterson, AL1
Young-McCaughan, S1
Shirley, DW1
Henschel, A1
Joseph, JE1
Litz, BT1
Hancock, AK1
Roache, JD1
Mintz, J1
Wachen, JS1
Keane, TM1
Brady, KT1
Edwards, SM1
Brickley, MB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Focus on Alpha-1 Blockade as a Novel Pharmacological Treatment for AUD[NCT04135846]Phase 2184 participants (Anticipated)Interventional2019-12-19Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for doxazosin and Alcoholism

ArticleYear
Higher pretreatment blood pressure is associated with greater alcohol drinking reduction in alcohol-dependent individuals treated with doxazosin.
    Drug and alcohol dependence, 2017, 08-01, Volume: 177

    Topics: Adult; Alcohol Drinking; Alcoholism; Blood Pressure; Double-Blind Method; Doxazosin; Female; Humans;

2017
Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans.
    Contemporary clinical trials, 2018, Volume: 73

    Topics: Adrenergic alpha-1 Receptor Antagonists; Alcoholism; Brain; Double-Blind Method; Doxazosin; Function

2018
Role of the α1 blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial.
    Addiction biology, 2016, Volume: 21, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Alcoholism; Double-Blind Method; Doxazosin; Female;

2016

Other Studies

2 other studies available for doxazosin and Alcoholism

ArticleYear
Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
    Alcohol (Fayetteville, N.Y.), 2020, Volume: 89

    Topics: Alcohol Drinking; Alcoholism; Animals; Doxazosin; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; S

2020
Commentary: Doxazosin for alcoholism.
    Alcoholism, clinical and experimental research, 2013, Volume: 37, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Alcohol Drinking; Alcoholism; Animals; Disease Models, Anim

2013